scholarly journals Malignant bone tumours of the foot

2017 ◽  
Vol 99 (7) ◽  
pp. 568-572 ◽  
Author(s):  
P Yang ◽  
S Evans ◽  
N Bali ◽  
A Ramasamy ◽  
R Evans ◽  
...  
Keyword(s):  
Bone Tumour ◽  
Bimodal Distribution ◽  
Bone Tumours ◽  
Time To Death ◽  
Left Behind ◽  
Oncological Outcomes ◽  
Malignant Bone Tumours ◽  
Foot Lesions ◽  
High Index Of Suspicion ◽  
Diagnostic Delays

Introduction Malignant osseous foot tumours are uncommon. Their oncological outcomes have been poorly documented in the literature so far. The aim of this study was to establish the incidence and to evaluate the oncological outcomes of such patients. Methods Our large orthopaedic oncology database was used to review 70 malignant osseous foot tumour patients. Results The age at diagnosis of malignant osseous foot tumours demonstrated a bimodal distribution peaking in the second and eighth decades of life. Overall, 55 primary malignant bone tumours of the foot (79%) were identified. The median duration from onset of symptoms to diagnosis was 52 weeks (interquartile range [IQR]: 17–104). Eight primary tumours (15%) underwent an accidental excision (ie intralesional excision of a malignant bone tumour where some of the tumour has been left behind, also known as a ‘whoops procedure’) prior to referral to our unit. Forty-six patients (84%) underwent surgery overall and thirteen of these developed recurrence or metastases. Seven of eight patients with a previous accidental excision underwent amputation. Fifteen osseous metastatic foot lesions were identified. The median length of foot symptoms to diagnosis was 24 weeks (IQR: 20–36 weeks). The median time to death following diagnosis of osseous foot metastases was 20.1 months (IQR: 11.3–27.8 months). Conclusions A high index of suspicion and awareness of clinical features of malignant osseous foot tumours are both essential to avoid diagnostic delays. Amputation is associated with a respectable outcome for patients who have undergone previous accidental excisions.

scholarly journals Diagnosis and staging of malignant bone tumours in children: what is due and what is new?

2021 ◽  
Vol 15 (4) ◽  
pp. 312-321 ◽  
Author(s):  
Marta Salom ◽  
Catharina Chiari ◽  
Jean Maria Gómez Alessandri ◽  
Madeleine Willegger ◽  
Reinhard Windhager ◽  
...  
Keyword(s):  
Clinical Examination ◽  
Laboratory Tests ◽  
Correct Diagnosis ◽  
Bone Tumour ◽  
Bone Tumours ◽  
Level Of Evidence ◽  
Access To Treatment ◽  
Adequate Treatment ◽  
Malignant Bone Tumours ◽  
Staging Systems

Purpose Although malignant bone tumours in children are infrequent, it is important to know how to properly diagnose and stage them, in order to establish an adequate treatment. Methods We present a review of the diagnostic workflow of malignant bone tumours in children, including history and clinical examination, imaging, laboratory tests and biopsy techniques. Moreover, the two most commonly used staging systems are reviewed. Results History, clinical examination and laboratory tests are nonspecific for diagnosing malignant bone tumours in children. Radiographs remain the mainstay for initial diagnosis, with MRI the modality of choice for local assessment and staging. Fluorine-18 labelled fluoro-deoxy-glucose-positron emission tomography scans provide a noninvasive method to assess the aggressiveness of the tumour and to rule out metastasis and is replacing the use of the bone scintigraphy. Biopsy must be always performed under the direction of the surgeon who is to perform the surgical treatment and after all diagnostic evaluation has been done. Staging systems are useful to study the extent of the tumour and its prognosis. They are expected to evolve as we better understand new molecular and genetic findings. Conclusion When a malignant bone tumour is suspected in a child, it is essential to make a correct diagnosis and referral to an experienced centre. Following an appropriate workflow for diagnosis and staging facilitates, prompt access to treatment improves outcomes. Level of Evidence Level V Expert opinion

scholarly journals Biology and technology in the surgical treatment of malignant bone tumours in children and adolescents, with a special note on the very young

2021 ◽  
Vol 15 (4) ◽  
pp. 322-330
Author(s):  
Lizz van der Heijden ◽  
Germán L. Farfalli ◽  
Inês Balacó ◽  
Cristina Alves ◽  
Marta Salom ◽  
...  
Keyword(s):  
Young Children ◽  
Young Patients ◽  
Bone Tumour ◽  
Bone Tumours ◽  
Patient Specific ◽  
Tumour Resection ◽  
Malignant Bone Tumours ◽  
Vascularized Fibula

