Estimating intracranial pressure using pulsatile cerebral blood flow measured with diffuse correlation spectroscopy: erratum

Objective Hypoxic-ischemic encephalopathy (HIE) in infants can have long-term adverse neurodevelopmental effects and markedly reduce quality of life. Both the initial hypoperfusion and the subsequent rapid reperfusion can cause deleterious effects in brain tissue. Cerebral blood flow (CBF) assessment in newborns with HIE can help detect abnormalities in brain perfusion to guide therapy and prognosticate patient outcomes. Study Design The review will provide an overview of the pathophysiological implications of CBF derangements in neonatal HIE, current and emerging techniques for CBF quantification, and the potential to utilize CBF as a physiologic target in managing neonates with acute HIE. Conclusion The alterations of CBF in infants during hypoxia-ischemia have been studied by using different neuroimaging techniques, including nitrous oxide and xenon clearance, transcranial Doppler ultrasonography, contrast-enhanced ultrasound, arterial spin labeling MRI, 18F-FDG positron emission tomography, near-infrared spectroscopy (NIRS), functional NIRS, and diffuse correlation spectroscopy. Consensus is lacking regarding the clinical significance of CBF estimations detected by these different modalities. Heterogeneity in the imaging modality used, regional versus global estimations of CBF, time for the scan, and variables impacting brain perfusion and cohort clinical characteristics should be considered when translating the findings described in the literature to routine practice and implementation of therapeutic interventions. Key Points

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Calibration of diffuse correlation spectroscopy with a time-resolved near-infrared technique to yield absolute cerebral blood flow measurements: errata

Biomedical Optics Express ◽

10.1364/boe.3.001476 ◽

2012 ◽

Vol 3 (6) ◽

pp. 1476 ◽

Cited By ~ 6

Author(s):

Mamadou Diop ◽

Kyle Verdecchia ◽

Ting-Yim Lee ◽

Keith St Lawrence

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Near Infrared ◽

Correlation Spectroscopy ◽

Flow Measurements ◽

Time Resolved ◽

Diffuse Correlation Spectroscopy ◽

Blood Flow Measurements

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Cerebral Blood Flow Monitoring in Preterm Infants by Diffuse Correlation Spectroscopy

Biomedical Optics 2014 ◽

10.1364/biomed.2014.bs3a.33 ◽

2014 ◽

Author(s):

Mamadou Diop ◽

Jessica Kishimoto ◽

David S. C. Lee ◽

Ting-Yim Lee ◽

Keith St. Lawrence

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Preterm Infants ◽

Correlation Spectroscopy ◽

Diffuse Correlation Spectroscopy ◽

Flow Monitoring

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Impact of errors in optical properties and/or geometry on the recovery of cerebral blood flow using diffuse correlation spectroscopy

Biomedical Optics 2016 ◽

10.1364/cancer.2016.jtu3a.20 ◽

2016 ◽

Author(s):

S.A. Carp ◽

D.A. Boas ◽

J. Selb

Keyword(s):

Blood Flow ◽

Optical Properties ◽

Cerebral Blood Flow ◽

Correlation Spectroscopy ◽

Diffuse Correlation Spectroscopy

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Prolonged monitoring of cerebral blood flow and autoregulation with diffuse correlation spectroscopy in neurocritical care patients

Neurophotonics ◽

10.1117/1.nph.5.4.045005 ◽

2018 ◽

Vol 5 (04) ◽

pp. 1 ◽

Cited By ~ 7

Author(s):

Juliette Selb ◽

Kuan-Cheng Wu ◽

Jason Sutin ◽

Pei-Yi (Ivy) Lin ◽

Parisa Farzam ◽

...

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Neurocritical Care ◽

Correlation Spectroscopy ◽

Diffuse Correlation Spectroscopy ◽

Prolonged Monitoring

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Noninvasive Optical Monitoring of Cerebral Blood Flow and EEG Spectral Responses after Severe Traumatic Brain Injury: A Case Report

Brain Sciences ◽

10.3390/brainsci11081093 ◽

2021 ◽

Vol 11 (8) ◽

pp. 1093

Author(s):

Chien-Sing Poon ◽

Benjamin Rinehart ◽

Dharminder S. Langri ◽

Timothy M. Rambo ◽

Aaron J. Miller ◽

...

