First-In-Human, Double-Blind, Placebo-Controlled, Randomized, Dose-Escalation Study of BG00010, a Glial Cell Line-Derived Neurotrophic Factor Family Member, in Subjects with Unilateral Sciatica

Paul E. Rolan; Gilmore O’Neill; Eve Versage; Jitesh Rana; Yongqiang Tang; Gerald Galluppi; Ernesto Aycardi

doi:10.1371/journal.pone.0125034

First-In-Human, Double-Blind, Placebo-Controlled, Randomized, Dose-Escalation Study of BG00010, a Glial Cell Line-Derived Neurotrophic Factor Family Member, in Subjects with Unilateral Sciatica

PLoS ONE ◽

10.1371/journal.pone.0125034 ◽

2015 ◽

Vol 10 (5) ◽

pp. e0125034 ◽

Cited By ~ 16

Author(s):

Paul E. Rolan ◽

Gilmore O’Neill ◽

Eve Versage ◽

Jitesh Rana ◽

Yongqiang Tang ◽

...

Keyword(s):

Family Member ◽

Cell Line ◽

Glial Cell ◽

Dose Escalation ◽

Neurotrophic Factor ◽

Dose Escalation Study ◽

Double Blind ◽

Double Blind Placebo

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Faculty Opinions recommendation of A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.13409136.14780164 ◽

2011 ◽

Author(s):

John Laffey ◽

Mairead Hayes

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Stem Cells ◽

Mesenchymal Stem Cells ◽

Dose Escalation ◽

Human Mesenchymal Stem Cells ◽

Dose Escalation Study ◽

Double Blind ◽

Double Blind Placebo ◽

Adult Human

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A Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation Study of Intravenous Adult Human Mesenchymal Stem Cells (Prochymal) After Acute Myocardial Infarction

Yearbook of Cardiology ◽

10.1016/s0145-4145(10)79814-2 ◽

2010 ◽

Vol 2010 ◽

pp. 389-391 ◽

Cited By ~ 3

Author(s):

B.J. Gersh

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Stem Cells ◽

Mesenchymal Stem Cells ◽

Dose Escalation ◽

Human Mesenchymal Stem Cells ◽

Dose Escalation Study ◽

Double Blind ◽

Double Blind Placebo ◽

Adult Human

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Safety and Pharmacokinetics of the Oral TYK2 Inhibitor PF‐06826647: A Phase I, Randomized, Double‐Blind, Placebo‐Controlled, Dose‐Escalation Study

Clinical and Translational Science ◽

10.1111/cts.12929 ◽

2020 ◽

Cited By ~ 1

Author(s):

Ravi Shankar P. Singh ◽

Vivek Pradhan ◽

Erika S. Roberts ◽

Matthew Scaramozza ◽

Elizabeth Kieras ◽

...

Keyword(s):

Phase I ◽

Dose Escalation ◽

Dose Escalation Study ◽

Double Blind ◽

Double Blind Placebo

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Safety and Immunogenicity of a Plant-Produced Recombinant Hemagglutinin-Based Influenza Vaccine (HAI-05) Derived from A/Indonesia/05/2005 (H5N1) Influenza Virus: A Phase 1 Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation Study in Healthy Adults

Viruses ◽

10.3390/v4113227 ◽

2012 ◽

Vol 4 (11) ◽

pp. 3227-3244 ◽

Cited By ~ 48

Author(s):

Jessica Chichester ◽

R. Jones ◽

Brian Green ◽

Mark Stow ◽

Fudu Miao ◽

...

Keyword(s):

Influenza Virus ◽

Influenza Vaccine ◽

Dose Escalation ◽

Phase 1 ◽

H5n1 Influenza Virus ◽

Dose Escalation Study ◽

Double Blind ◽

Double Blind Placebo ◽

H5n1 Influenza ◽

Recombinant Hemagglutinin

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Erratum: A Phase 1B, randomized, double blind, placebo controlled, multiple-dose escalation study of NSI-189 phosphate, a neurogenic compound, in depressed patients

Molecular Psychiatry ◽

10.1038/mp.2016.140 ◽

2016 ◽

Vol 21 (10) ◽

pp. 1483-1484 ◽

Cited By ~ 5

Author(s):

M Fava ◽

K Johe ◽

L Ereshefsky ◽

L G Gertsik ◽

B A English ◽

...

Keyword(s):

Dose Escalation ◽

Multiple Dose ◽

Dose Escalation Study ◽

Double Blind ◽

Double Blind Placebo ◽

Depressed Patients ◽

Phase 1B

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A randomized, double-blind, placebo-controlled, dose-escalation study of the safety and efficacy of INCB039110, an oral janus kinase 1 inhibitor, in patients with stable, chronic plaque psoriasis

Journal of Dermatological Treatment ◽

10.3109/09546634.2015.1115819 ◽

2016 ◽

Vol 27 (4) ◽

pp. 332-338 ◽

Cited By ~ 32

Author(s):

Robert Bissonnette ◽

Monica Luchi ◽

Rosanne Fidelus-Gort ◽

Shawnta Jackson ◽

Haifeng Zhang ◽

...

