Determination of Methamphetamine and its Related Compounds Using Fourier Transform Raman Spectroscopy

1997 ◽  
Vol 51 (12) ◽  
pp. 1796-1799 ◽  
Author(s):  
Hitoshi Tsuchihashi ◽  
Munehiro Katagi ◽  
Mayumi Nishikawa ◽  
Michiaki Tatsuno ◽  
Hiroshi Nishioka ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Fourier Transform ◽  
Ephedrine Hydrochloride ◽  
Fourier Transform Raman Spectroscopy ◽  
Plastic Bag ◽  
Amphetamine Sulfate ◽  
Fourier Transform Raman ◽  
Related Compounds ◽  
Ft Raman

Fourier transform Raman spectroscopy (FT-Raman) is investigated as a simple and rapid method for the determination of the abused drug methamphetamine and its related compounds. Compounds can be reliably identified by using measurements made nondestructively and without the need for any sample preparation in around 1 min. The Raman spectrum of methamphetamine hydrochloride (MA) shows clear differences in spectra from a range of its related compounds such as amphetamine sulfate and ephedrine hydrochloride. These differences are adequate for spectral differentiation of the compounds. With the use of the FT-Raman technique, MA is also reliably identifiable to a detection limit of 1% (w/w) diluted in sodium chloride or water. FT-Raman spectra of MA were recorded through plastic packaging (polyethylene or polypropylene bags) typical of that used either by criminals for transportation or by law enforcement for containing and sealing evidence. Measurements could be made directly without removing the drug from the bag; excellent-quality spectra could be obtained with very little perturbation by the plastic bag.

Fourier Transform Raman Spectroscopy of Long-Chain Molecules Containing Strongly Absorbing Chromophores

1987 ◽  
Vol 41 (5) ◽  
pp. 721-726 ◽  
Author(s):  
C. G. Zimba ◽  
V. M. Hallmark ◽  
J. D. Swalen ◽  
J. F. Rabolt
Keyword(s):  
Raman Spectroscopy ◽  
Fourier Transform ◽  
Near Infrared ◽  
Visible Region ◽  
Excitation Spectra ◽  
Chain Molecules ◽  
Scattering Geometry ◽  
Fourier Transform Raman Spectroscopy ◽  
Fourier Transform Raman ◽  
Ft Raman

Fourier transform Raman spectroscopy shows considerable promise as a new characterization technique for molecules which contain chromophores which absorb in the visible region, the region where conventional Raman measurements are made. With the use of near-infrared excitation, spectra in the absence of fluorescence and resonance enhancement are obtained. These advantages can be further enhanced if the collection of data using this technique becomes routine, requiring a level of complexity comparable to that of conventional Raman scattering. Toward that end, the implementation of a 90° scattering geometry in our FT-Raman measurements was undertaken, and the results are shown to be at least comparable to those obtained with the use of reflective optics in a 180° geometry. A number of results on both liquids and solids have also been obtained in order to compare FT-Raman with conventional scanning Raman measurements.

Determination of the Resolution of a Multichannel Raman Spectrometer Using Fourier Transform Raman Spectra

2003 ◽  
Vol 57 (2) ◽  
pp. 190-196 ◽  
Author(s):  
Bryan T. Bowie ◽  
Peter R. Griffiths
Keyword(s):  
Raman Spectroscopy ◽  
Fourier Transform ◽  
Raman Spectra ◽  
Shape Function ◽  
Raman Spectrometer ◽  
Fourier Transform Raman ◽  
Nominal Resolution ◽  
Line Shape Function ◽  
Ft Raman

The resolution of a grating polychromator for Raman spectroscopy has been simulated by measuring spectra on a Fourier transform (FT) Raman spectrometer and selecting the FT of the apodization function so that the instrument line shape function mimics the triangular spectral slit function of the polychromator. To this end, FT-Raman spectra measured with a nominal resolution of 0.5 cm−1 were modified through the application of sinc2 apodization functions of various widths to simulate spectra measured on a polychromator at lower resolution. The success of this approach was validated using the 1085 cm−1 band of calcite. When the modified FT-Raman spectra were compared with spectra measured on a grating polychromator equipped with slits of widths 100 and 150 μm, the resolution of the polychromator was estimated to be 6.3 and 7.8 cm−1, respectively. This conclusion was verified experimentally by measuring the separation of two bands in the Raman spectrum of BaSO4 at ∼460 cm−1

Investigation of Normal and Malignant Tissue Samples from the Human Stomach Using Fourier Transform Raman Spectroscopy

2002 ◽  
Vol 56 (5) ◽  
pp. 570-573 ◽  
Author(s):  
X.-F. Ling ◽  
Y.-Z. Xu ◽  
S.-F. Weng ◽  
W. H. Li ◽  
Xu Zhi ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Fourier Transform ◽  
Normal Tissue ◽  
Human Stomach ◽  
Malignant Tissue ◽  
Tissue Samples ◽  
Fourier Transform Raman Spectroscopy ◽  
Spectroscopic Identification ◽  
Fourier Transform Raman ◽  
Ft Raman

Fourier transform (FT) Raman studies of 40 tissue samples from the human stomach, including 22 normal and 18 malignant tissue samples, were performed. These stomach tissue samples had been classified as normal or malignant on the basis of pathological studies and biopsy detection. The results indicate that a series of major bands in the FT-Raman spectrum can be used to distinguish the malignant tissue from the normal tissue. Subtraction spectra support the result of the spectroscopic identification. Statistical analysis is also in agreement with the FT-Raman measurements.

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