Keyword(s):

Traumatic Brain Injury ◽

Blood Flow ◽

Cerebral Blood Flow ◽

Brain Injury ◽

Brain Activity ◽

Correlation Spectroscopy ◽

Secondary Brain Injury ◽

Diffuse Correlation Spectroscopy ◽

Flow Monitoring ◽

And Function

Survivors of severe brain injury may require care in a neurointensive care unit (neuro-ICU), where the brain is vulnerable to secondary brain injury. Thus, there is a need for noninvasive, bedside, continuous cerebral blood flow monitoring approaches in the neuro-ICU. Our goal is to address this need through combined measurements of EEG and functional optical spectroscopy (EEG-Optical) instrumentation and analysis to provide a complementary fusion of data about brain activity and function. We utilized the diffuse correlation spectroscopy method for assessing cerebral blood flow at the neuro-ICU in a patient with traumatic brain injury. The present case demonstrates the feasibility of continuous recording of noninvasive cerebral blood flow transients that correlated well with the gold-standard invasive measurements and with the frequency content changes in the EEG data.

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Abstract TMP86: Early Microvascular Cerebral Blood Flow Response to Head-of-bed Elevation is Related to Outcome in Acute Ischemic Stroke: A Diffuse Correlation Spectroscopy Study

Stroke ◽

10.1161/str.48.suppl_1.tmp86 ◽

2017 ◽

Vol 48 (suppl_1) ◽

Author(s):

Clara Gregori-Pla ◽

Raquel Delgado-Mederos ◽

Pol Camps-Renom ◽

Peyman Zirak ◽

Igor Blanco ◽

...

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Ischemic Stroke ◽

Acute Ischemic Stroke ◽

Correlation Spectroscopy ◽

Stroke Onset ◽

Diffuse Correlation Spectroscopy ◽

Blood Flow Response ◽

Poor Outcome ◽

Flow Response

Introduction: The microvascular cerebral blood flow response (rCBF) to orthostatic stress has been shown to be altered in acute ischemic stroke (AIS) by diffuse correlation spectroscopy (DCS). However, its relevance to the outcome is unknown. Hypothesis: CBF response to head-of-the-bed (HOB) elevation within the first hours after AIS is related to outcome. Methods: Patients with a large anterior circulation stroke of less than 48h from the stroke onset were monitored with DCS to follow rCBF in the frontal lobes during a HOB elevation from supine to 30°. All patients were placed flat during the first 24 hours and later, mobilization was initiated depending on the clinical condition. We categorized measurements as early (<12h) or late (>12h) from stroke onset. NIHSS was recorded at baseline, during HOB, at 24h and 48h. The modified Rankin scale (mRS) score was utilized as the outcome measure (favorable when 0-2). Results: We studied 34 patients (age 78±13y, male 47%, median NIHSS 19 (14-21)) at 16±11 hours from stroke. Ipsilateral extracranial and/or intracranial occlusion was present in 61%. Frontal CBF decreased in both hemispheres after HOB (-5±14%). A paradoxical response (increase/no change) was observed in 18%. rCBF was not correlated to NIHSS and age. Unfavorable outcome was found in 85%. Only at early hours (<12h, n=16), rCBF to HOB elevation in the ipsilateral (not in contralateral) hemisphere (p=0.04, Figure 1) and NIHSS HOB (p=0.008) were associated with poor outcome. Conclusions: This result suggests that paradoxical CBF response to a mild HOB elevation in the early hours of stroke onset is associated with a poor outcome in patients with AIS. Optical continuous monitoring in the bedside may help to individualize management strategies in the early hours of AIS. Figure 1: rCBF due to HOB elevation versus mRS for the ipsi-lateral side in patients measured <12h after stroke.

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