scholarly journals Antimicrobial Susceptibility Pattern and Serotype Distribution of Streptococcus Pneumoniae in the Middle East Region: A Systematic Review and MetaAnalysis

2021 ◽  
Author(s):  
Samira Karimaei ◽  
Hamid Reza Tohidinik ◽  
Davoud Afshar ◽  
Mohammad Reza Pourmand ◽  
Soheila Habibi Ghahfarokhi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Streptococcus Pneumoniae ◽  
Middle East ◽  
Meta Analysis ◽  
Resistance Pattern ◽  
Serotype Distribution ◽  
Antimicrobial Susceptibility Pattern ◽  
East Region ◽  
Pooled Prevalence ◽  
Middle East Region

This study aimed to explore the prevalence, antimicrobial resistance levels, and serotype distribution of S. pneumoniae in the Middle East region. We conducted a systematic literature review by searching several databases including PubMed, ISI Web of Science, Scopus, Google scholar through 2000 to 2017 by using the following keywords: “Streptococcus pneumoniae”, “pneumococcus”, “serotype”, “Antibiotic resistance,” and “Middle East “in combination with “OR” and “AND” Boolean Operators within Title/Abstract/Keywords fields. We used a random-effects model to calculate the pooled prevalence and 95% confidence intervals (CIs) for binomial variables. All statistical analyses were done using STATA 12.0 (STATA Corp, College Station, TX). We found 73 articles appropriate, on the word of inclusion and exclusion criteria, for inclusion in this systematic review and meta-analysis. The result revealed that the pooled prevalence of S. pneumoniae carriage was 35% (95% CI: 26-44%). The most frequent pneumococcal serotypes were19, 19F, 6, 23 and 6A/B which were found in 19%,12%, 11%, 10% and 10% of isolates respectively. Pneumococcal resistance reported for azithromycin, cefaclor, clarithromycin, chloramphenicol, erythromycin, and tetracycline were 24%, 37%, 23%, 11%, 26%, and 29% respectively, while vancomycin resistance was not reported. The highest resistant prevalence was reported against co-trimoxazole (Trimethoprim/sulfamethoxazole). For this antibiotic, a pooled resistance prevalence of 43% was identified. The present review demonstrates that the prevalence of S. pneumoniae carriage was high in the Middle East region. Surveillance must be continued in this region to evaluate. The resistance pattern and serotype distribution.

The prevalence of aflatoxin M1 in milk of Middle East region: A systematic review, meta-analysis and probabilistic health risk assessment

2018 ◽  
Vol 118 ◽  
pp. 653-666 ◽  
Author(s):  
Jamal Rahmani ◽  
Solmaz Alipour ◽  
Ali Miri ◽  
Yadolah Fakhri ◽  
Seyed-Mohammad Riahi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Risk Assessment ◽  
Middle East ◽  
Health Risk ◽  
Health Risk Assessment ◽  
Meta Analysis ◽  
Aflatoxin M1 ◽  
East Region ◽  
Middle East Region

The prevalence of Brucella spp. in dairy products in the Middle East region: A systematic review and meta-analysis

Acta Tropica ◽  
2020 ◽  
Vol 202 ◽  
pp. 105241 ◽  
Author(s):  
Abdol-Samad Abedi ◽  
Fataneh Hashempour-Baltork ◽  
Adel Mirza Alizadeh ◽  
Samira Beikzadeh ◽  
Hedayat Hosseini ◽  
...  
Keyword(s):  
Systematic Review ◽  
Middle East ◽  
Dairy Products ◽  
Meta Analysis ◽  
East Region ◽  
Middle East Region

scholarly journals Seroprevalence of hepatitis C virus infection in Cameroon: a systematic review and meta-analysis

BMJ Open ◽  
2017 ◽  
Vol 7 (8) ◽  
pp. e015748 ◽  
Author(s):  
Jean Joel Bigna ◽  
Marie A Amougou ◽  
Serra Lem Asangbeh ◽  
Angeladine Malaha Kenne ◽  
Jobert Richie Nansseu
Keyword(s):  
Systematic Review ◽  
Hepatitis C ◽  
Methodological Quality ◽  
Meta Analysis ◽  
Hcv Infection ◽  
Representative Study ◽  
East Region ◽  
Pooled Prevalence ◽  
Rural Settings

