scholarly journals Serotype distribution of Streptococcus pneumoniae causing invasive disease in children in the post-PCV era: A systematic review and meta-analysis

PLoS ONE ◽  
2017 ◽  
Vol 12 (5) ◽  
pp. e0177113 ◽  
Author(s):  
Evelyn Balsells ◽  
Laurence Guillot ◽  
Harish Nair ◽  
Moe H. Kyaw
Keyword(s):  
Systematic Review ◽  
Streptococcus Pneumoniae ◽  
Meta Analysis ◽  
Invasive Disease ◽  
Serotype Distribution

scholarly journals The relative invasive disease potential of Streptococcus pneumoniae among children after PCV introduction: A systematic review and meta-analysis

2018 ◽  
Vol 77 (5) ◽  
pp. 368-378 ◽  
Author(s):  
Evelyn Balsells ◽  
Ron Dagan ◽  
Inci Yildirim ◽  
Prabhu P. Gounder ◽  
Anneke Steens ◽  
...  
Keyword(s):  
Systematic Review ◽  
Streptococcus Pneumoniae ◽  
Meta Analysis ◽  
Invasive Disease

scholarly journals Antimicrobial Susceptibility Pattern and Serotype Distribution of Streptococcus Pneumoniae in the Middle East Region: A Systematic Review and MetaAnalysis

2021 ◽  
Author(s):  
Samira Karimaei ◽  
Hamid Reza Tohidinik ◽  
Davoud Afshar ◽  
Mohammad Reza Pourmand ◽  
Soheila Habibi Ghahfarokhi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Streptococcus Pneumoniae ◽  
Middle East ◽  
Meta Analysis ◽  
Resistance Pattern ◽  
Serotype Distribution ◽  
Antimicrobial Susceptibility Pattern ◽  
East Region ◽  
Pooled Prevalence ◽  
Middle East Region

This study aimed to explore the prevalence, antimicrobial resistance levels, and serotype distribution of S. pneumoniae in the Middle East region. We conducted a systematic literature review by searching several databases including PubMed, ISI Web of Science, Scopus, Google scholar through 2000 to 2017 by using the following keywords: “Streptococcus pneumoniae”, “pneumococcus”, “serotype”, “Antibiotic resistance,” and “Middle East “in combination with “OR” and “AND” Boolean Operators within Title/Abstract/Keywords fields. We used a random-effects model to calculate the pooled prevalence and 95% confidence intervals (CIs) for binomial variables. All statistical analyses were done using STATA 12.0 (STATA Corp, College Station, TX). We found 73 articles appropriate, on the word of inclusion and exclusion criteria, for inclusion in this systematic review and meta-analysis. The result revealed that the pooled prevalence of S. pneumoniae carriage was 35% (95% CI: 26-44%). The most frequent pneumococcal serotypes were19, 19F, 6, 23 and 6A/B which were found in 19%,12%, 11%, 10% and 10% of isolates respectively. Pneumococcal resistance reported for azithromycin, cefaclor, clarithromycin, chloramphenicol, erythromycin, and tetracycline were 24%, 37%, 23%, 11%, 26%, and 29% respectively, while vancomycin resistance was not reported. The highest resistant prevalence was reported against co-trimoxazole (Trimethoprim/sulfamethoxazole). For this antibiotic, a pooled resistance prevalence of 43% was identified. The present review demonstrates that the prevalence of S. pneumoniae carriage was high in the Middle East region. Surveillance must be continued in this region to evaluate. The resistance pattern and serotype distribution.

A systematic review and meta-analysis of serotype distribution of Streptococcus pneumoniae in Iran: Practical evidences to optimizing local vaccination protocols

2020 ◽  
Vol 20 ◽  
Author(s):  
Abdollah Karimi ◽  
Seyedeh Mahsan Hoseini-Alfatemi ◽  
Sedigheh Rafiei Tabatabaei
Keyword(s):  
Systematic Review ◽  
Streptococcus Pneumoniae ◽  
Web Of Science ◽  
Data Extraction ◽  
Meta Analysis ◽  
Healthy Individuals ◽  
Inclusion Criteria ◽  
Serotype Distribution ◽  
Invasive Diseases ◽  
Iranian Patients

Background: Little is known regarding the burden of predominant circulating serotypes of Streptococcus pneumoniae in Iran. Therefore, this study aimed to investigate the serotype distribution of pneumococcal diseases in Iran by using a comprehensive systematic review of available articles. Methods: A systematic literature search carried out to identify papers published by Iranian authors in the Web of Science, PubMed, Scopus, Embase and Google Scholar electronic databases since January of 2000 to December of 2018. Then, eight publications which met our inclusion criteria were selected for data extraction and analysis by Comprehensive MetaAnalysis software. Results: Totally, three studies reported the distribution of S. pneumoniae serotypes among patients, two studies among healthy individuals, and three studies among both groups. Of those studies, serotype 19A/F (17.9%; 95% CI: 13.6-23.0) was the most circulating serotype followed by 23A/F (12.3%; 95% CI: 7.7-19.2), 6A/B (11.0%; 95% CI: 8.0-14.9), and 14 (8.8%; 95% CI: 5.8-13.2). In contrast, the lowest circulating serotype was 60 (0.02%; 95% CI: 0.0-1.2), 29 (0.07%; 95% CI: 0.01-5.0), and 36 (0.09%; 95% CI: 0.04-2.1). Meta-regression results showed that prevalence of serotype 23A/F significantly increased each year about 0.2% (95% CI: 0.1- 0.3, P <0.001, tau2 <0.001). Conclusion: In the present study, it was found that over the last decade, the most prevalent serotypes in Iran were 19, 23, 6, and 14, respectively. These findings provides practical evidences to select effective pneumococcal vaccine candidates in the prevention of invasive diseases in Iranian patients, and also comparing our situation with others.

