scholarly journals Primary cutaneous CD4+ small/medium T-cell lymphoma: a case report

2021 ◽  
Vol 22 (4) ◽  
pp. 199-203
Author(s):  
Jeenam Kim ◽  
Minkyoung Jeong ◽  
Dongkeun Jun ◽  
Myungchul Lee ◽  
Donghyeok Shin ◽  
...  
Keyword(s):  
Case Report ◽  
T Cell ◽  
Lymphoproliferative Disorder ◽  
Cell Lymphoma ◽  
Surgical Excision ◽  
Lymphoid Cells ◽  
The Face ◽  
Single Mass ◽  
Histopathologic Findings

Primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder is a rare disease characterized by a single mass on the face or upper part of the trunk. It usually presents an asymptomatic and favorable progression, and its histopathologic findings include small and medium-sized lymphoid cells. The authors report a case of primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder on the forehead. A 51-year-old man presented with a protruding mass on his forehead that the patient had noted 1 month previously. Surgical excision and a permanent biopsy were performed under local anesthesia. Based on the biopsy results, the mass was diagnosed as a primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder. There was no evidence of recurrence at a 15-month follow-up visit.

Primary Cutaneous CD4+ Small/Medium Pleomorphic T-Cell Lymphoproliferative Disorder: A Case Series

2017 ◽  
Vol 21 (6) ◽  
pp. 502-506 ◽  
Author(s):  
Martina Maurelli ◽  
Chiara Colato ◽  
Paolo Gisondi ◽  
Giampiero Girolomoni
Keyword(s):  
T Cell ◽  
Lymphoproliferative Disorder ◽  
Clinical Course ◽  
Case Series ◽  
Surgical Excision ◽  
Cell Receptor ◽  
Spontaneous Resolution ◽  
Review Of The Literature ◽  
The Face

Background: Primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder (CD4+ PCSM-LPD) is defined by a predominance of small- to medium-sized CD4+ pleomorphic T cells and a favorable clinical course. Objective: We performed a retrospective analysis of 6 patients with CD4+ PCSM-LPD and reviewed the literature to address questions about its diagnosis, treatment, and prognosis. Methods: Patients were 3 men and 3 women with a median age of 50 years. All patients presented with a single erythematous nodule, localised on the head in 4 patients and the upper trunk in 2 cases. No patients showed extracutaneous disease at any evaluation. Histopathologic features were characterised by nodular, diffuse, or, in 1 case, a superficial dense infiltrate of small/medium-sized pleomorphic CD4+/PD1+ T lymphocytes. T-cell receptor clonality was demonstrated in 5 cases. Treatment was surgical excision in 5 cases and radiotherapy in 1 case. Results: All patients achieved complete resolution without relapses, during a median follow-up of 3 years. A review of the literature confirmed that CD4+ PCSM-LPD presents predominantly with a solitary nodular lesion on the face, neck, or upper trunk in adult patients. Surgical excision is the preferred treatment. Spontaneous resolution after biopsy may occur. Conclusions: CD4+ PCSM-LPD is a rare disorder with a favorable course.

NK-Cell enteropathy: A novel indolent mimic of enteropathy-associated T-cell lymphoma. Case report with long-term follow-up

2011 ◽  
Vol 49 (05) ◽  
Author(s):  
A Kirchgatterer ◽  
K Kupplent ◽  
G Schmid ◽  
F Hietler ◽  
C Baldinger ◽  
...  
Keyword(s):  
Case Report ◽  
T Cell ◽  
Nk Cell ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Long Term Follow Up

scholarly journals Primary cutaneous CD4+ small/medium-sized pleomorphic T-cell lymphoma in the practice of a dermatologist: A case report

2021 ◽  
Vol 12 (e) ◽  
pp. e67-e67
Author(s):  
Igor Kuklin ◽  
Nikolay Kungurov ◽  
Natalia Zilberberg ◽  
Muza Kokhan ◽  
Galina Safonova ◽  
...  
Keyword(s):  
Case Report ◽  
T Cell ◽  
Skin Biopsy ◽  
Clinical Case ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Laboratory Examination ◽  
The Face ◽  
Immunohistochemical Methods ◽  
Immunohistochemical Studies

The article demonstrates a case of diagnosis of a rare variant of primary skin lymphoma, namely of primary cutaneous CD4+ small/medium-sized pleomorphic T-cell lymphoma with an indolent course. The diagnosis of SMPTCL is based on the combination of the clinical picture, histological and immunomorphological data. A 70-year-old patient presented at the clinic with complaints about tumor-like formations on the skin of the face and back accompanied by moderate itching. The diagnosis was verified by pathomorphological and immunohistochemical studies of the biopsy of the affected skin. The presented clinical case emphasizes the importance of doctors’ clinical oncological alertness and the need for clinical and laboratory examination of the patient using modern histological and immunohistochemical methods for studying the skin biopsy.

scholarly journals Huge B-Cell Lymphoma of the Maxillary Sinus: Case Report and Review of the Litterature

