scholarly journals Minimizing the number of optimizations for efficient community dynamic flux balance analysis

2020 ◽  
Vol 16 (9) ◽  
pp. e1007786 ◽  
Author(s):  
James D. Brunner ◽  
Nicholas Chia
2020 ◽  
Vol 117 (10) ◽  
pp. 3006-3017 ◽  
Author(s):  
Carolina Shene ◽  
Paris Paredes ◽  
Liset Flores ◽  
Allison Leyton ◽  
Juan A. Asenjo ◽  
...  

2012 ◽  
Vol 110 (3) ◽  
pp. 792-802 ◽  
Author(s):  
K. Höffner ◽  
S. M. Harwood ◽  
P. I. Barton

2013 ◽  
Vol 163 (2) ◽  
pp. 637-647 ◽  
Author(s):  
E. Grafahrend-Belau ◽  
A. Junker ◽  
A. Eschenroder ◽  
J. Muller ◽  
F. Schreiber ◽  
...  

2010 ◽  
Vol 12 (2) ◽  
pp. 150-160 ◽  
Author(s):  
Adam L. Meadows ◽  
Rahi Karnik ◽  
Harry Lam ◽  
Sean Forestell ◽  
Brad Snedecor

2014 ◽  
Vol 22 (03) ◽  
pp. 327-338 ◽  
Author(s):  
CAROL MILENA BARRETO-RODRIGUEZ ◽  
JESSICA PAOLA RAMIREZ-ANGULO ◽  
JORGE MARIO GOMEZ RAMIREZ ◽  
LUKE ACHENIE ◽  
HAROLD MOLINA-BULLA ◽  
...  

The advent of numerous technological platforms for genome sequencing has led to increasing understanding and construction of metabolic networks. A popular system engineering strategy is used to analyze microbial metabolic networks is flux balance analysis (FBA). In recent times, there has been a lot of interest in the study of the metabolic network dynamics when genes are overexpressed in the system. Herein, an optimization framework, which employs dynamic flux balance analysis (DFBA) is proposed for predicting ethanol concentration profiles in glycerol fermentations using Escherichia coli. In silico results were experimentally validated by overexpressing alcohol/acetaldehyde dehydrogenase adhE, pyruvate kinase pykF, pyruvate formate-lyase pflB and isoleucine-valine enzymes ilvC and llvL.


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