scholarly journals Synthetic Studies and Antibacterial Activity of Nucleobases and their N- and S-Glucosidesfrom 2-Amino Benzoic Acid and its Benzamido Derivatives

2016 ◽  
Vol 32 (5) ◽  
pp. 2567-2576 ◽  
Author(s):  
Samia Benhammadi ◽  
Salimairaten Salimairaten ◽  
Adil Othman
Keyword(s):  
Antibacterial Activity ◽  
Benzoic Acid ◽  
Synthetic Studies ◽  
Amino Benzoic Acid

scholarly journals Synthesis and Anti-inflammatory Activity of Some Novel 3-(6-Substituted-1, 3-benzothiazole-2-yl)-2-[{(4-substituted phenyl) amino} methyl] quinazolines-4 (3H)-ones

2009 ◽  
Vol 6 (4) ◽  
pp. 1055-1062 ◽  
Author(s):  
Manish Srivastav ◽  
MD. Salahuddin ◽  
S. M. Shantakumar
Keyword(s):  
Antibacterial Activity ◽  
Benzoic Acid ◽  
Spectral Data ◽  
Elemental Analysis ◽  
Inflammatory Activity ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
Anti Inflammatory ◽  
Substituted 1 ◽  
Amino Benzoic Acid

A series of novel 3-(6-substituted-1, 3-benzothiazole-2-yl)-2-[{(4-substituted phenyl) amino} methyl] quinazolines-4(3H)-ones were synthesized by treating 2-(chloromethyl)-3-(6-substituted-1, 3-benzothiazole-2-yl) quinazoline-4-(3H)-one (IIa-d) with various substituted amine. The compounds (IIa-d) prepared by treating 2-[(chloroacetyl) amino] benzoic acid with different 2-amino-6-substituted benzothiazole. Elemental analysis, IR,1HNMR and mass spectral data confirmed the structure of the newly synthesized compounds. Synthesized quinazolines-4-one derivative were investigated for their anti-inflammatory and antibacterial activity.

scholarly journals Synthesis and antibacterial activity of some Schiff bases derived from 4-aminobenzoic acid

2005 ◽  
Vol 70 (10) ◽  
pp. 1155-1162 ◽  
Author(s):  
Jigna Parekh ◽  
Pranav Inamdhar ◽  
Rathish Nair ◽  
Shipra Baluja ◽  
Sumitra Chanda
Keyword(s):  
Molecular Structure ◽  
Antibacterial Activity ◽  
Benzoic Acid ◽  
Schiff Bases ◽  
Bacterial Strain ◽  
Antibacterial Agents ◽  
Aminobenzoic Acid ◽  
Bacterial Strains ◽  
E Coli ◽  
Amino Benzoic Acid

The following Schiff bases have been synthesized: (1) 4-(2-chlorobenzylidene)amino benzoic acid JP1, (2) 4 (furan-2-ylmethylene)amino benzoic acid JP2, (3) 4-[(3-phenylallylidene)amino]benzoic acid JP3, (4) 4 (2-hydroxybenzylidene)amino benzoic acid JP4, (5) 4 (4-hydroxy-3-methoxybenzylidene)amino benzoic acid JP5 and (6) 4 (3-nitrobenzylidene)amino benzoic acid JP6. They were screened as potential antibacterial agents against a number of medically important bacterial strains. The antibacterial activity was studied against A. faecalis ATCC 8750, E. aerogenes ATCC 13048, E. coli ATCC 25922, K. pneumoniae NCIM 2719 S. aureus ATCC 25923, P. vulgaris NCIM 8313, P. aeruginosa ATCC 27853 and S. typhimurium ATCC 23564. The antibacterial activity was evaluated using the Agar Ditch method. The solvents used were 1,4-dioxane and dimethyl sulfoxide. Different effects of the compounds were found in the bacterial strains in vestigated and the solvents used, suggesting, once again, that the antibacterial activity is dependent on the molecular structure of the compound, the solvent used and the bacterial strain under consideration. In the present work, 1,4-dioxane proved to be a good solvent in inhibiting the above stated bacterial strains.

scholarly journals One-pot synthesis of N-benzyl-2-aminobenzoic acid, via ring opening of isatoic anhydride derivative, and its antibacterial screening

2021 ◽  
Vol 18 (3) ◽  
pp. 192-195
Author(s):  
Emmanuel E. Odion ◽  
Gbemisola Ajibosin ◽  
Cyril O. Usifoh
Keyword(s):  
Antibacterial Activity ◽  
Benzoic Acid ◽  
Ring Opening ◽  
Aryl Halide ◽  
Benzyl Bromide ◽  
Yellow Crystal ◽  
Isatoic Anhydride ◽  
One Pot ◽  
Antibacterial Screening ◽  
Amino Benzoic Acid

2-(N-Benzyl) amino benzoic acid is a bifunctional molecule that could be produced from the reaction between isatoic anhydride and aryl halide. Analogues and derivatives of isatoic anhydride have wide application in pharmaceuticalsincluding antibacterial activity. The aim of this study is to synthesize, characterize and screen N-benzyl isatoic anhydride and 2-(N-benzyl) amino benzoic acid for antibacterial activity. The reaction of isatoic anhydride and benzyl bromide in the presence of potassium carbonate in DMSO at room temperature yielded N-benzyl isatoic anhydride, which under hydrolysis yielded 2-(N-benzyl) amino benzoic acid in which the anhydride ring is opened up. This compound was screened against Gram positive and negative bacteria. Moderate yield of 2-(N-benzyl) amino benzoic acid, a yellow crystal (melting point of 160-162oC, percentage yield 65 %, Rf 0.19) formed by ring opening of N-benzyl isatoic anhydride. The compound showed no antibacterial activity against Escherichia coli, Staphylococcus aureus, Pseudomonas pyocyanea, Salmonella typhimurium, Klebsiella aeruginosa and Bacillus subtilis. 2-(N-benzyl)amino benzoic was synthesized, characterized and showed no activity against bacteria.

Formation of β-hairpins in l-Pro-Gly containing peptides facilitated by 3-amino benzoic acid

2003 ◽  
Vol 44 (39) ◽  
pp. 7369-7372 ◽  
Author(s):  
M.H.V.Ramana Rao ◽  
S.Kiran Kumar ◽  
A.C. Kunwar
Keyword(s):  
Benzoic Acid ◽  
Amino Benzoic Acid

scholarly journals 4-{[(4-Methylphenyl)sulfonyl]amino}benzoic acid

2011 ◽  
Vol 67 (4) ◽  
pp. o1018-o1018 ◽  
Author(s):  
Ghulam Mustafa ◽  
Islam Ullah Khan ◽  
Muhammad Zia-ur-Rehman ◽  
Shahzad Sharif ◽  
Muhammad Nadeem Arshad
Keyword(s):  
Benzoic Acid ◽  
Amino Benzoic Acid
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