Heart-Model-Based Automated Method for Left Ventricular Measurements in Cardiac MR: Comparison with Manual and Semi-automated Methods

2013 ◽  
Vol 17 (3) ◽  
pp. 200
Author(s):  
Seung Hoon Chae ◽  
Whal Lee ◽  
Eun-Ah Park ◽  
Jin Wook Chung
Keyword(s):  
Left Ventricular ◽  
Heart Model ◽  
Cardiac Mr ◽  
Model Based ◽  
Automated Method ◽  
Automated Methods

Towards model-based analysis of cardiac MR tagging data: Relation between left ventricular shear strain and myofiber orientation

2006 ◽  
Vol 10 (4) ◽  
pp. 632-641 ◽  
Author(s):  
S.W.J. Ubbink ◽  
P.H.M. Bovendeerd ◽  
T. Delhaas ◽  
T. Arts ◽  
F.N. van de Vosse
Keyword(s):  
Shear Strain ◽  
Left Ventricular ◽  
Cardiac Mr ◽  
Model Based ◽  
Model Based Analysis

Feasibility and Evaluation of Automated Methods for Radiolabeling of Radiopharmaceutical Kits with Gallium-68

2019 ◽  
Vol 12 (3) ◽  
pp. 229-237 ◽  
Author(s):  
Alban Revy ◽  
François Hallouard ◽  
Sandrine Joyeux-Klamber ◽  
Andrea Skanjeti ◽  
Catherine Rioufol ◽  
...  
Keyword(s):  
The European Union ◽  
Preparation Time ◽  
Limit Of Quantification ◽  
Manual Method ◽  
Personnel Costs ◽  
Automated Method ◽  
Gallium 68 ◽  
The Right ◽  
First Time ◽  
Automated Methods

Objective: Recent gallium-68 labeled peptides are of increasing interest in PET imaging in nuclear medicine. Somakit TOC® is a radiopharmaceutical kit registered in the European Union for the preparation of [68Ga]Ga-DOTA-TOC used for the diagnosis of neuroendocrine tumors. Development of a labeling process using a synthesizer is particularly interesting for the quality and reproducibility of the final product although only manual processes are described in the Summary of Product (SmPC) of the registered product. The aim of the present study was therefore to evaluate the feasibility and value of using an automated synthesizer for the preparation of [68Ga]Ga-DOTA-TOC according to the SmPC of the Somakit TOC®. Methods: Three methods of preparation were compared; each followed the SmPC of the Somakit TOC®. Over time, overheads, and overexposure were evaluated for each method. Results: Mean±SD preparation time was 26.2±0.3 minutes for the manual method, 28±0.5 minutes for the semi-automated, and 40.3±0.2 minutes for the automated method. Overcost of the semi-automated method is 0.25€ per preparation for consumables and from 0.58€ to 0.92€ for personnel costs according to the operator (respectively, technician or pharmacist). For the automated method, overcost is 70€ for consumables and from 4.06€ to 6.44€ for personnel. For the manual method, extremity exposure was 0.425mSv for the right finger, and 0.350mSv for the left finger; for both the semi-automated and automated method extremity exposure were below the limit of quantification. Conclusion: The present study reports for the first time both the feasibility of using a [68Ga]- radiopharmaceutical kit with a synthesizer and the limits for the development of a fully automated process.

Dobutamine responsiveness, PET mismatch, and lack of necrosis in low-flow ischemia: is this hibernation in the isolated rat heart?

2003 ◽  
Vol 285 (1) ◽  
pp. H316-H324 ◽  
Author(s):  
Richard Southworth ◽  
Pamela B. Garlick
Keyword(s):  
Rat Heart ◽  
Recovery Of Function ◽  
Electron Microscopic Examination ◽  
Left Ventricular ◽  
Isolated Rat Heart ◽  
Low Flow ◽  
Hibernating Myocardium ◽  
Heart Model ◽  
Electron Microscopic ◽  
Isolated Rat

