Program Considerations for Simplex Optimization of Ion Lenses in ICP-MS

1998 ◽  
Vol 52 (5) ◽  
pp. 643-648 ◽  
Author(s):  
Christine Sartoros ◽  
Douglas M. Goltz ◽  
Eric D. Salin
Keyword(s):  
Inductively Coupled Plasma ◽  
Simplex Algorithm ◽  
Ratio Method ◽  
Average Mass ◽  
Target Vector ◽  
Inductively Coupled ◽  
Ion Optics ◽  
Analyte Signal ◽  
Icp Ms ◽  
Signal Intensities

The performance of an inductively coupled plasma mass spectrometer (ICP-MS) is dependent on the ion optic bias potentials. A discussion of the multielement optimization of the ICP-MS ion optics bias potentials using a Simplex algorithm is presented. Three objective functions were tested: a function developed by Leary; the combined ratio method (CRM); and the Euclidean distance from multicriteria target vector optimization. Both the Leary and the target vector optimization's performances were comparable, whereas the CRM optimizations placed an emphasis on obtaining similar signal intensities. Experiments determined that an initial Simplex starting size of 20% of the parameter space was optimal. A method for the selection of an appropriate target vector by predicting analyte signal intensity was also investigated. Signal intensities for all elements could be predicted with an acceptable margin of error (10–30%), provided that the same conditions were used. Comparisons of optimizations using a single mid-mass element vs. multielement optimizations revealed that the multielement approach is only slightly better. If the analyst wished to optimize lens settings to favor heavy or light elements, then an average mass was better than a mid-mass optimization.

Study on carbon-induced signal enhancement in inductively coupled plasma mass spectrometry: an approach from the spatial distribution of analyte signal intensities

2019 ◽  
Vol 34 (9) ◽  
pp. 1865-1874 ◽  
Author(s):  
Tomoko Ariga ◽  
Yanbei Zhu ◽  
Kazumi Inagaki
Keyword(s):  
Spatial Distribution ◽  
Inductively Coupled Plasma ◽  
Signal Enhancement ◽  
Inductively Coupled ◽  
Analyte Signal ◽  
Novel Approach ◽  
Icp Ms ◽  
Plasma Mass Spectrometry ◽  
Induced Signal ◽  
Signal Intensities

This study proposed a novel approach for quantifying carbon-induced signal enhancement in ICP-MS considering the spatial distribution of analyte signal intensities.

Ion Kinetic Energies in Inductively Coupled Plasma/Mass Spectrometry (ICP-MS)

1986 ◽  
Vol 40 (7) ◽  
pp. 971-974 ◽  
Author(s):  
J. E. Fulford ◽  
D. J. Douglas
Keyword(s):  
Inductively Coupled Plasma ◽  
Gas Flow ◽  
Matrix Composition ◽  
Plasma Parameters ◽  
Inductively Coupled ◽  
Sampling Orifice ◽  
Ion Optics ◽  
Icp Ms ◽  
Ion Energies ◽  
Plasma Mass Spectrometry

Ion kinetic energies in an inductively coupled plasma/mass spectrometer (ICP-MS) system have been measured with the use of a retarding potential on the analyzing quadrupole. The energies differ markedly from those previously reported in the literature. This is attributed to the elimination of any arcing of the ICP to the sampling orifice or skimmer of the ICP-MS system. In the absence of secondary discharge effects, the ion energies increase with the mass of the ion and are consistent with those expected from molecular beam sampling from a plasma with a temperature of ∼5000 K and a potential of ∼2 V. Ion energies are found to be virtually independent of aerosol gas flow, plasma power, and sample matrix composition, allowing independent optimization of plasma parameters and ion optics.

Single Particle Inductively Coupled Plasma Mass Spectrometry: Investigating Nonlinear Response Observed in Pulse Counting Mode and Extending the Linear Dynamic Range by Compensating for Dead Time Related Count Losses on a Microsecond Timescale

2019 ◽  
Author(s):  
Ingo Strenge ◽  
Carsten Engelhard
Keyword(s):  
Mass Spectrometry ◽  
Inductively Coupled Plasma ◽  
Nonlinear Response ◽  
Dynamic Range ◽  
Dead Time ◽  
Inorganic Nanoparticles ◽  
Linear Dynamic Range ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

<p>The article demonstrates the importance of using a suitable approach to compensate for dead time relate count losses (a certain measurement artefact) whenever short, but potentially strong transient signals are to be analysed using inductively coupled plasma mass spectrometry (ICP-MS). Findings strongly support the theory that inadequate time resolution, and therefore insufficient compensation for these count losses, is one of the main reasons for size underestimation observed when analysing inorganic nanoparticles using ICP-MS, a topic still controversially discussed.</p>

Fast Turn-around Failure Analysis of Metal Interconnection Using FIB and LA ICP-MS

2010 ◽  
Author(s):  
Zixiao Pan ◽  
Wei Wei ◽  
Fuhe Li
Keyword(s):  
Failure Analysis ◽  
Inductively Coupled Plasma ◽  
Structural Damage ◽  
Focused Ion Beam ◽  
Ion Beam ◽  
Detection Sensitivity ◽  
Chemical Contamination ◽  
Inductively Coupled ◽  
Minimal Sample ◽  
Icp Ms

Abstract This paper introduces our effort in failure analysis of a 200 nm thick metal interconnection on a glass substrate and covered with a passivation layer. Structural damage in localized areas of the metal interconnections was observed with the aid of focused ion beam (FIB) cross-sectioning. Laser ablation inductively coupled plasma mass spectroscopy (LA ICP-MS) was then applied to the problematic areas on the interconnection for chemical survey. LA ICP-MS showed direct evidence of localized chemical contamination, which has likely led to corrosion (or over-etching) of the metal interconnection and the assembly failure. Due to the high detection sensitivity of LA ICP-MS and its compatibility with insulating material analysis, minimal sample preparation is required. As a result, the combination of FIB and LA ICP-MS enabled successful meso-scale failure analysis with fast turnaround and reasonable cost.

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