ObjectiveBetter knowledge of hepatitis C virus (HCV) seroprevalence at the national level can help to implement pertinent strategies to address the HCV-related burden. The aim of this paper was to estimate the seroprevalence of HCV infection in Cameroon.DesignSystematic review and meta-analysis.ParticipantsPeople residing in Cameroon.Data sourcesElectronic databases including PubMed/MEDLINE, AJOL, WHO-Afro Library, Africa Index Medicus, National Institute of Statistics and National AIDS Control Committee, Cameroon from 1 January 2000 to 15 December 2016 were searched. English and French languages papers were considered. Two independent investigators selected studies. The methodological quality of the studies was assessed using the Newcastle–Ottawa scale.Results31 studies including 36 407 individuals were finally considered. There was no national representative study. The overall pooled prevalence was 6.5% (95% CI 4.5% to 8.8%; I²=98.3%). A sensitivity analysis of individuals at low risk of HCV infection showed a pooled prevalence of 3.6% (95% CI 2.3% to 5.2%, I²=97.7%, 18 studies) among 22 860 individuals (general population, blood donors and pregnant women), which was higher than for a high-risk population (healthcare workers and people with other identified comorbidities), 12.2% (95% CI 4.9% to 22.2%; I²=98.3%, 13 studies); p=0.018. The prevalence was higher in the East region, in rural settings, and when using an enzyme immunoassay technique for detecting HCV antibodies. Sex, sites, study period, sample size, timing of data collection and methodological quality of studies were not sources of heterogeneity.LimitationOne-third of studies (29.0%) had a low risk bias in their methodology and most were facility-based (87.1%).ConclusionThe seroprevalence of HCV infection in Cameroon indicates the need for comprehensive and effective strategies to interrupt HCV transmission in the Cameroonian population. Specific attention is needed for the East region of the country, rural settings and high-risk populations. A national representative study is needed to provide better estimates.

scholarly journals A Systematic Review of Childhood Diabetes Research in the Middle East Region

2019 ◽  
Vol 10 ◽  
Author(s):  
Saras Saraswathi ◽  
Sara Al-Khawaga ◽  
Naser Elkum ◽  
Khalid Hussain
Keyword(s):  
Systematic Review ◽  
Middle East ◽  
Diabetes Research ◽  
Childhood Diabetes ◽  
East Region ◽  
Middle East Region

scholarly journals Prevalence of Invasive Streptococcus pneumoniae Infections among Iranian Children: A Systematic Review and Meta-Analysis

2021 ◽  
Author(s):  
Arshid Yousefi Avarvand ◽  
Mehrdad Halaji ◽  
Donya Zare ◽  
Meysam Hasannejad-Bibalan ◽  
Hadi Sedigh Ebrahim-Saraie
Keyword(s):  
Systematic Review ◽  
Streptococcus Pneumoniae ◽  
Web Of Science ◽  
Data Extraction ◽  
Meta Analysis ◽  
Single Center ◽  
Inclusion Criteria ◽  
Pooled Prevalence ◽  
Iranian Children ◽  
The Web

Background: Streptococcus pneumoniae is an important pathogen of children, mostly in developing countries. We aimed to investigate the prevalence of invasive S. pneumoniae among Iranian children using a systematic review and meta-analysis. Methods: A systematic search was carried out to identify papers published by Iranian authors in the Web of Science, PubMed, Scopus, and Google Scholar electronic databases from January of 2010 to December of 2017. Then, seven publications that met our inclusion criteria were selected for data extraction and analysis. Results: Totally, one study was multicenter, and six were single-center based studies. Meanwhile, all of the included studied performed among hospitalized patients. Seven studies reported the prevalence of invasive S. pneumoniae isolated from children, of these the pooled prevalence of S. pneumoniae was 2.5% (95% CI: 0.7%-9.1%). Conclusion: The overall prevalence of invasive S. pneumoniae infections among Iranian children is low (2.5%). However, further clinical studies are required to elucidate the burden of infections among Iranian children, especially in eastern regions.

scholarly journals Prevalence and antimicrobial resistance pattern of Clostridium difficile among hospitalized diarrheal patients: A systematic review and meta-analysis

PLoS ONE ◽  
2022 ◽  
Vol 17 (1) ◽  
pp. e0262597
Author(s):  
Tebelay Dilnessa ◽  
Alem Getaneh ◽  
Workagegnehu Hailu ◽  
Feleke Moges ◽  
Baye Gelaw
Keyword(s):  
Systematic Review ◽  
Clostridium Difficile ◽  
Antimicrobial Resistance ◽  
Antimicrobial Susceptibility ◽  
Susceptibility Testing ◽  
Meta Analysis ◽  
Antimicrobial Susceptibility Testing ◽  
Prevalence Study ◽  
Resistance Pattern ◽  
Pooled Prevalence