Association of pneumococcal serotype with susceptibility to antimicrobial drugs: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Kristin Andrejko ◽  
Buddhika Ratnasiri ◽  
Joseph A Lewnard
Keyword(s):  
Systematic Review ◽  
Regression Models ◽  
Meta Analysis ◽  
Invasive Disease ◽  
Epidemiologic Studies ◽  
Antimicrobial Drugs ◽  
Conjugate Vaccines ◽  
Post Vaccination ◽  
Resistance Selection ◽  
Pneumococcal Serotype

Abstract Background Pneumococcal serotypes differ in antimicrobial susceptibility. However, patterns and causes of this variation are not comprehensively understood. Methods We undertook a systematic review of epidemiologic studies of pneumococci isolated from carriage or invasive disease among children globally from 2000-2019. We evaluated associations of each serotype with nonsusceptibility to penicillin, macrolides, and trimethoprim/sulfamethoxazole. We evaluated differences in the prevalence of nonsusceptibility to major antibiotic classes across serotypes using random effects meta-regression models, and assessed changes in prevalence of nonsusceptibility after implementation of pneumococcal conjugate vaccines (PCVs). We also evaluated associations between biological characteristics of serotypes and their likelihood of nonsusceptibility to each drug. Results We included data from 129 studies representing 32,187 isolates across 52 countries. Within serotypes, the proportion of nonsusceptible isolates varied geographically and over time, in settings using and those not using PCVs. Factors predicting enhanced fitness of serotypes in colonization as well as enhanced pathogenicity were each associated with higher likelihood of nonsusceptibility to penicillin, macrolides, and trimethoprim/sulfamethoxazole. Increases in prevalence of nonsusceptibility following PCV implementation were evident among non-PCV serotypes including 6A, 6C, 15A, 15B/C, 19A, and 35B; however, this pattern was not universally evident among non-PCV serotypes. Post-vaccination increases in nonsusceptibility for serotypes 6A and 19A were attenuated in settings that implemented PCV13. Conclusions In pneumococci, nonsusceptibility to penicillin, macrolides, and trimethoprim/sulfamethoxazole is associated with more frequent opportunities for antibiotic exposure during both prolonged carriage episodes and when serotypes cause disease. These findings suggest multiple pathways leading to resistance selection in pneumococci.

scholarly journals Serotype distribution of disease-causing Streptococcus pneumoniae in Thailand: A systematic review

Vaccine ◽  
2019 ◽  
Vol 37 (24) ◽  
pp. 3159-3166 ◽  
Author(s):  
Rebecca E. Hocknell ◽  
David W. Cleary ◽  
Somporn Srifeungfung ◽  
Stuart C. Clarke
Keyword(s):  
Systematic Review ◽  
Streptococcus Pneumoniae ◽  
Serotype Distribution

scholarly journals Prevalence of Invasive Streptococcus pneumoniae Infections among Iranian Children: A Systematic Review and Meta-Analysis

2021 ◽  
Author(s):  
Arshid Yousefi Avarvand ◽  
Mehrdad Halaji ◽  
Donya Zare ◽  
Meysam Hasannejad-Bibalan ◽  
Hadi Sedigh Ebrahim-Saraie
Keyword(s):  
Systematic Review ◽  
Streptococcus Pneumoniae ◽  
Web Of Science ◽  
Data Extraction ◽  
Meta Analysis ◽  
Single Center ◽  
Inclusion Criteria ◽  
Pooled Prevalence ◽  
Iranian Children ◽  
The Web

Background: Streptococcus pneumoniae is an important pathogen of children, mostly in developing countries. We aimed to investigate the prevalence of invasive S. pneumoniae among Iranian children using a systematic review and meta-analysis. Methods: A systematic search was carried out to identify papers published by Iranian authors in the Web of Science, PubMed, Scopus, and Google Scholar electronic databases from January of 2010 to December of 2017. Then, seven publications that met our inclusion criteria were selected for data extraction and analysis. Results: Totally, one study was multicenter, and six were single-center based studies. Meanwhile, all of the included studied performed among hospitalized patients. Seven studies reported the prevalence of invasive S. pneumoniae isolated from children, of these the pooled prevalence of S. pneumoniae was 2.5% (95% CI: 0.7%-9.1%). Conclusion: The overall prevalence of invasive S. pneumoniae infections among Iranian children is low (2.5%). However, further clinical studies are required to elucidate the burden of infections among Iranian children, especially in eastern regions.

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