scholarly journals Theoretical perspectives on central chemosensitivity: CO2/H+-sensitive neurons in the locus coeruleus

2017 ◽  
Vol 13 (12) ◽  
pp. e1005853 ◽  
Author(s):  
Maria C. Quintero ◽  
Robert W. Putnam ◽  
Juan M. Cordovez
2010 ◽  
Vol 173 (3) ◽  
pp. 264-273 ◽  
Author(s):  
Luciane H. Gargaglioni ◽  
Lynn K. Hartzler ◽  
Robert W. Putnam

2006 ◽  
Vol 291 (4) ◽  
pp. R997-R1006 ◽  
Author(s):  
Carolina R. Noronha-de-Souza ◽  
Kênia C. Bícego ◽  
Gustavo Michel ◽  
Mogens L. Glass ◽  
Luiz G. S. Branco ◽  
...  

The locus coeruleus (LC) has been suggested as a CO2 chemoreceptor site in mammals. This nucleus is a mesencephalic structure of the amphibian brain and is probably homologous to the LC in mammals. There are no data available for the role of LC in the central chemoreception of amphibians. Thus the present study was designed to investigate whether LC of toads ( Bufo schneideri) is a CO2/H+ chemoreceptor site. Fos immunoreactivity was used to verify whether the nucleus is activated by hypercarbia (5% CO2 in air). In addition, we assessed the role of noradrenergic LC neurons on respiratory and cardiovascular responses to hypercarbia by using 6-hydroxydopamine lesion. To further explore the role of LC in central chemosensitivity, we examined the effects of microinjection of solutions with different pH values (7.2, 7.4, 7.6, 7.8, and 8.0) into the nucleus. Our main findings were that 1) a marked increase in c-fos-positive cells in the LC was induced after 3 h of breathing a hypercarbic gas mixture; 2) chemical lesions in the LC attenuated the increase of the ventilatory response to hypercarbia but did not affect ventilation under resting conditions; and 3) microinjection with acid solutions (pH = 7.2, 7.4, and 7.6) into the LC elicited an increased ventilation, indicating that the LC of toads participates in the central chemoreception.


2015 ◽  
Vol 26 (4) ◽  
pp. 207-221
Author(s):  
Wolfgang Mastnak

Abstract. Five overlapping eras or stages can be distinguished in the evolution of music therapy. The first one refers to the historical roots and ethnological sources that have influenced modern meta-theoretical perspectives and practices. The next stage marks the heterogeneous origins of modern music therapy in the 20th century that mirror psychological positions and novel clinical ideas about the healing power of music. The subsequent heyday of music therapeutic models and schools of thought yielded an enormous variety of concepts and methods such as Nordoff–Robbins music therapy, Orff music therapy, analytic music therapy, regulatory music therapy, guided imagery and music, sound work, etc. As music therapy gained in international importance, clinical applications required research on its therapeutic efficacy. According to standards of evidence-based medicine and with regard to clearly defined diagnoses, research on music therapeutic practice was the core of the fourth stage of evolution. The current stage is characterized by the emerging epistemological dissatisfaction with the paradigmatic reductionism of evidence-based medicine and by the strong will to discover the true healing nature of music. This trend has given birth to a wide spectrum of interdisciplinary hermeneutics for novel foundations of music therapy. Epigenetics, neuroplasticity, regulatory and chronobiological sciences, quantum physical philosophies, universal harmonies, spiritual and religious views, and the cultural anthropological phenomenon of esthetics and creativity have become guiding principles. This article should not be regarded as a historical treatise but rather as an attempt to identify theoretical landmarks in the evolution of modern music therapy and to elucidate the evolution of its spirit.


Author(s):  
Christoph Klimmt

This comment briefly examines the history of entertainment research in media psychology and welcomes the conceptual innovations in the contribution by Oliver and Bartsch (this issue). Theoretical perspectives for improving and expanding the “appreciation” concept in entertainment psychology are outlined. These refer to more systematic links of appreciation to the psychology of mixed emotions, to positive psychology, and to the psychology of death and dying – in particular, to terror management theory. In addition, methodological challenges are discussed that entertainment research faces when appreciation and the experience of “meaning for life” need to be addressed in empirical studies of media enjoyment.


2011 ◽  
Author(s):  
R. Bruce Thompson ◽  
Maryann Corsello ◽  
Samuel McReynolds ◽  
Bernice Conklin-Powers ◽  
Brittany Morley

Psychotherapy ◽  
1995 ◽  
Vol 32 (3) ◽  
pp. 505-506
Author(s):  
Dana E. O'Brien

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