Noninvasive Assessment of Regional and Temporal Variations in Tissue Oxygenation by Near-Infrared Spectroscopy and Imaging

1997 ◽  
Vol 51 (2) ◽  
pp. 143-152 ◽  
Author(s):  
Michael G. Sowa ◽  
James R. Mansfield ◽  
Gordon B. Scarth ◽  
Henry H. Mantsch
Keyword(s):  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Tissue Oxygenation ◽  
Infrared Imaging ◽  
Temporal Variations ◽  
Tissue Oxygen Saturation ◽  
Venous Outflow ◽  
Fuzzy C Means Clustering ◽  
Time Courses

A combination of near-infrared spectroscopy and discrete wavelength near-infrared imaging is used to noninvasively monitor the forearm during periods of restricted blood outflow (venous outflow restriction) and interrupted blood inflow (ischemia). Multivariate analysis of image and spectral data time courses was used to identify highly correlated spectral and regional domains, while fuzzy C-means clustering of image time courses was used to reveal finer regional heterogeneities in the response of stressed tissues. Localized near-infrared spectroscopy was used to investigate the magnitude of the bulk changes in the tissue optical properties and the variation in tissue oxygenation saturation during venous outflow restriction and complete forearm ischemia. The imaging and spectroscopic analyses revealed highly localized regional variations in tissue oxygen saturation during forearm ischemia as compared to the more diffuse and global response of the forearm during venous outflow restriction.

scholarly journals Evaluation of Different Near-Infrared Spectroscopy Devices for Assessing Tissue Oxygenation with a Vascular Occlusion Test in Healthy Volunteers

2020 ◽  
Vol 57 (6) ◽  
pp. 341-347
Author(s):  
Jaeyeon Chung ◽  
Sang-Hwan Ji ◽  
Young-Eun Jang ◽  
Eun-Hee Kim ◽  
Ji-Hyun Lee ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Pairwise Comparison ◽  
Vascular Occlusion ◽  
Tissue Oxygen Saturation ◽  
Vascular Occlusion Test ◽  
Occlusion Test ◽  
Significant Difference ◽  
Post Hoc

Near-infrared spectroscopy devices can measure peripheral tissue oxygen saturation (StO<sub>2</sub>). This study aims to compare StO<sub>2</sub> using INVOS® and different O3™ settings (O3<sup>25:75</sup> and O3<sup>30:70</sup>). Twenty adults were recruited. INVOS® and O3™ probes were placed simultaneously on 1 side of forearm. After baseline measurement, the vascular occlusion test was initiated. The baseline value, rate of deoxygenation and reoxygenation, minimum and peak StO<sub>2</sub>, and time from cuff release to peak value were measured. The parameters were compared using ANOVA and Kruskal-Wallis tests. Bonferroni’s correction and Mann-Whitney pairwise comparison were used for post hoc analysis. The agreement between StO<sub>2</sub> of devices was evaluated using Bland-Altman plots. INVOS® baseline value was higher (79.7 ± 6.4%) than that of O3<sup>25:75</sup> and O3<sup>30:70</sup> (62.4 ± 6.0% and 63.7 ± 5.5%, respectively, <i>p</i> &#x3c; 0.001). The deoxygenation rate was higher with INVOS® (10.6 ± 2.1%/min) than with O3<sup>25:75</sup> and O3<sup>30:70</sup> (8.4 ± 2.2%/min, <i>p</i> = 0.006 and 7.5 ± 2.1%/min, <i>p</i> &#x3c; 0.001). The minimum and peak StO<sub>2</sub> were higher with INVOS®. No significant difference in the reoxygenation rate was found between the devices and settings. The time to reach peak after cuff deflation was faster with INVOS® (both <i>p</i> &#x3c; 0.001). Other parameters were similar. There were no differences between the different O3™ settings. There were differences in StO<sub>2</sub> measurements between the devices, and these devices should not be interchanged. Differences were not observed between O3™ device settings.

