This study examines the mechanism of regulation of public-private partnership in the pharmaceutical complex of the Russian Federation as a fundamental principle of public-private partnership in general. The features of the two main national regulations that regulate public-private partnership in this area of the economy are studied, and their features are determined. The features of international regulation of public-private partnerships on a national scale, as well as in the commercial sector of the pharmaceutical complex, are studied. A number of industry standards of the pharmaceutical complex of the Russian Federation are considered, their main tasks are highlighted. The analysis of the subject composition of public-private partnerships in the pharmaceutical complex is carried out, their main differences and features are formed. Based on the results of the study of national and international standards, tools are proposed for the development and improvement of international and Russian legislation regulating public-private partnership relations in the pharmaceutical sector.