scholarly journals The Inheritance bequeathed to William G. Cochran that he willed forward and left for others to will forward again: The Limits of Observational Studies that seek to Mimic Randomized Experiments

2015 ◽  
Vol 1 (1) ◽  
pp. 141-164
Author(s):  
Thomas D. Cook
2016 ◽  
Vol 5 (1) ◽  
Author(s):  
Stephen R. Cole ◽  
Michael G. Hudgens ◽  
Jessie K. Edwards

AbstractA fundamental probabilistic equivalence between randomized experiments and observational studies is presented. Given a detailed scenario, the reader is asked to consider which of two possible study designs provides more information regarding the expected difference in an outcome due to a time-fixed treatment. A general solution is described, and a particular worked example is also provided. A mathematical proof is given in the appendix. The demonstrated equivalence helps to clarify common ground between randomized experiments and observational studies, and to provide a foundation for considering both the design and interpretation of studies.


Epidemiology ◽  
2008 ◽  
Vol 19 (6) ◽  
pp. 766-779 ◽  
Author(s):  
Miguel A. Hernán ◽  
Alvaro Alonso ◽  
Roger Logan ◽  
Francine Grodstein ◽  
Karin B. Michels ◽  
...  

2020 ◽  
Vol 90 (5-6) ◽  
pp. 535-552 ◽  
Author(s):  
Mahdieh Abbasalizad Farhangi ◽  
Mahdi Vajdi

Abstract. Backgrounds: Central obesity, as a pivotal component of metabolic syndrome is associated with numerous co-morbidities. Dietary factors influence central obesity by increased inflammatory status. However, recent studies didn’t evaluate the association between central obesity and dietary inflammation index (DII®) that give score to dietary factors according to their inflammatory potential. In the current systematic review and meta-analysis, we summarized the studies that investigated the association between DII® with central obesity indices in the general populations. Methods: In a systematic search from PubMed, SCOPUS, Web of Sciences and Cochrane electronic databases, we collected relevant studies written in English and published until 30 October 2019. The population of included studies were apparently healthy subjects or individuals with obesity or obesity-related diseases. Observational studies that evaluated the association between DII® and indices of central obesity including WC or WHR were included. Results: Totally thirty-two studies were included; thirty studies were cross-sectional and two were cohort studies with 103071 participants. Meta-analysis of observational studies showed that higher DII® scores were associated with 1.81 cm increase in WC (Pooled weighted mean difference (WMD) = 1.813; CI: 0.785–2.841; p = 0.001). Also, a non-significant increase in the odds of having higher WC (OR = 1.162; CI: 0.95–1.43; p = 0.154) in the highest DII category was also observed. In subgroup analysis, the continent, dietary assessment tool and gender were the heterogeneity sources. Conclusion: The findings proposed that adherence to diets with high DII® scores was associated with increased WC. Further studies with interventional designs are necessary to elucidate the causality inference between DII® and central obesity indices.


2020 ◽  
Vol 36 (2) ◽  
pp. 410-420 ◽  
Author(s):  
Anthony M. Gibson ◽  
Nathan A. Bowling

Abstract. The current paper reports the results of two randomized experiments designed to test the effects of questionnaire length on careless responding (CR). Both experiments also examined whether the presence of a behavioral consequence (i.e., a reward or a punishment) designed to encourage careful responding buffers the effects of questionnaire length on CR. Collectively, our two studies found (a) some support for the main effect of questionnaire length, (b) consistent support for the main effect of the consequence manipulations, and (c) very limited support for the buffering effect of the consequence manipulations. Because the advancement of many subfields of psychology rests on the availability of high-quality self-report data, further research should examine the causes and prevention of CR.


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