2020 ◽  
pp. 1-2
Author(s):  
Hicham Ngham ◽  
◽  
Lyoubi Hicham ◽  
Keyword(s):  
Case Report ◽  
B Cell ◽  
Maxillary Sinus ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Tumor Stage ◽  
Rare Entity ◽  
External Radiotherapy ◽  
The Face

Primary non-Hodgkin’s lymphoma (NHL) of Paranasal sinus is a rare entity with special characteristics; their locations in the air spaces of the face coming in second row. The prognosis depends on tumor stage and extension into the paranasal sinuses We related the case of a primitive NHL located in the maxillary sinus in a patient of 50 years, invading the entire homolateral nasal cavity. The histopathologic interpretation was B cell lymphoma; the patient received 5 adjuvant chemotherapy treatments according to the CHOP protocol, followed by locoregional external radiotherapy and the evolution was favorable after eighteen months follow-up

Primary cutaneous peripheral T‐cell lymphoma, not otherwise specified, associated with lymphomatoid papulosis after a 9‐year follow up: A case report

2020 ◽  
Vol 47 (6) ◽  
pp. 641-645
Author(s):  
Kyoko Muraoka ◽  
Masakazu Fujimoto ◽  
Yoshifumi Iwahashi ◽  
Ibu Matsuzaki ◽  
Nozomi Yonei ◽  
...  
Keyword(s):  
Case Report ◽  
T Cell ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Peripheral T Cell Lymphoma ◽  
Lymphomatoid Papulosis ◽  
Not Otherwise Specified

scholarly journals Monomorphic Epitheliotropic Intestinal T Cell Lymphoma With Lower Gastrointestinal Hemorrhage: A Case Report and Literature Review

2021 ◽  
Author(s):  
Cheng Zhou ◽  
Lin Yang ◽  
Hai-Juan Xiao ◽  
Xiao-Yan Ma ◽  
Rui-Ni Li ◽  
...  
Keyword(s):  
Case Report ◽  
T Cell ◽  
Cell Lymphoma ◽  
Symptomatic Treatment ◽  
T Cell Lymphoma ◽  
Definite Diagnosis ◽  
Lower Gastrointestinal Hemorrhage ◽  
T Cell Lymphomas ◽  
Small Intestinal

Abstract Enteropathy-associated T cell lymphoma(EATL) is a kind of malignant lymphoma with strong invasiveness. Due to poor effect of conventional symptomatic treatment, the prognosis is not as good as other T-cell lymphomas. A 63-year-old man was admitted to our hospital due to hematochezia. No definite cause was found by electronic gastroscopy and electronic colonoscopy. After symptomatic treatment, the patient's condition did not show significant remission. However, he refused further examination and was discharged. Two months later, the man was admitted to our hospital again due to hematochezia. The site of the lesion was found by capsule endoscopy and small intestinal endoscopy, and the nature of the lesion was confirmed by immunohistochemistry. The patient received chemotherapy and autologous stem cell transplantation after a definite diagnosis. No recurrence or metastasis has been found in an 18-months follow-up after treatment.

scholarly journals Case Report: Composite Angioimmunoblastic T-Cell Lymphoma and Epstein-Barr Virus-Positive B-Cell Lymphoproliferative Disorder as Other Iatrogenic Immunodeficiency-Associated Lymphoproliferative Disorders

2020 ◽  
Vol 7 ◽  
Author(s):  
Seiji Kakiuchi ◽  
Kimikazu Yakushijin ◽  
Ikumi Takagi ◽  
Junpei Rikitake ◽  
Hiroaki Akiyama ◽  
...  
Keyword(s):  
Case Report ◽  
T Cell ◽  
B Cell ◽  
Lymphoproliferative Disorder ◽  
Epstein Barr Virus ◽  
Cell Lymphoma ◽  
Lymphoproliferative Disorders ◽  
Angioimmunoblastic T Cell Lymphoma ◽  
Barr Virus ◽  
Epstein Barr

Immunosuppressants are widely used to treat patients with rheumatoid arthritis (RA), and their adverse effects have been known to cause other iatrogenic immunodeficiency-associated lymphoproliferative disorders (OIIA-LPDs). We report a patient with RA who had been treated with methotrexate (MTX) and tacrolimus (TAC) and who developed whole body lymphadenopathy. We simultaneously confirmed angioimmunoblastic T-cell lymphoma (AITL) through a right cervical lymph node biopsy and Epstein-Barr virus-positive B-cell lymphoproliferative disorder (EBV-positive B-LPD) through a bone marrow examination. After cessation of immunosuppressant therapy, both LPDs completely disappeared. Patients with AITL are occasionally reported to develop B-cell lymphoma through reactivation of the EBV, which leads to clonal expansion in the microenvironment. Immunohistochemistry results revealed that both LPD components were positive for EBV-encoded RNA. Moreover, in this patient, the plasma EBV DNA level was found to be high; therefore, EBV infection was a probable etiology. Synchronous coexistence of AITL and B-LPD as an OIIA-LPD has rarely been reported. This case report is the first to discuss the disappearance of both LPDs on withdrawal of immunosuppressants only. AITL occasionally accompany B-LPD; however, this composite lymphoma comprised AITL and B-LPD, and OIIA-LPDs should not be overlooked.

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