scholarly journals Treatment of Cutaneous Leishmaniasis Caused by Leishmania aethiopica: A Systematic Review

2016 ◽  
Vol 10 (3) ◽  
pp. e0004495 ◽  
Author(s):  
Johan van Griensven ◽  
Endalamaw Gadisa ◽  
Abraham Aseffa ◽  
Asrat Hailu ◽  
Abate Mulugeta Beshah ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cutaneous Leishmaniasis ◽  
Leishmania Aethiopica

Towards effective cutaneous leishmaniasis treatment with light-based technologies. A systematic review and meta-analysis of preclinical studies

2021 ◽  
pp. 112236
Author(s):  
Fernanda Viana Cabral ◽  
Tiago Henrique dos Santos Souza ◽  
Fábio Parra Sellera ◽  
Adriana Fontes ◽  
Martha Simões Ribeiro
Keyword(s):  
Systematic Review ◽  
Cutaneous Leishmaniasis ◽  
Meta Analysis ◽  
Preclinical Studies

scholarly journals An investigation of the effects of environmental and ecologic factors on cutaneous leishmaniasis in the old world: a systematic review study

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Abolfazl Mohammadbeigi ◽  
Salman Khazaei ◽  
Hamidreza Heidari ◽  
Azadeh Asgarian ◽  
Shahram Arsangjang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Environmental Factors ◽  
Land Cover ◽  
Cutaneous Leishmaniasis ◽  
Weather Condition ◽  
Weather Conditions ◽  
Eligibility Criteria ◽  
Screening Process ◽  
Old World ◽  
Review Study

AbstractObjectivesLeishmaniasis is a neglected and widespread parasitic disease that can lead to serious health problems. The current review study aimed to synthesize the relationship between ecologic and environmental factors (e.g., weather conditions, climatology, temperature and topology) and the incidence of cutaneous leishmaniasis (CL) in the Old World.ContentA systematic review was conducted based on English, and Persian articles published from 2015 to 2020 in PubMed/Medline, Science Direct, Web of Science and Google Scholar. Keywords used to search articles were leishmaniasis, environmental factors, weather condition, soil, temperature, land cover, ecologic* and topogr*. All articles were selected and assessed for eligibility according to the titles or abstracts. The quality screening process of articles was carried out by two independent authors. The selected articles were checked according to the inclusion and exclusion criteria.Summary and outlookA total of 827 relevant records in 2015–2020 were searched and after evaluating the articles, 23 articles met the eligibility criteria; finally, 14 full-text articles were included in the systematic review. Two different categories of ecologic/environmental factors (weather conditions, temperature, rainfall/precipitation and humidity) and land characteristics (land cover, slope, elevation and altitude, earthquake and cattle sheds) were the most important factors associated with CL incidence.ConclusionsTemperature and rainfall play an important role in the seasonal cycle of CL as many CL cases occurred in arid and semiarid areas in the Old World. Moreover, given the findings of this study regarding the effect of weather conditions on CL, it can be concluded that designing an early warning system is necessary to predict the incidence of CL based on different weather conditions.

scholarly journals Cutaneous Leishmaniasis Due to Leishmania aethiopica

2018 ◽  
Vol 6 ◽  
pp. 69-81 ◽  
Author(s):  
Saskia van Henten ◽  
Wim Adriaensen ◽  
Helina Fikre ◽  
Hannah Akuffo ◽  
Ermias Diro ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Leishmania Aethiopica

scholarly journals Is there an association between cutaneous leishmaniasis and skin cancer? A systematic review

2019 ◽  
Vol 4 ◽  
pp. 110
Author(s):  
Rodrigo M. Carrillo-Larco ◽  
J. Gonzalo Acevedo-Rodriguez ◽  
Carlos Altez-Fernandez ◽  
Karol Ortiz-Acha ◽  
Cesar Ugarte-Gil
Keyword(s):  
Systematic Review ◽  
Skin Cancer ◽  
Cutaneous Leishmaniasis ◽  
Observational Studies ◽  
Communicable Disease ◽  
Case Reports ◽  
Communicable Diseases ◽  
Neglected Diseases ◽  
Non Communicable Diseases ◽  
Co Morbidity

