scholarly journals Metabolic Syndrome, Alcohol Consumption and Genetic Factors Are Associated with Serum Uric Acid Concentration

PLoS ONE ◽  
2014 ◽  
Vol 9 (5) ◽  
pp. e97646 ◽  
Author(s):  
Blanka Stibůrková ◽  
Markéta Pavlíková ◽  
Jitka Sokolová ◽  
Viktor Kožich
Keyword(s):  
Metabolic Syndrome ◽  
Uric Acid ◽  
Alcohol Consumption ◽  
Serum Uric Acid ◽  
Acid Concentration ◽  
Genetic Factors ◽  
Uric Acid Concentration ◽  
Serum Uric Acid Concentration

scholarly journals Losartan and Eprosartan Induce a Similar Effect on the Acute Rise in Serum Uric Acid Concentration after an Oral Fructose Load in Patients with Metabolic Syndrome

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Anna Masajtis-Zagajewska ◽  
Jacek Majer ◽  
Michał Nowicki
Keyword(s):  
Metabolic Syndrome ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Acid Concentration ◽  
Antihypertensive Drugs ◽  
Uric Acid Concentration ◽  
Urine Excretion ◽  
At1 Receptor Antagonists ◽  
Serum Uric Acid Concentration ◽  
Neutral Effect

Introduction. Excessive intake of fructose increases serum uric acid concentration. Hyperuricemia induces a negative effect on atherosclerosis and inflammation. Hyperuricemia is common in patients with arterial hypertension. Several antihypertensive drugs including diuretics increase serum uric acid concentration. In contrast, the angiotensin II receptor antagonist (ARB) losartan was found to lower serum uric acid though it may increase renal excretion while other ARBs showed mostly a neutral effect. In this study, effects of two AT1 receptor antagonists losartan and eprosartan on serum uric acid changes induced by oral fructose load were directly compared. Methods. The randomized, crossover, head-to-head comparative study comprised 16 ambulatory patients (mean age 64.5 ± 9.8 years). The patients fulfilled AHA/NHLBI 2005 criteria of metabolic syndrome. A daily single morning dose of each study drug (50 mg of losartan or 600 mg of eprosartan) was given during two 3-month periods in a random order separated by 2-week washout time. The oral fructose tolerance test (OFTT) was performed at baseline and after each two 3-onth treatment periods. Before and during OFTT, urine excretion of uric acid and creatinine was assessed in the first morning portion of urine. Blood samples for the measurement of serum uric acid and lipids were taken at baseline and 30, 60, and 120 minutes after oral intake of 75 g of fructose. Results. After 3-month treatment with eprosartan and losartan, both systolic and diastolic blood pressure decreased significantly and to a similar extent. After the treatment, serum uric acid and its baseline and postfructose urine excretion were unchanged. No significant changes of plasma lipids before and after OFTT were observed throughout the study. Conclusions. The study showed that in patients with hypertension and metabolic syndrome, both losartan and eprosartan have a neutral effect on fasting and postfructose load serum uric acid concentration and its urinary excretion. This trial is registered with NCT04954560.

scholarly journals Relationship Between Serum Uric Acid Concentration and Insulin Resistance and Metabolic Syndrome

2005 ◽  
Vol 69 (8) ◽  
pp. 928-933 ◽  
Author(s):  
Tae Woo Yoo ◽  
Ki Chul Sung ◽  
Hun Sub Shin ◽  
Byung Jin Kim ◽  
Bum Soo Kim ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Acid Concentration ◽  
Uric Acid Concentration ◽  
Serum Uric Acid Concentration

Low serum uric acid concentration augments insulin effects on the prevalence of metabolic syndrome

2018 ◽  
Vol 12 (3) ◽  
pp. 325-331 ◽  
Author(s):  
Leonardo M. Porchia ◽  
M. Elba Gonzalez-Mejia ◽  
Enrique Torres-Rasgado ◽  
Guadalupe Ruiz-Vivanco ◽  
Ricardo Pérez-Fuentes
Keyword(s):  
Metabolic Syndrome ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Acid Concentration ◽  
Uric Acid Concentration ◽  
Serum Uric Acid Concentration ◽  
Low Serum

scholarly journals The prevalence of hyperuricemia and its associated risk factors in patients presenting with joint pain in Karachi

2020 ◽  
Vol 6 (6) ◽  
pp. 1151
Author(s):  
Muhammad Muzzammil ◽  
Abdul Qadir ◽  
Ayesha Mughal ◽  
Jahazeb Effendi ◽  
Muhammad Saeed Minhas ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Uric Acid ◽  
Alcohol Consumption ◽  
Renal Disease ◽  
Serum Creatinine ◽  
Serum Uric Acid ◽  
Joint Pain ◽  
Genetic Factors ◽  
Chronic Renal Disease ◽  
Uric Acid Concentration

<p class="abstract"><strong>Background:</strong> To determine the prevalence and association of hyperuricemia with genetic factors, dietary and alcohol consumption, metabolic syndrome, diuretic use and chronic renal disease in patients presenting with joint pain in the outpatient department (OPD) at a tertiary care hospital of Karachi, Pakistan and to establish a significant correlation between concentration of serum creatinine and triglyceride with uric acid concentration statistically.</p><p class="abstract"><strong>Methods:</strong> This study was conducted on 2200 patients. The data included age, gender, occupation, genetic factors (family history), dietary and alcohol consumption, metabolic syndrome, hypertension, obesity, diuretic use and chronic renal disease. Serum uric acid concentration of 2.4-6.0 mg/dl (female) and 3.4-7.0 mg/dl (male) labelled as normal values. All participants’ serum uric acid concentration compared with serum creatinine and triglyceride concentration.<strong></strong></p><p class="abstract"><strong>Results:</strong> Overall prevalence of 30.1% (662 patients) hyperuricemia in patients presenting with joint pain. Majority of the patients belonged to age group 30-34 and highest average uric acid value (7.7±2.01) was found to be in the age group of 65 and above. Hyperuricemia was related to increased age (56.25%), genetic factors 159 (24.01%), dietary 370 (55.89%) and alcohol consumption 33 (4.98%), metabolic syndrome (hypertension 146 (22.05%), obesity 121 (18.27%), diuretic use 215 (32.47%) and chronic renal disease 53 (8.00%). On laboratory investigations, hyperuricemia was directly related to serum creatinine and triglyceride.</p><p class="abstract"><strong>Conclusions:</strong> This study emphasized the high prevalence of hyperuricemia in patients presenting with joint pain and it is directly proportional to the age. Increased serum uric acid levels with increasing age might be secondary to impaired renal function, use of diuretics, and hypertension as commonly seen among elderly patients. Early diagnosis, management of risk factors and treatment will prevent adverse effects on health.</p><p class="abstract"> </p>

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