Acute Liver Injury Caused by Intravenous Amiodarone;Myoclonus Associated with Long-term Use of Diltiazem;Involuntary Movements Associated with Cetirizine;Cocaine-Induced Ischemic Bowel;Asenapine and Severe Allergic Reactions;Dapsone-Induced Methemoglobinemia;Neurotoxic Effects Associated with Antibiotic Use

The purpose of this feature is to heighten awareness of specific adverse drug reactions (ADRs), discuss methods of prevention, and promote reporting of ADRs to the US Food and Drug Administration's (FDA's) MEDWATCH program (800-FDA-1088). If you have reported an interesting, preventable ADR to MEDWATCH, please consider sharing the account with our readers.

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Sildenafil-Induced Erythema Multiforme Acute Liver Injury Due to Febuxostat Intravenous Acetaminophen-Induced Acute Hepatotoxicity Acute Transient Myopia Induced by Zanamivir Lidocaine-Induced Hoigne Syndrome

Hospital Pharmacy ◽

10.1310/hpj5111-884 ◽

2016 ◽

Vol 51 (11) ◽

pp. 884-887

Author(s):

Michael A. Mancano

Keyword(s):

Liver Injury ◽

Adverse Drug Reactions ◽

Erythema Multiforme ◽

Acute Liver Injury ◽

Drug Reactions ◽

Transient Myopia ◽

Intravenous Acetaminophen ◽

The Us

The purpose of this feature is to heighten awareness of specific adverse drug reactions (ADRs), discuss methods of prevention, and promote reporting of ADRs to the US Food and Drug Administration's (FDA's) MedWatch program (800-FDA-1088). If you have reported an interesting, preventable ADR to MedWatch, please consider sharing the account with our readers.

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Amiodarone-Induced Acute Liver Injury

Case Reports in Gastroenterology ◽

10.1159/000506184 ◽

2020 ◽

Vol 14 (1) ◽

pp. 87-90

Author(s):

Rajesh Essrani ◽

Shehriyar Mehershahi ◽

Rajesh Kumar Essrani ◽

Shri Jai Kirshan Ravi ◽

Sajeer Bhura ◽

...

Keyword(s):

Liver Injury ◽

Acute Hepatitis ◽

Injection Site ◽

Half Life ◽

Thyroid Dysfunction ◽

Liver Enzymes ◽

Acute Liver Injury ◽

Hepatic Toxicity ◽

Intravenous Amiodarone

Amiodarone is a lipophilic structure with a half-life of 25–100 days. Long-term oral amiodarone is associated with photosensitivity, thyroid dysfunction, and pulmonary and hepatic toxicity. Intravenous amiodarone can lead to sweating, heating sensation, nausea, phlebitis at the injection site, and rarely acute hepatitis. This is a compelling case of a 60-year-old male who developed acute liver injury 24–36 h after starting amiodarone. All the possible causes of acute liver injury were ruled out, and his liver enzymes improved after discontinuing amiodarone.

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Drug-Induced Autoimmune Hepatitis following Treatment with Zoledronic Acid

Case Reports in Gastroenterology ◽

10.1159/000479314 ◽

2017 ◽

Vol 11 (2) ◽

pp. 440-445 ◽

Cited By ~ 4

Author(s):

Jenny Sarah Schneider ◽

Matteo Montani ◽

Felix Stickel

Keyword(s):

Liver Disease ◽

Zoledronic Acid ◽

Side Effects ◽

Liver Injury ◽

Drug Reactions ◽

Drug Induced ◽

Drug Induced Liver Injury ◽

First Case ◽

Alternative Drugs

Adverse drug reactions are among the most frequent side effects of synthetic and complementary alternative drugs and represent the premier causes of license revocations and acute liver failure. Drug-induced liver injury can resemble literally any other genuine liver disease and usually responds well to drug dechallenge. However, in some cases autoimmune-like hepatitis can evolve, requiring short- and sometimes long-term immunosuppression. Here, we present the hitherto first case of autoimmune-like hepatitis following treatment with zoledronic acid.

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Short- or long-term high-fat diet feeding plus acute ethanol binge synergistically induce acute liver injury in mice: An important role for CXCL1

Hepatology ◽

10.1002/hep.27921 ◽

2015 ◽

Vol 62 (4) ◽

pp. 1070-1085 ◽

Cited By ~ 76

Author(s):

Binxia Chang ◽

Ming-Jiang Xu ◽

Zhou Zhou ◽

Yan Cai ◽

Man Li ◽

...

Keyword(s):

Liver Injury ◽

High Fat Diet ◽

Acute Liver Injury ◽

High Fat ◽

Acute Ethanol

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A Patient with Nafcillin-Associated Drug-Induced Liver Failure

Case Reports in Gastroenterology ◽

10.1159/000480071 ◽

2017 ◽

Vol 11 (3) ◽

pp. 564-568 ◽

Cited By ~ 1

Author(s):

Qin Rao ◽

Isaiah Schuster ◽

Talal Seoud ◽

Kevin Zarrabi ◽

Nirvani Goolsarran

Keyword(s):

Liver Injury ◽

Liver Function ◽

Liver Failure ◽

Acute Liver Injury ◽

Early Recognition ◽

Antibiotic Use ◽

Liver Function Tests ◽

The United States ◽

Drug Induced ◽

Drug Induced Liver Injury

Nafcillin-induced acute liver injury is a rare and potentially fatal complication that has been known since the 1960s but inadequately studied. At this time, the only proven treatment is early discontinuation of the drug. Because of the high prevalence of nafcillin class antibiotic use in the United States, it is important for clinicians to have a high clinical suspicion for this diagnosis. We present a case of liver failure attributable to nafcillin use in a 68-year-old male with a history methicillin-sensitive Staphylococcus and L3/L4 osteomyelitis. After starting long-term antibiotic therapy, he presented with painless jaundice which necessitated discontinuation of the drug. At the time of presentation, the patient’s lab work exhibited a bilirubin/direct bilirubin of 9.4/8.2 mg/dL, alkaline phosphatase of 311 IU/L, and aspartate transaminase/alanine transaminase of 109/127 IU/L. The patient was switched to i.v. vancomycin given the concern for drug-induced liver injury. Imaging did not show obstruction of the hepatobiliary or pancreaticobiliary trees. Serology was unremarkable for viral etiology, autoimmune processes, Wilson disease, and hemochromatosis. A liver biopsy showed findings consistent with drug-induced liver injury. The patient’s liver function tests peaked at day 7 of admission and trended towards normal levels with cessation of nafcillin therapy. The patient was discharged with a diagnosis of nafcillin-induced acute liver injury. Our case highlights the importance of early recognition of the diagnosis and careful monitoring of liver function when nafcillin is employed in the clinical setting.

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