Purpose The main challenge in reconstruction after malignant bone tumour resection in young children remains how and when growth-plates can be preserved and which options remain if impossible. Methods We describe different strategies to assure best possible long-term function for young children undergoing resection of malignant bone tumours. Results Different resources are available to treat children with malignant bones tumours: a) preoperative planning simulates scenarios for tumour resection and limb reconstruction, facilitating decision-making for surgical and reconstructive techniques in individual patients; b) allograft reconstruction offers bone-stock preservation for future needs. Most allografts are intact at long-term follow-up, but limb-length inequalities and corrective/revision surgery are common in young patients; c) free vascularized fibula can be used as stand-alone reconstruction, vascularized augmentation of structural allograft or devitalized autograft. Longitudinal growth and joint remodelling potential can be preserved, if transferred with vascularized proximal physis; d) epiphysiolysis before resection with continuous physeal distraction provides safe resection margins and maintains growth-plate and epiphysis; e) 3D printing may facilitate joint salvage by reconstruction with patient-specific instruments. Very short stems can be created for fixation in (epi-)metaphysis, preserving native joints; f) growing endoprosthesis can provide for remaining growth after resection of epi-metaphyseal tumours. At ten-year follow-up, limb survival was 89%, but multiple surgeries are often required; g) rotationplasty and amputation should be considered if limb salvage is impossible and/or would result in decreased function and quality of life. Conclusion Several biological and technological reconstruction options must be merged and used to yield best outcomes when treating young children with malignant bone tumours. Level of Evidence Level V Expert opinion

Chest wall tuberculosis in children: a mimicker of bone tumour

2021 ◽  
Vol 14 (4) ◽  
pp. e242802
Author(s):  
Muthuvel Balasubramaniyan ◽  
Sanjay Verma ◽  
Sumeet Rajendra Dhawan ◽  
Akshay Kumar saxena
Keyword(s):  
Chest Wall ◽  
Clinical Presentation ◽  
Bone Tumour ◽  
Antitubercular Therapy ◽  
Bone Tumours ◽  
Microbiological Diagnosis ◽  
Osteoarticular Tuberculosis ◽  
Malignant Bone Tumours ◽  
Atypical Clinical Presentation ◽  
Tuberculosis In Children

Osteoarticular tuberculosis of flat bones of the chest wall such as sternum, scapula and rib is extremely rare in children. Because of its atypical clinical presentation mimicking malignant bone tumours, diagnosis remains a challenge. Histological and microbiological diagnosis remains confirmatory. Antitubercular therapy is the cornerstone in management.

scholarly journals Toxoplasma gondii infection in patients with malignant and benign bone tumours

2021 ◽  
Author(s):  
M. Hajizadeh ◽  
R. Falak ◽  
M. Tavakoli ◽  
R. Hosseinzadeh ◽  
M. Alipour ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Bone Tumour ◽  
Bone Tumours ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Malignant Tumours ◽  
Cross Sectional ◽  
Blood Samples ◽  
Malignant Bone Tumours ◽  
Primary Bone

Toxoplasma gondii (T. gondii) is an intracellular parasite that infects humans and seroprevalence of its infection varies from about 10 to 80 percent in different countries with a higher prevalence in warmer and humid regions. In this study, the rate of acute and chronic toxoplasmosis in patients with benign or malignant bone tumours was investigated. Fifty-three patients who suffered from various bone tumours, as well as sixty-five healthy controls with an unknown serological profile for anti-Toxoplasma antibodies, were enrolled in this cross-sectional study. Anti-toxoplasma antibodies were detected in serum samples using enzyme-linked immunosorbent assay (ELISA) and blood samples of them were used for real-time PCR. Thirty-two (60.32%) and twenty-one (39.63%) of patients had malignant tumours and benign tumours, respectively. The results showed a higher and significant seropositivity rate of IgM antibodies in primary bone tumour patients compared to the control group and Toxoplasma DNA became positive in 18.86% of patients with primary bone tumours and 6.15% of controls. Surprisingly, the high presence of parasite DNA was detected in patients with malignant tumours. The seroprevalence of T. gondii IgM antibody and DNA positivity among the cancer patients were significantly higher than healthy individuals. Also, chronic toxoplasmosis (it was shown with IgG positive) appears to be more common in people with benign cancers than malignancies. The study showed a relatively high seroprevalence of anti-T. gondii antibodies in patients with primary bone cancer. However, the considerable rate of positive blood samples for the presence of parasite’s DNA should not be ignored. A key to the effective management of diseases in immunosuppressed individuals is prompt and accurate diagnosis of toxoplasmosis. Moreover, it seems that PCR tests may be more reliable than serological methods and it could be considered as a precise method for diagnosis of acute toxoplasmosis. 