Keyword(s):

Dose Escalation ◽

Plaque Psoriasis ◽

Janus Kinase ◽

Chronic Plaque Psoriasis ◽

Dose Escalation Study ◽

Double Blind ◽

Safety And Efficacy ◽

Double Blind Placebo ◽

Janus Kinase 1

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Artemin, a Glial Cell Line-Derived Neurotrophic Factor Family Member, Induces TRPM8-Dependent Cold Pain

Journal of Neuroscience ◽

10.1523/jneurosci.5765-12.2013 ◽

2013 ◽

Vol 33 (30) ◽

pp. 12543-12552 ◽

Cited By ~ 59

Author(s):

E. K. Lippoldt ◽

R. R. Elmes ◽

D. D. McCoy ◽

W. M. Knowlton ◽

D. D. McKemy

Keyword(s):

Family Member ◽

Cell Line ◽

Glial Cell ◽

Neurotrophic Factor ◽

Cold Pain

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Safety and pharmacokinetics of PF-04360365 following a single-dose intravenous infusion in Japanese subjects with mild-to-moderate Alzheimerâs disease: a multicenter, randomized, double-blind, placebo-controlled, dose-escalation study

International Journal of Clinical Pharmacology and Therapeutics ◽

10.5414/cp201816 ◽

2013 ◽

Vol 51 (12) ◽

pp. 911-923 ◽

Cited By ~ 14

Author(s):

Izuru Miyoshi ◽

Yoko Fujimoto ◽

Masahito Yamada ◽

Sadahiro Abe ◽

Qinying Zhao ◽

...

Keyword(s):

Single Dose ◽

Dose Escalation ◽

Intravenous Infusion ◽

Dose Escalation Study ◽

Double Blind ◽

Double Blind Placebo ◽

Japanese Subjects

Download Full-text

Epicutaneous allergen-specific immunotherapy ameliorates grass pollen–induced rhinoconjunctivitis: A double-blind, placebo-controlled dose escalation study

Journal of Allergy and Clinical Immunology ◽

10.1016/j.jaci.2011.08.036 ◽

2012 ◽

Vol 129 (1) ◽

pp. 128-135 ◽

Cited By ~ 108

Author(s):

Gabriela Senti ◽

Seraina von Moos ◽

Fabian Tay ◽

Nicole Graf ◽

Theodor Sonderegger ◽

...

Keyword(s):

Dose Escalation ◽

Grass Pollen ◽

Specific Immunotherapy ◽

Dose Escalation Study ◽

Double Blind ◽

Allergen Specific Immunotherapy ◽

Double Blind Placebo

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Effect of the Adenosine A1 Receptor Antagonist, KW-3902, on Diuresis and Renal Function in Patients with Acute Decompensated Heart Failure Refractory to Maximum Doses of Conventional Diuretics: A Randomized, Double-Blind, Placebo Controlled, Dose Escalation Study

Journal of Cardiac Failure ◽

10.1016/j.cardfail.2006.06.281 ◽

2006 ◽

Vol 12 (6) ◽

pp. S82-S83 ◽

Cited By ~ 2

Author(s):

Michael M. Givertz ◽

Michael Tansey ◽

Leeanne L. Pearson ◽

Tara K. Fields ◽

Howard C. Dittrich

Keyword(s):

Heart Failure ◽

Renal Function ◽

Dose Escalation ◽

Acute Decompensated Heart Failure ◽

Decompensated Heart Failure ◽

Dose Escalation Study ◽

Double Blind ◽

Double Blind Placebo ◽

Adenosine A1 ◽

A1 Receptor

Download Full-text

First-In-Human, Double-Blind, Placebo-Controlled, Randomized, Dose-Escalation Study of BG00010, a Glial Cell Line-Derived Neurotrophic Factor Family Member, in Subjects with Unilateral Sciatica

Faculty Opinions recommendation of A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction.

A Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation Study of Intravenous Adult Human Mesenchymal Stem Cells (Prochymal) After Acute Myocardial Infarction

Safety and Pharmacokinetics of the Oral TYK2 Inhibitor PF‐06826647: A Phase I, Randomized, Double‐Blind, Placebo‐Controlled, Dose‐Escalation Study

Safety and Immunogenicity of a Plant-Produced Recombinant Hemagglutinin-Based Influenza Vaccine (HAI-05) Derived from A/Indonesia/05/2005 (H5N1) Influenza Virus: A Phase 1 Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation Study in Healthy Adults

Erratum: A Phase 1B, randomized, double blind, placebo controlled, multiple-dose escalation study of NSI-189 phosphate, a neurogenic compound, in depressed patients

A randomized, double-blind, placebo-controlled, dose-escalation study of the safety and efficacy of INCB039110, an oral janus kinase 1 inhibitor, in patients with stable, chronic plaque psoriasis

Artemin, a Glial Cell Line-Derived Neurotrophic Factor Family Member, Induces TRPM8-Dependent Cold Pain

Safety and pharmacokinetics of PF-04360365 following a single-dose intravenous infusion in Japanese subjects with mild-to-moderate Alzheimerâs disease: a multicenter, randomized, double-blind, placebo-controlled, dose-escalation study

Epicutaneous allergen-specific immunotherapy ameliorates grass pollen–induced rhinoconjunctivitis: A double-blind, placebo-controlled dose escalation study

Effect of the Adenosine A1 Receptor Antagonist, KW-3902, on Diuresis and Renal Function in Patients with Acute Decompensated Heart Failure Refractory to Maximum Doses of Conventional Diuretics: A Randomized, Double-Blind, Placebo Controlled, Dose Escalation Study

Safety and pharmacokinetics of PF-04360365 following a single-dose intravenous infusion in Japanese subjects with mild-to-moderate Alzheimerâs disease: a multicenter, randomized, double-blind, placebo-controlled, dose-escalation study