scholarly journals Association of Apolipoprotein C3 Genetic Polymorphisms with the Risk of Ischemic Stroke in the Northern Chinese Han Population

PLoS ONE ◽  
2016 ◽  
Vol 11 (9) ◽  
pp. e0163910 ◽  
Author(s):  
Yanzhe Wang ◽  
Xiaoyu Yin ◽  
Lei Li ◽  
Shumin Deng ◽  
Zhiyi He
Keyword(s):  
Ischemic Stroke ◽  
Genetic Polymorphisms ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Apolipoprotein C3 ◽  
Han Population ◽  
Northern Chinese

scholarly journals Genetic polymorphisms in the ALDH2 gene and the risk of ischemic stroke in a Chinese han population

Oncotarget ◽  
2017 ◽  
Vol 8 (60) ◽  
pp. 101936-101943 ◽  
Author(s):  
Shuaiqi Sun ◽  
Jun He ◽  
Yao Zhang ◽  
Rongjun Xiao ◽  
Mengdan Yan ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Genetic Polymorphisms ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Aldh2 Gene

scholarly journals The association between apolipoprotein A1-C3-A5 gene cluster promoter polymorphisms and risk of ischemic stroke in the northern Chinese Han population

2017 ◽  
Vol 45 (6) ◽  
pp. 2042-2052 ◽  
Author(s):  
Yanzhe Wang ◽  
Fang Liu ◽  
Lei Li ◽  
Shumin Deng ◽  
Zhiyi He
Keyword(s):  
Ischemic Stroke ◽  
Gene Cluster ◽  
Apolipoprotein A1 ◽  
Chinese Han Population ◽  
Nucleotide Polymorphisms ◽  
Promoter Polymorphisms ◽  
Chinese Han ◽  
Han Population ◽  
Increased Risk ◽  
Northern Chinese

Objective Given its effects on lipid metabolism, the apolipoprotein A1-C3-A5 ( APOA1-C3-A5) gene cluster is thought to play an important role in ischemic stroke pathogenesis. Here, we evaluated whether the APOA1-C3-A5 cluster is associated with ischemic stroke in the northern Chinese Han population. Methods This case–control study analyzed 812 patients with ischemic stroke and 844 healthy controls with regard to four APOA1-C3-A5 cluster promoter single nucleotide polymorphisms (SNPs), rs670, rs2854116, rs2854117, and rs662799, using the SNaPshot Multiplex sequencing assay. Potential associations among ischemic stroke, genotyping, and allele frequencies were assessed. Results APOA1 rs670 CT/TT genotypes, APOA5 rs662799 AG/GG genotypes, and the APOC3 rs2854116 CC genotype were associated with an increased risk of ischemic stroke according to multivariate logistic analysis after adjusting for confounding factors. A significantly increased risk for ischemic stroke was also identified among high-risk haplotypes (C-C-T-A and T-T-C-A) for rs670–rs2854116–rs2854117–rs662799. Conclusion This study showed that rs670, rs2854116, and rs662799 SNPs of the APOA1-C3-A5 cluster are associated with ischemic stroke in the northern Chinese Han population.

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