scholarly journals Cell Blebbing upon Addition of Cryoprotectants: A Self-Protection Mechanism

PLoS ONE ◽  
2015 ◽  
Vol 10 (4) ◽  
pp. e0125746 ◽  
Author(s):  
Renquan Ruan ◽  
Lili Zou ◽  
Sijie Sun ◽  
Jing Liu ◽  
Longping Wen ◽  
...  
Keyword(s):  
Protection Mechanism ◽  
Cell Blebbing ◽  
Self Protection

scholarly journals Self-protection Mechanism in d-Cycloserine-producingStreptomyces lavendulae

2004 ◽  
Vol 279 (44) ◽  
pp. 46143-46152 ◽  
Author(s):  
Masafumi Noda ◽  
Yumi Kawahara ◽  
Azusa Ichikawa ◽  
Yasuyuki Matoba ◽  
Hiroaki Matsuo ◽  
...  
Keyword(s):  
Kinetic Studies ◽  
Alanine Racemase ◽  
Protection Mechanism ◽  
E Coli ◽  
Catalytic Activities ◽  
Resistance Determinants ◽  
Streptomyces Lavendulae ◽  
Dependent Inactivation ◽  
Genes Encoding ◽  
Self Protection

An antibiotic,d-cycloserine (DCS), inhibits the catalytic activities of alanine racemase (ALR) andd-alanyl-d-alanine ligase (DDL), which are necessary for the biosynthesis of the bacterial cell wall. In this study, we cloned both genes encoding ALR and DDL, designatedalrSandddlS, respectively, from DCS-producingStreptomyces lavendulaeATCC25233. Each gene product was purified to homogeneity and characterized.Escherichia coli, transformed with a pET vector carryingalrSorddlS, displays higher resistance to DCS than the same host carrying theE. coliALR- or DDL-encoded gene inserted into the pET vector. Although theS. lavendulaeDDL was competitively inhibited by DCS, theKivalue (920 μm) was obviously higher (40∼100-fold) than those forE. coliDdlA (9 μm) or DdlB (27 μm). The highKivalue of theS. lavendulaeDDL suggests that the enzyme may be a self-resistance determinant in the DCS-producing microorganism. Kinetic studies for theS. lavendulaeALR suggest that the time-dependent inactivation rate of the enzyme by DCS is absolutely slower than that of theE. coliALR. We conclude that ALR from DCS-producingS. lavendulaeis also one of the self-resistance determinants.

Toxicity of graphene oxide against algae and cyanobacteria: Nanoblade-morphology-induced mechanical injury and self-protection mechanism

Carbon ◽  
2019 ◽  
Vol 155 ◽  
pp. 386-396 ◽  
Author(s):  
Tomáš Malina ◽  
Eliška Maršálková ◽  
Kateřina Holá ◽  
Jiří Tuček ◽  
Magdalena Scheibe ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Mechanical Injury ◽  
Protection Mechanism ◽  
Self Protection

scholarly journals GW29-e1772 Circulating mir-122-5p: a novel vascular self-protection mechanism in type 2 diabetes

2018 ◽  
Vol 72 (16) ◽  
pp. C58
Author(s):  
Jie Wu ◽  
Xinghua Qin ◽  
Zuoxu Hou ◽  
Xing Zhang ◽  
Feng Gao
Keyword(s):  
Type 2 Diabetes ◽  
Protection Mechanism ◽  
Self Protection

Research on Common Virus Properties in Computer Lab

2014 ◽  
Vol 926-930 ◽  
pp. 2803-2806
Author(s):  
Ji Meng
Keyword(s):  
Damage Effect ◽  
Protection Mechanism ◽  
Computer Lab ◽  
Communication Mechanism ◽  
Self Protection

This paper probes into the properties common virus in computer lab, such as damage effect, communication mechanism and self-protection mechanism, and carries out the important referring materials for Systemic antivirus program of lab based on Restore & Protect Technology.

scholarly journals Comparative Transcriptomic Analysis of the Brain in Takifugu Rubripes Shows Its Tolerance to Acute Hypoxia

2021 ◽  
Author(s):  
Mingxiu Bao ◽  
Fengqin Shang ◽  
Fujun Liu ◽  
Ziwen Hu ◽  
Shengnan Wang ◽  
...  
Keyword(s):  
Acute Hypoxia ◽  
Enrichment Analysis ◽  
Takifugu Rubripes ◽  
Low Oxygen ◽  
Short Term ◽  
Protection Mechanism ◽  
Complete Set ◽  
Self Protection ◽  
The Brain ◽  
Comparative Transcriptomic Analysis

Abstract Hypoxia is reduced levels of oxygen. Especially in water, due to the complex environment, hypoxic situations often occur. Although fish can survive in low-oxygen waters, this survival ability depends on a complete set of coping mechanisms such as oxygen perception and gene-protein interaction regulation. The research on this mechanism is very meaningful. The present study was undertaken to examine the short-term effects of hypoxia on the brain in Takifugu rubripes. We sequenced the transcriptomes of the brain in T. rubripes to studied their response mechanism to acute hypoxia. Total 167 genes with adjusted P values<0.05 were differentially expressed in the brain of T. rubripes exposed to acute hypoxia. However, hif1a, the master transcriptional regulator of the adaptive response to hypoxia, was not significantly regulated, which indicated that the T. rubripes brain might prevent the HIF-1 signaling pathway. Then Gene Ontology and KEGG Enrichment Analysis were carried out. The results indicated that hypoxia could cause metabolic and neurological changes, showing the clues of their adaptation to acute hypoxia. Overall, the sequenced transcriptomes of the brain in T. rubripes showed small changes under acute hypoxia. As the most complex and important organ, the brain of T. rubripes might be able to create a self-protection mechanism to resist or reduce damage caused by acute hypoxia stress.

scholarly journals RNA-seq reveals the pan-transcriptomic impact of attenuating the gliotoxin self-protection mechanism in Aspergillus fumigatus

BMC Genomics ◽  
2014 ◽  
Vol 15 (1) ◽  
pp. 894 ◽  
Author(s):  
Grainne O’Keeffe ◽  
Stephen Hammel ◽  
Rebecca A Owens ◽  
Thomas M Keane ◽  
David A Fitzpatrick ◽  
...  
Keyword(s):  
Aspergillus Fumigatus ◽  
Rna Seq ◽  
Protection Mechanism ◽  
Self Protection
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