Background Clostridium difficile is the leading cause of infectious diarrhea that develops in patients after hospitalization during antibiotic administration. It has also become a big issue in community-acquired diarrhea. The emergence of hypervirulent strains of C. difficile poses a major problem in hospital-associated diarrhea outbreaks and it is difficult to treat. The antimicrobial resistance in C. difficile has worsened due to the inappropriate use of broad-spectrum antibiotics including cephalosporins, clindamycin, tetracycline, and fluoroquinolones together with the emergence of hypervirulent strains. Objective To estimate the pooled prevalence and antimicrobial resistance pattern of C. difficile derived from hospitalized diarrheal patients, a systematic review and meta-analysis was performed. Methods Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline was followed to review published studies conducted. We searched bibliographic databases from PubMed, Scopus, Google Scholar, and Cochrane Library for studies on the prevalence and antimicrobial susceptibility testing on C. difficile. The weighted pooled prevalence and resistance for each antimicrobial agent was calculated using a random-effects model. A funnel plot and Egger’s regression test were used to see publication bias. Results A total of 15 studies were included. Ten articles for prevalence study and 5 additional studies for antimicrobial susceptibility testing of C. difficile were included. A total of 1967/7852 (25%) C. difficile were isolated from 10 included studies for prevalence study. The overall weighted pooled proportion (WPP) of C. difficile was 30% (95% CI: 10.0–49.0; p<0.001). The analysis showed substantial heterogeneity among studies (Cochran’s test = 7038.73, I2 = 99.87%; p<0.001). The weighed pooled antimicrobial resistance (WPR) were: vancomycin 3%(95% CI: 1.0–4.0, p<0.001); metronidazole 5%(95% CI: 3.0–7.0, p<0.001); clindamycin 61%(95% CI: 52.0–69.0, p<0.001); moxifloxacin 42%(95% CI: 29–54, p<0.001); tetracycline 35%(95% CI: 22–49, p<0.001); erythromycin 61%(95% CI: 48–75, p<0.001) and ciprofloxacin 64%(95% CI: 48–80; p< 0.001) using the random effect model. Conclusions A higher weighted pooled prevalence of C. difficile was observed. It needs a great deal of attention to decrease the prevailing prevalence. The resistance of C. difficile to metronidazole and vancomycin was low compared to other drugs used to treat C. difficile infection. Periodic antimicrobial resistance monitoring is vital for appropriate therapy of C. difficile infection.

scholarly journals Molecular mechanisms and epidemiology of resistance in Streptococcus pneumoniae in the Middle East region

2017 ◽  
Vol 66 (7) ◽  
pp. 847-858 ◽  
Author(s):  
Grace El Moujaber ◽  
Marwan Osman ◽  
Rayane Rafei ◽  
Fouad Dabboussi ◽  
Monzer Hamze
Keyword(s):  
Streptococcus Pneumoniae ◽  
Middle East ◽  
Molecular Mechanisms ◽  
East Region ◽  
Middle East Region

scholarly journals Prevalence of Chronic Kidney Diseases in Patients with Diabetes Mellitus in the Middle East: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Abdallah Y Naser ◽  
Hassan Alwafi ◽  
Basil Alotaibi ◽  
Emad Salawati ◽  
Mohammed Samannodi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Middle East ◽  
Study Design ◽  
Kidney Diseases ◽  
Meta Analysis ◽  
Random Effect ◽  
East Region ◽  
Mesh Terms ◽  
Patients With Diabetes ◽  
Middle East Region

Aims. The prevalence of CKD in patients with diabetes mellitus in the Middle East region is unknown. Therefore, we aimed to understand the pooled prevalence of CKD in patients with diabetes mellitus in the Middle East region. Methods. PubMed, Embase, and Cochrane databases were searched for relevant studies up to October 2020. The search strategy was conducted using both keywords and MeSH terms. Randomised controlled trials (RCTs) and observational studies that included patients from all age groups and any study design that reported on the prevalence of CKD in patients with diabetes mellitus were included. The pooled estimate for the prevalence of CKD in patients with diabetes was calculated using random-effect models with 95% confidence intervals (CIs). Results. A total of 489 citations were identified, of which only nine studies matched our inclusion criteria and were included in the meta-analysis. All of the studies used an observational study design covering a total of 59,395 patients with type 2 diabetes mellitus. The pooled estimate of the prevalence of CKD in patients with diabetes mellitus was 28.96% (95% CI: 19.80–38.11). Conclusions. A high prevalence of CKD in patients with diabetes mellitus in the Middle East region was found. Further epidemiological studies are warranted in this area to have a better estimate of the prevalence of CKD among DM in the Middle East region.

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