The clinical hallmarks of hibernating myocardium include hypocontractility while retaining an inotropic reserve (using dobutamine echocardiography), having normal or increased [18F]fluoro-2-deoxyglucose-6-phosphate (18FDG6P) accumulation associated with decreased coronary flow [flow-metabolism mismatch by positron emission tomography (PET)], and recovering completely postrevascularization. In this study, we investigated an isolated rat heart model of hibernation using experimental equivalents of these clinical techniques. Rat hearts ( n = 5 hearts/group) were perfused with Krebs-Henseleit buffer for 40 min at 100% flow and 3 h at 10% flow and reperfused at 100% flow for 30 min (paced at 300 beats/min throughout). Left ventricular developed pressure fell to 30 ± 8% during 10% flow and recovered to 90 ± 7% after reperfusion. In an additional group, this recovery of function was found to be preserved over 2 h of reperfusion. Electron microscopic examination of hearts fixed at the end of the hibernation period demonstrated a lack of ischemic injury and an accumulation of glycogen granules, a phenomenon observed clinically. In a further group, hearts were challenged with dobutamine during the low-flow period. Hearts demonstrated an inotropic reserve at the expense of increased lactate leakage, with no appreciable creatine kinase release. PET studies used the same basic protocol in both dual- and globally perfused hearts (with 250MBq18FDG in Krebs buffer ± 0.4 mmol/l oleate). PET data showed flow-metabolism “mismatch;” whether regional or global,18FDG6P accumulation in ischemic tissue was the same as (glucose only) or significantly higher than (glucose + oleate) control tissue (0.023 ± 0.002 vs. 0.011 ± 0.002 normalized counts · s-1· g-1· min-1, P < 0.05) despite receiving 10% of the flow. This isolated rat heart model of acute hibernation exhibits many of the same characteristics demonstrated clinically in hibernating myocardium.

scholarly journals Adverse Left Ventricular Remodeling and Age Assessed with Cardiac MR Imaging: The Multi-Ethnic Study of Atherosclerosis

Radiology ◽  
2016 ◽  
Vol 278 (3) ◽  
pp. 714-722 ◽  
Author(s):  
John Eng ◽  
Robyn L. McClelland ◽  
Antoinette S. Gomes ◽  
W. Gregory Hundley ◽  
Susan Cheng ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Ventricular Remodeling ◽  
Left Ventricular Remodeling ◽  
Left Ventricular ◽  
Ethnic Study ◽  
Cardiac Mr

scholarly journals 152 Real-time cardiac MR anatomy and dyssynchrony overlay to guide left ventricular lead placement in CRT

Heart ◽  
2011 ◽  
Vol 97 (Suppl 1) ◽  
pp. A84-A85
Author(s):  
A. Shetty ◽  
S. Duckett ◽  
M. Ginks ◽  
Y. Ma ◽  
M. Sohal ◽  
...  
Keyword(s):  
Real Time ◽  
Left Ventricular ◽  
Left Ventricular Lead ◽  
Cardiac Mr ◽  
Lead Placement ◽  
Ventricular Lead ◽  
Left Ventricular Lead Placement

scholarly journals Counting Mixed Breeding Aggregations of Animal Species Using Drones: Lessons from Waterbirds on Semi-Automation

2020 ◽  
Vol 12 (7) ◽  
pp. 1185 ◽  
Author(s):  
Roxane J. Francis ◽  
Mitchell B. Lyons ◽  
Richard T. Kingsford ◽  
Kate J. Brandis
Keyword(s):  
Animal Species ◽  
Okavango Delta ◽  
Detection Accuracy ◽  
Counting Method ◽  
Breeding Colony ◽  
General Applicability ◽  
Automated Method ◽  
Waterbird Species ◽  
Manual Counting ◽  
Automated Methods

Using drones to count wildlife saves time and resources and allows access to difficult or dangerous areas. We collected drone imagery of breeding waterbirds at colonies in the Okavango Delta (Botswana) and Lowbidgee floodplain (Australia). We developed a semi-automated counting method, using machine learning, and compared effectiveness of freeware and payware in identifying and counting waterbird species (targets) in the Okavango Delta. We tested transferability to the Australian breeding colony. Our detection accuracy (targets), between the training and test data, was 91% for the Okavango Delta colony and 98% for the Lowbidgee floodplain colony. These estimates were within 1–5%, whether using freeware or payware for the different colonies. Our semi-automated method was 26% quicker, including development, and 500% quicker without development, than manual counting. Drone data of waterbird colonies can be collected quickly, allowing later counting with minimal disturbance. Our semi-automated methods efficiently provided accurate estimates of nesting species of waterbirds, even with complex backgrounds. This could be used to track breeding waterbird populations around the world, indicators of river and wetland health, with general applicability for monitoring other taxa.

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