scholarly journals Recurrent Methotrexate-related Lymphoproliferative Disorder of the Lumbar Spine Origin: A Case Report

2021 ◽  
Vol 11 (3) ◽  
Author(s):  
Shun Okuwaki ◽  
Masafumi Uesugi ◽  
Masao Koda ◽  
Naoya Kikuchi ◽  
Masashi Yamazaki
Keyword(s):  
Case Report ◽  
Lumbar Spine ◽  
Lymphoproliferative Disorder ◽  
Interleukin 2 ◽  
Standard Regimen ◽  
Histologic Subtype ◽  
Positron Emission ◽  
Lymph Node Swelling ◽  
Keywords Rheumatoid Arthritis

Introduction: Previously, we reported a relatively rare case of methotrexate-related lymphoproliferative disorder (MTX-LPD) that developed in the lumbar spine. At present, we report the follow-up of that case, presenting with relapse of MTX-LPD. Case Report: The participant was a 75-year-old woman who was diagnosed with MTX-LPD of the lumbar spine and in whom remission was obtained 6 months after discontinuing methotrexate (MTX). At 12 months after remission, elevated levels of soluble interleukin-2 receptor, lymph node swelling on plain computed tomography (CT), and fluorodeoxyglucose uptake on positron emission tomography CT were observed, and recurrent MTX-LPD was diagnosed. Doxorubicin, bleomycin, vinblastine, and dacarbazine therapy was initiated, and partial remission was obtained 6 months later. Conclusion: In MTX-LPD, remission is often achieved following discontinuation of MTX alone; however, some patients do not improve, and some patients relapse, as seen in the present case. Such cases are treated using the standard regimen for the observed histologic subtype. Even after remission has been achieved, strict follow-up observation is needed for MTX-LPD. Furthermore, when signs of recurrence are observed during follow-up, practitioners should endeavor to cooperate with other specialists and act without delay. Keywords: Rheumatoid arthritis, methotrexate, lymphoproliferative disorder, lumbar spine, oncology.

scholarly journals Primary cutaneous CD4+ small/medium T-cell lymphoma: a case report

2021 ◽  
Vol 22 (4) ◽  
pp. 199-203
Author(s):  
Jeenam Kim ◽  
Minkyoung Jeong ◽  
Dongkeun Jun ◽  
Myungchul Lee ◽  
Donghyeok Shin ◽  
...  
Keyword(s):  
Case Report ◽  
T Cell ◽  
Lymphoproliferative Disorder ◽  
Cell Lymphoma ◽  
Surgical Excision ◽  
Lymphoid Cells ◽  
The Face ◽  
Single Mass ◽  
Histopathologic Findings

Primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder is a rare disease characterized by a single mass on the face or upper part of the trunk. It usually presents an asymptomatic and favorable progression, and its histopathologic findings include small and medium-sized lymphoid cells. The authors report a case of primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder on the forehead. A 51-year-old man presented with a protruding mass on his forehead that the patient had noted 1 month previously. Surgical excision and a permanent biopsy were performed under local anesthesia. Based on the biopsy results, the mass was diagnosed as a primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder. There was no evidence of recurrence at a 15-month follow-up visit.

scholarly journals Post-transplant Lymphoproliferative Disorder in a Patient After Kidney Transplant, 5-Year Follow-up: A Case Report

2020 ◽  
Vol 52 (8) ◽  
pp. 2517-2519 ◽  
Author(s):  
Ewa Ignacak ◽  
Joanna Sułowicz ◽  
Agnieszka Giza ◽  
Dominik Cieniawski ◽  
Marek Kuźniewski ◽  
...  
Keyword(s):  
Case Report ◽  
Kidney Transplant ◽  
Lymphoproliferative Disorder ◽  
Post Transplant

scholarly journals Correction of a double spondylolisthesis of the lumbar spine utilizing Chiropractic BioPhysics® technique: a case report with 1 year follow-up

2021 ◽  
Vol 33 (1) ◽  
pp. 89-93
Author(s):  
Curtis A. Fedorchuk ◽  
Douglas F. Lightstone ◽  
Paul A. Oakley ◽  
Deed E. Harrison
Keyword(s):  
Case Report ◽  
Lumbar Spine

scholarly journals Effect of clarithromycin in von Hippel-Lindau syndrome: a case report

2018 ◽  
Vol 47 (2) ◽  
pp. 973-981 ◽  
Author(s):  
Xin Ma ◽  
Yuanyuan Jing ◽  
Yan Liu ◽  
Lisheng Yu
Keyword(s):  
Case Report ◽  
Malignant Tumors ◽  
Germline Mutations ◽  
Pancreatic Tumors ◽  
Von Hippel Lindau ◽  
First Case ◽  
Lymph Node Swelling ◽  
Von Hippel Lindau Syndrome ◽  
Relevant Family History

Von Hippel-Lindau (VHL) syndrome is caused by germline mutations in the VHL gene and is accompanied by the development of both benign and malignant tumors. Clarithromycin (CAM) is a widely used anti-inflammatory drug that has also been proven effective for treating some cancers. In this study, we present a novel case of a 38-year-old female patient with VHL syndrome confirmed by computed tomography, with no relevant family history. The patient was only offered close follow-up observation after diagnosis, but was orally administered CAM twice daily when her disease progressed. After treatment for 3 months, her inner ear tumors had stopped growing and her kidney cysts had shrunk. Her pancreatic tumors treated with CAM showed no significant increase in size, and the lymph node swelling disappeared. CAM treatment was interrupted for 2 years and then stopped for 5 years when improvements were noted; the patient’s condition thereafter gradually improved and finally stabilized with no obvious side effects. We discuss this case in the context of the published literature and consider the possible mechanisms of CAM action in the treatment of VHL syndrome. To our knowledge, this is the first case report of a patient with VHL syndrome treated with CAM.

Intensive Stuttering Therapy With Telepractice Follow-up: A Case Study

2011 ◽  
Vol 21 (1) ◽  
pp. 11-21 ◽  
Author(s):  
Farzan Irani ◽  
Rodney Gabel
Keyword(s):  
Case Report ◽  
Therapeutic Intervention ◽  
Intensive Therapy ◽  
Positive Outcome ◽  
Eclectic Approach

This case report describes the positive outcome of a therapeutic intervention that integrated an intensive, residential component with follow-up telepractice for a 21 year old male who stutters. This therapy utilized an eclectic approach to intensive therapy in conjunction with a 12-month follow-up via video telepractice. The results indicated that the client benefited from the program as demonstrated by a reduction in percent stuttered syllables, a reduction in stuttering severity, and a change in attitudes and feelings related to stuttering and speaking.

Sign in / Sign up

Export Citation Format

Share Document