scholarly journals Correction: An In Vitro Model That Recapitulates the Epithelial to Mesenchymal Transition (EMT) in Human Breast Cancer

PLoS ONE ◽  
2011 ◽  
Vol 6 (4) ◽  
Author(s):  
Elad Katz ◽  
Sylvie Dubois-Marshall ◽  
Andrew H. Sims ◽  
Philippe Gautier ◽  
Helen Caldwell ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
In Vitro Model ◽  
Epithelial To Mesenchymal Transition ◽  
Human Breast ◽  
Mesenchymal Transition ◽  
Vitro Model

scholarly journals Correction: An In Vitro Model That Recapitulates the Epithelial to Mesenchymal Transition (EMT) in Human Breast Cancer

PLoS ONE ◽  
2011 ◽  
Vol 6 (4) ◽  
Author(s):  
Elad Katz ◽  
Sylvie Dubois-Marshall ◽  
Andrew H. Sims ◽  
Philippe Gautier ◽  
Helen Caldwell ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
In Vitro Model ◽  
Epithelial To Mesenchymal Transition ◽  
Human Breast ◽  
Mesenchymal Transition ◽  
Vitro Model

scholarly journals An In Vitro Model That Recapitulates the Epithelial to Mesenchymal Transition (EMT) in Human Breast Cancer

PLoS ONE ◽  
2011 ◽  
Vol 6 (2) ◽  
pp. e17083 ◽  
Author(s):  
Elad Katz ◽  
Sylvie Dubois-Marshall ◽  
Andrew H. Sims ◽  
Philippe Gautier ◽  
Helen Caldwell ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
In Vitro Model ◽  
Epithelial To Mesenchymal Transition ◽  
Human Breast ◽  
Mesenchymal Transition ◽  
Vitro Model

scholarly journals Correction: An In Vitro Model That Recapitulates the Epithelial to Mesenchymal Transition (EMT) in Human Breast Cancer

PLoS ONE ◽  
2011 ◽  
Vol 6 (4) ◽  
Author(s):  
Elad Katz ◽  
Sylvie Dubois-Marshall ◽  
Andrew H. Sims ◽  
Philippe Gautier ◽  
Helen Caldwell ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
In Vitro Model ◽  
Epithelial To Mesenchymal Transition ◽  
Human Breast ◽  
Mesenchymal Transition ◽  
Vitro Model

scholarly journals Correction: An In Vitro Model That Recapitulates the Epithelial to Mesenchymal Transition (EMT) in Human Breast Cancer

PLoS ONE ◽  
2011 ◽  
Vol 6 (4) ◽  
Author(s):  
Elad Katz ◽  
Sylvie Dubois-Marshall ◽  
Andrew H. Sims ◽  
Philippe Gautier ◽  
Helen Caldwell ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
In Vitro Model ◽  
Epithelial To Mesenchymal Transition ◽  
Human Breast ◽  
Mesenchymal Transition ◽  
Vitro Model

scholarly journals Correction: An In Vitro Model That Recapitulates the Epithelial to Mesenchymal Transition (EMT) in Human Breast Cancer

PLoS ONE ◽  
2011 ◽  
Vol 6 (4) ◽  
Author(s):  
Elad Katz ◽  
Sylvie Dubois-Marshall ◽  
Andrew H. Sims ◽  
Philippe Gautier ◽  
Helen Caldwell ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
In Vitro Model ◽  
Epithelial To Mesenchymal Transition ◽  
Human Breast ◽  
Mesenchymal Transition ◽  
Vitro Model

In Vitro Model Systems for the Study of Hormone-Dependent Human Breast Cancer

1977 ◽  
Vol 296 (3) ◽  
pp. 154-159 ◽  
Author(s):  
Howard L. Bleich ◽  
Emily S. Boro ◽  
Marc E. Lippman ◽  
C. Kent Osborne ◽  
Richard Knazek ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
In Vitro Model ◽  
Model Systems ◽  
Human Breast ◽  
Vitro Model

Antcin-A Modulates Epithelial-to-Mesenchymal Transition and Inhibits Migratory and Invasive Potentials of Human Breast Cancer Cells via p53-Mediated miR-200c Activation

Planta Medica ◽  
2019 ◽  
Vol 85 (09/10) ◽  
pp. 755-765 ◽  
Author(s):  
K. J. Senthil Kumar ◽  
M. Gokila Vani ◽  
Han-Wen Hsieh ◽  
Chin-Chung Lin ◽  
Sheng-Yang Wang
Keyword(s):  
Breast Cancer ◽  
Wound Healing ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Epithelial To Mesenchymal Transition ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Mesenchymal Transition

AbstractAntcin-A (ATA) is a steroid-like phytochemical isolated from the fruiting bodies of a precious edible mushroom Antrodia cinnamomea. We previously showed that ATA has strong anti-inflammatory and anti-tumor effects; however, other possible bioactivities of this unique compound remain unexplored. In the present study, we aimed to investigate the modulation of epithelial-to-mesenchymal transition (EMT), anti-migration, and anti-invasive potential of ATA against human breast cancer cells in vitro. Human breast cancer cell lines, MCF-7 and MDA-MB-231, were incubated with ATA for 24 h. Wound healing, trans-well invasion, western blot, q-PCR, F-actin staining, and immunofluorescence assays were performed. We found that treatment with ATA significantly blocked EMT processes, as evidenced by upregulation of epithelial markers (E-cadherin and occludin) and downregulation of mesenchymal markers (N-cadherin and vimentin) via suppression of their transcriptional repressor ZEB1. Next, we found that ATA could induce miR-200c, which is a known player of ZEB1 repression. Further investigations revealed that ATA-mediated induction of miR-200c is associated with transcriptional activation of p53, as confirmed by the fact that ATA failed to induce miR-200c or suppress ZEB1 activity in p53 inhibited cells. Further in vitro wound healing and trans-well invasion assays support that ATA could inhibit migratory and invasive potentials of breast cancer cells, and the effect was likely associated with induced phenotypic modulation. Taken together, the present study suggests that antcin-A could be a lead phyto-agent for the development of anti-metastatic drug for breast cancer treatment.

scholarly journals In vitro comparative models for canine and human breast cancers

2016 ◽  
Vol 89 (1) ◽  
pp. 38-49 ◽  
Author(s):  
Simona Visan ◽  
Ovidiu Balacescu ◽  
Ioana Berindan-Neagoe ◽  
Cornel Catoi
Keyword(s):  
Breast Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Breast Cancer ◽  
In Vitro Model ◽  
Early Stage ◽  
Cancer Cell Lines ◽  
Human Breast ◽  
Vitro Model

During the past four decades, an increased number of similarities between canine mammary tumors and human breast cancer have been reported: molecular, histological, morphological, clinical and epidemiological, which lead to comparative oncological studies. One of the most important goals in human and veterinary oncology is to discover potential molecular biomarkers that could detect breast cancer in an early stage and to develop new effective therapies. Recently, cancer cell lines have successfully been used as an in vitro model to study the biology of cancer, to investigate molecular pathways and to test the efficiency of anticancer drugs. Moreover, establishment of an experimental animal model for the study of human breast cancer will improve testing potential anti-cancer therapies and the discovery of effective therapeutic schemes suitable for human clinical trials.In this review, we collected data from previous studies that strengthen the value of canine mammary cancer cell lines as an in vitro model for the study of human breast cancer.

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