Evaluating the dynamics of brain tissue oxygenation using near-infrared spectroscopy on various experimental models

2019 ◽  
Vol 16 (11) ◽  
pp. 115602
Author(s):  
D M Kustov ◽  
A S Sharova ◽  
V I Makarov ◽  
A V Borodkin ◽  
T A Saveleva ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Brain Tissue ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Tissue Oxygenation ◽  
Experimental Models ◽  
Brain Tissue Oxygenation

scholarly journals Near-infrared spectroscopy monitoring tissue oxygen saturation after cardiac surgery

Critical Care ◽  
2009 ◽  
Vol 13 (Suppl 1) ◽  
pp. P239
Author(s):  
R Kopp ◽  
S Rex ◽  
K Dommann ◽  
G Schälte ◽  
G Dohmen ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Infrared Spectroscopy ◽  
Oxygen Saturation ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Tissue Oxygen Saturation ◽  
Tissue Oxygen

scholarly journals Tissue Oximeter with Selectable Measurement Depth Using Spatially Resolved Near-Infrared Spectroscopy

Sensors ◽  
2021 ◽  
Vol 21 (16) ◽  
pp. 5573
Author(s):  
Masatsugu Niwayama ◽  
Naoki Unno
Keyword(s):  
Infrared Spectroscopy ◽  
Light Source ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Subcutaneous Tissue ◽  
Tissue Oxygen Saturation ◽  
Measurement Sensitivity ◽  
Phantom Experiment ◽  
Spatially Resolved ◽  
Measurement Depth

Tissue oxygenation sensing at a few millimeters deep is useful for surgical and postoperative management. However, the measurement sensitivity at each depth and the proper sensor combination have not been clarified. Here, the measurement characteristics of oximetry by spatially resolved near-infrared spectroscopy were analyzed using Monte Carlo simulation and phantom experiment. From summing the sensitivities of each depth, it was quantitatively found that the measurement sensitivity curve had a peak, and the measurement depth can be adjusted by combining the two distances between the light source and the detector. Furthermore, the gastric tissue was 10–20% smaller in terms of measurement depth than the skin-subcutaneous tissue. A miniaturized oximeter was prototyped so that it could be used in combination with an endoscope or laparoscope. The optical probes consisted of light emitting diodes with wavelengths of 770 nm and 830 nm and photodetectors located 3 to 30 mm from the light source. Phantom experiments using the probes demonstrated the tendency of theoretical analysis. These results suggest the possibility of measuring tissue oxygen saturation with a selectable measurement depth. This selectable method will be useful for obtaining oxygenation information at a depth of 2–5 mm, which is difficult to measure using only laparoscopic surface imaging.

scholarly journals Near-Infrared Spectroscopy in Extremely Preterm Infants

2021 ◽  
Vol 8 ◽  
Author(s):  
Leeann R. Pavlek ◽  
Clifford Mueller ◽  
Maria R. Jebbia ◽  
Matthew J. Kielt ◽  
Omid Fathi
Keyword(s):  
Infrared Spectroscopy ◽  
Preterm Infants ◽  
Near Infrared Spectroscopy ◽  
Neonatal Intensive Care ◽  
Near Infrared ◽  
Tissue Oxygen Saturation ◽  
Tissue Oxygen ◽  
Extremely Preterm ◽  
Extremely Preterm Infants ◽  
Potential Applications

With advances in neonatal care, survival of premature infants at the limits of viability has improved significantly. Despite these improvement in mortality, infants born at 22–24 weeks gestation are at a very high risk for short- and long-term morbidities associated with prematurity. Many of these diseases have been attributed to abnormalities of tissue oxygenation and perfusion. Near-infrared spectroscopy utilizes the unique absorption properties of oxyhemoglobin and deoxyhemoglobin to provide an assessment of regional tissue oxygen saturation, which can be used to calculate the fractional tissue oxygen extraction. This allows for a non-invasive way to monitor tissue oxygen consumption and enables targeted hemodynamic management. This mini-review provides a brief and complete overview of the background and physiology of near-infrared spectroscopy, practical use in extremely preterm infants, and potential applications in the neonatal intensive care unit. In this mini-review, we aim to summarize the three primary application sites for near-infrared spectroscopy, disease-specific indications, and available literature regarding use in extremely preterm infants.

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