Background: Cutaneous leishmaniasis is a prevalent communicable disease in low- and middle-income countries, where non-communicable diseases like skin cancer are on the rise. However, the study of multi-morbidity or co-morbidity between communicable and non-communicable diseases is limited, and even null for some tropical or neglected diseases. Nevertheless, looking at these conditions together instead of as isolated entities in places where these illnesses exist, could show new prevention and treatment paths. We aimed to summarize and critically appraise the epidemiological evidence on the association between cutaneous leishmaniasis and skin cancer. Methods: Following the PRISMA guidelines, we conducted a systematic review using five search engines (Embase, Medline, Global Health, Scopus and Web of Science). We sought observational studies in which the outcome was skin cancer whilst the exposure was cutaneous leishmaniasis; these conditions should have had laboratory or pathology confirmation. Results: No epidemiological investigations have studied the association between cutaneous leishmaniasis and skin cancer. Most of the evidence about the association of interest is still based on case reports and other clinical observations rather than strong epidemiological observational studies. Conclusions: Research is much needed to verify the repeatedly clinical observation that cutaneous leishmaniasis may be a risk factor for skin cancer. This evidence could inform and guide early diagnosis or prevention of skin cancer in survivors of cutaneous leishmaniasis or where cutaneous leishmaniasis is still highly prevalent. Registration: PROSPERO ID CRD42018111230; registered on 16/10/18.

Economic evaluations in cutaneous leishmaniasis: a systematic review of literature 1980-2015

2017 ◽  
pp. 52-70
Author(s):  
Jaiberth Antonio Cardona-Arias ◽  
◽  
Diana Astrid Patiño-Martínez ◽  
Liliana López Carvajal ◽  
◽  
...  
Keyword(s):  
Systematic Review ◽  
Cutaneous Leishmaniasis ◽  
Economic Evaluations ◽  
Review Of Literature

scholarly journals Miltefosine for the treatment of cutaneous leishmaniasis—A pilot study from Ethiopia

2021 ◽  
Vol 15 (5) ◽  
pp. e0009460
Author(s):  
Saskia van Henten ◽  
Annisa Befekadu Tesfaye ◽  
Seid Getahun Abdela ◽  
Feleke Tilahun ◽  
Helina Fikre ◽  
...  
Keyword(s):  
Side Effects ◽  
Cutaneous Leishmaniasis ◽  
Systemic Treatment ◽  
Initial Response ◽  
Tablet Form ◽  
Leishmania Aethiopica ◽  
Mucosal Involvement ◽  
Observational Cohort ◽  
Good Improvement ◽  
Favorable Side Effect Profile

Background Cutaneous leishmaniasis (CL) in Ethiopia, caused by Leishmania aethiopica, is often severe and hard to treat compared to CL caused by other species elsewhere. Miltefosine is the only oral anti-leishmanial drug, with a favorable side-effect profile compared to routinely available sodium stibogluconate (SSG), but evidence about its use for L. aethiopica is lacking. Methodology and principal findings In an observational cohort study, treatment outcomes, safety and adherence among CL patients who required systemic treatment and received miltefosine for 28 days in Boru Meda Hospital and University of Gondar Hospital were studied. Patient cure was defined as 100% flattening for non-ulcerated lesions and 100% flattening and 100% re-epithelization for ulcerated lesions. Outcomes were documented for day 28, 90 and 180, both per site, and pooled, adjusting for site as a fixed effect with effect coding. Among 94 included patients (32 in Gondar, 62 in Boru Meda), median lesion duration was 12 months, median size six cm, and mucosal involvement (46.8%) and diffuse (30.9%) lesions were common. Adherence to miltefosine was good, and side-effects were tolerable. Initial outcomes at day 28 were promising, with 68.8% and 94.0% of patients having good improvement or cure in Gondar and Boru Meda respectively. In Boru Meda, outcomes were good with 72.7% and 72.9% cure at day 90 and day 180 respectively. In Gondar, results were less promising, with only 12.5% and 26.7% cure at day 90 and day 180, although confidence intervals were wide. In pooled estimates, 48.7% of patients reached cure at day 180, and 32.3% relapsed. Outcomes were better in Boru Meda Hospital, for smaller lesions and for mucosal lesions. Conclusions/Significance Based on miltefosine’s good initial response, tolerable side-effects, tablet-form, we propose to include miltefosine for future clinical trials using extended treatment schedules, combination therapy, or targeting specific subgroups. Trial registration ClinicalTrials.gov NCT04004754.

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