Quantitative Infrared Spectroscopic Measurements of Mixtures without External Calibration

1979 ◽  
Vol 33 (4) ◽  
pp. 349-350 ◽  
Author(s):  
Jack L. Koenig ◽  
Donald Kormos
Keyword(s):  
Concentration Ratio ◽  
Spectroscopic Method ◽  
Spectroscopic Measurements ◽  
External Calibration ◽  
Absorbance Ratio ◽  
Infrared Spectroscopic

A general spectroscopic method for the analysis of mixtures that does not require external calibration has been developed. The method is based on the obtaining of absorbance ratio spectra and the determination of a concentration ratio at frequencies unique to each component. The method is applied to mixtures hexane and cyclohexane.

Regulatory Infrared Spectroscopic Method for the Rapid Determination of Total Isolated Trans Fat: A Collaborative Study

2010 ◽  
Vol 88 (1) ◽  
pp. 39-46 ◽  
Author(s):  
M. M. Mossoba ◽  
A. Seiler ◽  
H. Steinhart ◽  
J. K. G. Kramer ◽  
L. Rodrigues-Saona ◽  
...  
Keyword(s):  
Rapid Determination ◽  
Spectroscopic Method ◽  
Collaborative Study ◽  
Trans Fat ◽  
Infrared Spectroscopic

UV spectroscopic method for determination of phenytoin in bulk and injection forms

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Quality Control ◽  
Spectrophotometric Method ◽  
Spectroscopic Method ◽  
Ich Guidelines ◽  
Precision And Accuracy ◽  
Routine Quality Control

Recent study was conducted to develop a simple UV spectrophotometric method to determine Phenytoin in bulk and injection form according to official requirement and validate as per ICH guidelines. λmax of Phenytoin was found 202 nm. Linearity existed perceived in the concentration assortment 2-8 μg/ml (r2 = 0.999) for the method. The method was validated pertaining to linearity, precision and accuracy studies, LOD and LOQ consistent with ICH guidelines. The existent method was establish to be simple, linear, precise, accurate as well as sensitive and can be applied for routine quality control enquiry for the analysis of Phenytoin in bulk and injection form.

Development and Validation of Derivative Spectroscopic Method for Simultaneous Estimation of Cefadroxil and Probenecid

2014 ◽  
Vol 7 (1) ◽  
pp. 2350-2355
Author(s):  
Pratik S Mehta ◽  
Pratik R. Patel ◽  
Rajesh R Parmar ◽  
M M K Modasiya ◽  
Dushyant A Shah
Keyword(s):  
Spectroscopic Method ◽  
Spectral Interference ◽  
Synthetic Mixture ◽  
Simultaneous Estimation ◽  
Zero Crossing ◽  
First Order ◽  
Derivative Spectroscopy ◽  
Development And Validation ◽  
Crossing Point

A novel, simple, accurate, sensitive, precise and economical derivative spectroscopic method was developed and validated for the determination of cefadroxil and probenecid in synthetic mixture. First order derivative spectroscopy method was adopted to eliminate spectral interference. The method obeys Beer’s Law in concentration ranges of 4-36 μg/ml for cefadroxil and of 5-25 μg/ml of probenecid. The zero crossing point for cefadroxil and probenecid was 260 nm and 237.8 nm respectively in 0.1N HCl. The method was validated in terms of accuracy, precision, linearity, limits of detection, limits of quantitation. This method has been successively applied to synthetic mixture and no interference from the synthetic mixture’s excipients was found.   

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