Porous tantalum acetabular cups for reconstructions after peri-acetabular resections of primary bone tumours

2021 ◽  
pp. 112070002110015
Author(s):  
Riccardo Zucchini ◽  
Andrea Sambri ◽  
Claudio Giannini ◽  
Michele Fiore ◽  
Carlotta Calamelli ◽  
...  
Keyword(s):  
Bone Tumour ◽  
Hip Dislocation ◽  
Functional Results ◽  
Bone Tumours ◽  
Harris Hip Score ◽  
Porous Tantalum ◽  
Term Survival ◽  
Primary Bone ◽  
Primary Bone Tumours

Introduction: Periacetabular reconstruction after resection of primary bone tumour is a very demanding procedure. They are frequently associated with scarce functional results and a high rate of complications. We report a series of patients with periacetabular resections for primary bone tumours and reconstruction with a porous tantalum (PT) acetabular cup (AC). Materials and methods: 27 patients (median age 30 years) were included, being affected by primary bone tumours of the pelvis and treated with peri-acetabular resection and reconstruction with a PT AC. The diagnoses were 13 osteosarcomas, 7 chondrosarcomas and 7 Ewing sarcomas. Function was assessed with the Harris Hip Score and complications were classified according to Zeifang. Results: The median follow-up was 70 months. 1 patient required removal of the PT AC because of implant associated infection 55 months after surgery. There was 1 hip dislocation and no case of aseptic loosening. At final follow-up, the median HHS was 81 points (range 48–92). Conclusions: The used PT AC had good medium-term survival rates and good functional results. This technique is a viable reconstructive option after resections of periacetabular primary bone sarcomas.

scholarly journals Treatment of primary malignant bone tumours of the distal tibia

2005 ◽  
Vol 29 (4) ◽  
pp. 255-259 ◽  
Author(s):  
M. Laitinen ◽  
J. Hardes ◽  
H. Ahrens ◽  
C. Gebert ◽  
B. Leidinger ◽  
...  
Keyword(s):  
Distal Tibia ◽  
Bone Tumours ◽  
Malignant Bone Tumours

The course of fibrinolytic proteins in children with malignant bone tumours

1999 ◽  
Vol 158 (S3) ◽  
pp. S151-S153 ◽  
Author(s):  
U. Nowak-Göttl ◽  
N. Münchow ◽  
U. Klippel ◽  
M. Paulussen ◽  
S. Bielack ◽  
...  
Keyword(s):  
Bone Tumours ◽  
Malignant Bone Tumours ◽  
Fibrinolytic Proteins

scholarly journals Treatment of malignant bone tumours by extracorporeally irradiated autograft-prosthetic composite arthroplasty

2002 ◽  
Vol 84-B (8) ◽  
pp. 1156-1161 ◽  
Author(s):  
W. M. Chen ◽  
T. H. Chen ◽  
C. K. Huang ◽  
C. C. Chiang ◽  
W. H. Lo
Keyword(s):  
Bone Tumours ◽  
Malignant Bone Tumours

Imaging following allograft reconstruction in children with malignant bone tumours

1999 ◽  
Vol 29 (10) ◽  
pp. 785-793 ◽  
Author(s):  
D. J. Roebuck ◽  
James F. Griffith ◽  
Shekar M. Kumta ◽  
P. C. Leung ◽  
Constantine Metreweli
Keyword(s):  
Bone Tumours ◽  
Allograft Reconstruction ◽  
Malignant Bone Tumours

scholarly journals Peritoneal Tuberculosis Presenting as Chronic Ascites With Scrofula: A Case Report

2019 ◽  
Vol 13 (1) ◽  
Author(s):  
Galina Bogoslovskaya ◽  
Jose Zaldivar
Keyword(s):  
Case Report ◽  
Early Diagnosis ◽  
Extrapulmonary Tuberculosis ◽  
Young Female ◽  
Ca 125 ◽  
Test Results ◽  
Peritoneal Tuberculosis ◽  
Clinical Presentations ◽  
High Index Of Suspicion ◽  
Diagnostic Delays

Peritoneal tuberculosis (PTB) is a common type of extrapulmonary tuberculosis; however, due to variety of clinical presentations, diagnostic challenges do occur. The nonspecific features of this disease can lead to diagnostic delays and the development of complications. In addition, PTB can mimic a malignancy, especially in women who present with ascites and elevated cancer antigen (CA) 125 levels. A high index of suspicion is an important factor in an early diagnosis. Moreover, an early diagnosis and the initiation of antituberculous therapy are essential for preventing morbidity and mortality. Fortunately, most of these patients respond very well to standard antituberculous therapy.Here, we have reported the case of a young female patient who presented with chronic ascites, mild abdominal tenderness, and later, scrofula. Ultimately, she was diagnosed with PTB based on her test results. We expect that this case report will contribute to the existing literature on this subject.

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