scholarly journals Sequencing and G-Quadruplex Folding of the Canine Proto-Oncogene KIT Promoter Region: Might Dog Be Used as a Model for Human Disease?

PLoS ONE ◽  
2014 ◽  
Vol 9 (8) ◽  
pp. e103876 ◽  
Author(s):  
Silvia Da Ros ◽  
Eleonora Zorzan ◽  
Mery Giantin ◽  
Lara Zorro Shahidian ◽  
Manlio Palumbo ◽  
...  
Keyword(s):  
Human Disease ◽  
Promoter Region ◽  
G Quadruplex

scholarly journals Control of bacterial nitrate assimilation by stabilization of G-quadruplex DNA

2016 ◽  
Vol 52 (92) ◽  
pp. 13511-13514 ◽  
Author(s):  
Zoë A. E. Waller ◽  
Benjamin J. Pinchbeck ◽  
Bhovina Seewoodharry Buguth ◽  
Timothy G. Meadows ◽  
David J. Richardson ◽  
...  
Keyword(s):  
Promoter Region ◽  
Paracoccus Denitrificans ◽  
Nitrate Assimilation ◽  
Quadruplex Dna ◽  
G Quadruplex ◽  
Specific Control

Ligand-specific control of nitrate assimilation inParacoccus denitrificansby stabilization of DNA G-quadruplex in the promoter region ofnas.

Relative stability of G-quadruplex structures: Interactions between the human Bcl2 promoter region and derivatives of carbazole and diphenylamine

Biopolymers ◽  
2014 ◽  
Vol 101 (10) ◽  
pp. 1038-1050 ◽  
Author(s):  
Sheh-Yi Sheu ◽  
Chao-Hsien Huang ◽  
Jia-Kai Zhou ◽  
Dah-Yen Yang
Keyword(s):  
Relative Stability ◽  
Promoter Region ◽  
G Quadruplex ◽  
Derivatives Of

scholarly journals Effect of Ionic Strength on Porphyrin Drugs Interaction with Quadruplex DNA Formed by the Promoter Region of C-myc and Bcl2 Oncogenes

2010 ◽  
Vol 2010 ◽  
pp. 1-9 ◽  
Author(s):  
Narayana Nagesh ◽  
Varun K. Sharma ◽  
A. Ganesh Kumar ◽  
Edwin A. Lewis
Keyword(s):  
Ionic Strength ◽  
Fluorescence Spectroscopy ◽  
Drug Interactions ◽  
Promoter Region ◽  
Promoter Regions ◽  
Quadruplex Dna ◽  
Quadruplex Structure ◽  
G Quadruplex ◽  
Drugs Interaction ◽  
Dna Complex

C-myc and Bcl2 are well characterized oncogenes that are capable of forming G-quadruplex structures. Promoter regions of C-myc and Bcl2 forming G-quadruplex structures are chemically synthesized and G-quadruplex structure is formed in presence of 100 mM potassium ion. Three different porphyrin drugs, namely TMPyP2, TMPyP3, and TMPyP4 are allowed to interact with quadruplex DNA complex and the site and nature of interaction are studied. Drug interactions with quadruplex DNA were carried out in different potassium ionic strengths using fluorescence spectroscopy. It is found that fluorescence hypochromicity decreases with an increase in ionic strength in the case of TMPyP4, TMPyP3, and TMPyP2. Fluorescence titration studies and Job plots indicate that four molecules of TMPyP4, two molecules of TMPyP3 and TMPyP2 are interacting with one molecule of quadruplex DNA.

scholarly journals A short peptide that preferentially binds c-MYC G-quadruplex DNA

2020 ◽  
Vol 56 (63) ◽  
pp. 8940-8943 ◽  
Author(s):  
Aisling Minard ◽  
Danielle Morgan ◽  
Federica Raguseo ◽  
Anna Di Porzio ◽  
Denise Liano ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Human Genome ◽  
Promoter Region ◽  
Secondary Structures ◽  
Quadruplex Dna ◽  
Short Peptide ◽  
G Quadruplex

G-quadruplexes are nucleic-acids secondary structures that are highly abundant in the human genome. In this work,we identified a short-peptide that displays selectivity for the G-quadruplex formed in the promoter region of the oncogene c-MYC.

scholarly journals Use of a Designed Peptide Library to Screen for Binders to a Particular DNA G-Quadruplex Sequence

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Keita Kobayashi ◽  
Noriko Matsui ◽  
Kenji Usui
Keyword(s):  
Clustering Analysis ◽  
Promoter Region ◽  
Peptide Library ◽  
Short Peptides ◽  
Hierarchical Clustering Analysis ◽  
Quadruplex Structure ◽  
Naturally Occurring ◽  
Binding Data ◽  
G Quadruplex ◽  
Screening Guideline

We demonstrated a method to screen for binders to a particular G-quadruplex sequence using easily designed short peptides consisting of naturally occurring amino acids and mining of binding data using statistical methods such as hierarchical clustering analysis (HCA). Despite the small size of the library used in this study, candidates of specific binders were identified. In addition, a selected peptide stabilized the G-quadruplex structure of a DNA oligonucleotide derived from the promoter region of the protooncogene c-MYC. This study illustrates how a peptide library can be designed and presents a screening guideline for construction of G-quadruplex binders. Such G-quadruplex peptide binders could be functionally modified to enable switching, cellular penetration, and organelle-targeting for cell and tissue engineering.

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