scholarly journals Distinct Cerebrospinal Fluid Proteomes Differentiate Post-Treatment Lyme Disease from Chronic Fatigue Syndrome

PLoS ONE ◽  
2011 ◽  
Vol 6 (2) ◽  
pp. e17287 ◽  
Author(s):  
Steven E. Schutzer ◽  
Thomas E. Angel ◽  
Tao Liu ◽  
Athena A. Schepmoes ◽  
Therese R. Clauss ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Chronic Fatigue Syndrome ◽  
Lyme Disease ◽  
Chronic Fatigue ◽  
Post Treatment ◽  
Fatigue Syndrome

scholarly journals Heterodox and Orthodox Discourses in the Case of Lyme Disease: A Synthesis of Arguments

2019 ◽  
Vol 29 (11) ◽  
pp. 1661-1673
Author(s):  
Kate Hinds ◽  
Katy Sutcliffe
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Lyme Disease ◽  
Critical Discourse Analysis ◽  
Chronic Fatigue ◽  
Critical Discourse ◽  
Fatigue Syndrome ◽  
Chronic Lyme Disease ◽  
Medically Unexplained ◽  
Patient Groups ◽  
Insight Into

In this article, we examine the arguments made by authors of published academic articles concerning the debates surrounding chronic Lyme disease (CLD). CLD is an example of a contested condition and shares problems of legitimacy with other medically unexplained conditions such as chronic fatigue syndrome. We use a critical discourse analysis (CDA) approach to understand the arguments of the authors to establish the legitimacy, or not, of a CLD diagnosis. This enabled us to make sense of the nature of the stalemate between patient groups and advocates of the medical establishment, as performed by authors of academic articles. In this article, we bring together the arguments to explain the polemical debate and to support accounts that avoid the impasse to give us greater insight into the experience of chronic illness.

Cytokine network analysis of cerebrospinal fluid in myalgic encephalomyelitis/chronic fatigue syndrome

2015 ◽  
Vol 21 (2) ◽  
pp. 261-269 ◽  
Author(s):  
M Hornig ◽  
G Gottschalk ◽  
D L Peterson ◽  
K K Knox ◽  
A F Schultz ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Network Analysis ◽  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Cytokine Network ◽  
Fatigue Syndrome

Characterising DSCATT: A case series of Australian patients with debilitating symptom complexes attributed to ticks

2021 ◽  
pp. 000486742110437
Author(s):  
Jesse Schnall ◽  
Georgina Oliver ◽  
Sabine Braat ◽  
Richard Macdonell ◽  
Katherine B Gibney ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Lyme Disease ◽  
Case Series ◽  
Disease Process ◽  
Chronic Fatigue ◽  
Retrospective Case ◽  
Medical Diagnoses ◽  
Fatigue Syndrome ◽  
First Case ◽  
Medically Unexplained

Objectives(s): To characterise the clinical profile, aetiology and treatment responsiveness of ‘Australian Lyme’, or Debilitating Symptom Complexes Attributed to Ticks. Methods: Single-centre retrospective case analysis of patients referred to the Infectious Diseases Unit at Austin Health – a tertiary health service in Heidelberg, Australia – between 2014 and 2020 for investigation and treatment of suspected Debilitating Symptom Complexes Attributed to Ticks. Patients were included if they had debilitating symptoms suggested by either themselves or the referring clinician as being attributed to ticks. Results: Twenty-nine Debilitating Symptom Complexes Attributed to Ticks cases were included in the analysis. Other than Lyme disease (83%), the most common prior medical diagnoses were Epstein–Barr virus (38%), chronic fatigue syndrome (28%) and fibromyalgia (24%). Prior histories of anxiety (48%) and depression (41%) were common. The most frequently reported symptoms included fatigue (83%), headache (72%) and arthralgia (69%). National Association of Testing Authorities/Royal College of Pathologists of Australasia–accredited serology was not diagnostic of acute infective causes, including Lyme disease, in any patient. Of 25 cases with available data, 23 (92%) had previously been prescribed antimicrobials, with 53% reporting benefit from them. The most common diagnoses made by our hospital were chronic fatigue syndrome (31%), migraines (28%) and fibromyalgia (21%). Only one patient’s symptoms were not accounted for by other diagnoses. Conclusion: This is the first case series of patients with Debilitating Symptom Complexes Attributed to Ticks. They had high rates of other medically unexplained syndromes, and no evidence of acute Lyme disease, or any common organic disease process. Debilitating Symptom Complexes Attributed to Ticks remains medically unexplained, and may therefore be due to an as yet unidentified cause, or may be considered a medically unexplained syndrome similar to conditions such as chronic fatigue syndrome.

scholarly journals Cytokines in the Cerebrospinal Fluids of Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
D. Peterson ◽  
E. W. Brenu ◽  
G. Gottschalk ◽  
S. Ramos ◽  
T. Nguyen ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Chronic Fatigue Syndrome ◽  
Preliminary Investigation ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Healthy Controls ◽  
Gm Csf ◽  
Fatigue Syndrome ◽  
Human Cytokine

Objectives. Previous research has provided evidence for dysregulation in peripheral cytokines in patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). To date only one study has examined cytokines in cerebrospinal fluid (CSF) samples of CFS/ME patients. The purpose of this pilot study was to examine the role of cytokines in CSF of CFS/ME patients.Methods. CSF was collected from 18 CFS/ME patients and 5 healthy controls. The CSF samples were examined for the expression of 27 cytokines (interleukin- (IL-) 1β, IL-1ra, IL-2, IL-4, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12p70, IL-13, IL-15, IL-17, basic FGF, eotaxin, G-CSF, GM-CSF, IFN-γ, IP-10, MCP-1 (MCAF), MIP-1α, MIP-1β, PDGF-BB, RANTES, TNF-α, and VEGF) using the Bio-Plex Human Cytokine 27-plex Assay.Results. Of the 27 cytokines examined, only IL-10 was significantly reduced in the CFS/ME patients in comparison to the controls.Conclusions. This preliminary investigation suggests that perturbations in inflammatory cytokines in the CSF of CFS/ME patients may contribute to the neurological discrepancies observed in CFS/ME.

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