scholarly journals Early Life Disease Programming during the Preconception and Prenatal Period: Making the Link between Stressful Life Events and Type-1 Diabetes

PLoS ONE ◽  
2010 ◽  
Vol 5 (7) ◽  
pp. e11523 ◽  
Author(s):  
Jasveer Virk ◽  
Jiong Li ◽  
Mogens Vestergaard ◽  
Carsten Obel ◽  
Michael Lu ◽  
...  
2018 ◽  
Vol 50 (6) ◽  
pp. 676-686 ◽  
Author(s):  
Kevin L. Joiner ◽  
Margaret L. Holland ◽  
Margaret Grey

2021 ◽  
Vol 12 ◽  
Author(s):  
Anja Turin ◽  
Klemen Dovč ◽  
Simona Klemenčič ◽  
Nataša Bratina ◽  
Tadej Battelino ◽  
...  

Background/Objective: Type 1 diabetes (T1D) is among the most common chronic diseases in children/adolescents, and the incidence continues to rise worldwide. Different environmental factors have been evaluated in the etiology. In the present study, we investigated the role of attachment examining whether insecure attachment to carers or carers' own attachment insecurity was related to a higher risk of T1D in children.Methods: We included 101 children with T1D (mean age 11.8 years), 106 healthy controls (11.6 years), and one of their carers. We assessed children's attachment using the Child Attachment Interview and carers' attachment using the Relationship Structures Questionnaire. We constructed binary multinomial logistic regression models using attachment to mothers, carers' attachment representations, and stressful life-events as T1D predictors.Results: Higher carer attachment anxiety was associated with the child's T1D diagnosis (p < 0.05; R2 = 0.0613) while security of attachment to mothers showed no significant association. When mothers' education was included in the model, both attachment anxiety in higher educated mothers and stressful life events showed a significant association with the child's T1D (p < 0.001; R2 = 0.293).Conclusions: Our findings suggest that higher attachment-related anxiety in carers with high education and stressful life events are associated with T1D in children.


1987 ◽  
Vol 17 (4) ◽  
pp. 299-308 ◽  
Author(s):  
John A. Humphrey ◽  
Stuart Palmer

Stressful life events experienced by a 50 percent random sample of criminal homicide offenders (270) and a 30 percent random sample of nonviolent felonious property offenders (194) incarcerated in North Carolina over a two-year period are analyzed. Dohrenwend et al. Psychiatric Epidemiological Research Interview (PERI) was expanded to include occurrences in childhood and was used to assess the extent of stressful life events. These events were divided into loss and nonloss items; and whether the event occurred in the early life of the offender (past event) or in closer proximity to the crime (recent event). Murderers were divided into primary offenders, those whose victims were family members or close friends; and nonprimary offenders, those who killed strangers or mere acquaintances. The findings show that criminal homicide offenders experienced stressful life events in greater number and more consistently than did nonviolent felons. Further, primary homicide offenders tended to suffer more stressful life events involving loss, although nonprimary offenders experienced more nonloss stress events.


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