Prevalence of Invasive Streptococcus pneumoniae Infections among Iranian Children: A Systematic Review and Meta-Analysis

Background: Streptococcus pneumoniae is an important pathogen of children, mostly in developing countries. We aimed to investigate the prevalence of invasive S. pneumoniae among Iranian children using a systematic review and meta-analysis. Methods: A systematic search was carried out to identify papers published by Iranian authors in the Web of Science, PubMed, Scopus, and Google Scholar electronic databases from January of 2010 to December of 2017. Then, seven publications that met our inclusion criteria were selected for data extraction and analysis. Results: Totally, one study was multicenter, and six were single-center based studies. Meanwhile, all of the included studied performed among hospitalized patients. Seven studies reported the prevalence of invasive S. pneumoniae isolated from children, of these the pooled prevalence of S. pneumoniae was 2.5% (95% CI: 0.7%-9.1%). Conclusion: The overall prevalence of invasive S. pneumoniae infections among Iranian children is low (2.5%). However, further clinical studies are required to elucidate the burden of infections among Iranian children, especially in eastern regions.

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A systematic review and meta-analysis of serotype distribution of Streptococcus pneumoniae in Iran: Practical evidences to optimizing local vaccination protocols

Infectious Disorders - Drug Targets ◽

10.2174/1871526519666191002142953 ◽

2020 ◽

Vol 20 ◽

Author(s):

Abdollah Karimi ◽

Seyedeh Mahsan Hoseini-Alfatemi ◽

Sedigheh Rafiei Tabatabaei

Keyword(s):

Systematic Review ◽

Streptococcus Pneumoniae ◽

Web Of Science ◽

Data Extraction ◽

Meta Analysis ◽

Healthy Individuals ◽

Inclusion Criteria ◽

Serotype Distribution ◽

Invasive Diseases ◽

Iranian Patients

Background: Little is known regarding the burden of predominant circulating serotypes of Streptococcus pneumoniae in Iran. Therefore, this study aimed to investigate the serotype distribution of pneumococcal diseases in Iran by using a comprehensive systematic review of available articles. Methods: A systematic literature search carried out to identify papers published by Iranian authors in the Web of Science, PubMed, Scopus, Embase and Google Scholar electronic databases since January of 2000 to December of 2018. Then, eight publications which met our inclusion criteria were selected for data extraction and analysis by Comprehensive MetaAnalysis software. Results: Totally, three studies reported the distribution of S. pneumoniae serotypes among patients, two studies among healthy individuals, and three studies among both groups. Of those studies, serotype 19A/F (17.9%; 95% CI: 13.6-23.0) was the most circulating serotype followed by 23A/F (12.3%; 95% CI: 7.7-19.2), 6A/B (11.0%; 95% CI: 8.0-14.9), and 14 (8.8%; 95% CI: 5.8-13.2). In contrast, the lowest circulating serotype was 60 (0.02%; 95% CI: 0.0-1.2), 29 (0.07%; 95% CI: 0.01-5.0), and 36 (0.09%; 95% CI: 0.04-2.1). Meta-regression results showed that prevalence of serotype 23A/F significantly increased each year about 0.2% (95% CI: 0.1- 0.3, P <0.001, tau2 <0.001). Conclusion: In the present study, it was found that over the last decade, the most prevalent serotypes in Iran were 19, 23, 6, and 14, respectively. These findings provides practical evidences to select effective pneumococcal vaccine candidates in the prevention of invasive diseases in Iranian patients, and also comparing our situation with others.

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Caffeine and Cognitive Functions in Sports: A Systematic Review and Meta-Analysis

Nutrients ◽

10.3390/nu13030868 ◽

2021 ◽

Vol 13 (3) ◽

pp. 868

Author(s):

Jorge Lorenzo Calvo ◽

Xueyin Fei ◽

Raúl Domínguez ◽

Helios Pareja-Galeano

Keyword(s):

Systematic Review ◽

Reaction Time ◽

Cognitive Performance ◽

Cognitive Functions ◽

Web Of Science ◽

Meta Analysis ◽

Caffeine Intake ◽

Inclusion Criteria ◽

Research Protocols ◽

The Relationship

Cognitive functions are essential in any form of exercise. Recently, interest has mounted in addressing the relationship between caffeine intake and cognitive performance during sports practice. This review examines this relationship through a structured search of the databases Medline/PubMed and Web of Science for relevant articles published in English from August 1999 to March 2020. The study followed PRISMA guidelines. Inclusion criteria were defined according to the PICOS model. The identified records reported on randomized cross-over studies in which caffeine intake (as drinks, capsules, energy bars, or gum) was compared to an identical placebo situation. There were no filters on participants’ training level, gender, or age. For the systematic review, 13 studies examining the impacts of caffeine on objective measures of cognitive performance or self-reported cognitive performance were selected. Five of these studies were also subjected to meta-analysis. After pooling data in the meta-analysis, the significant impacts of caffeine only emerged on attention, accuracy, and speed. The results of the 13 studies, nevertheless, suggest that the intake of a low/moderate dose of caffeine before and/or during exercise can improve self-reported energy, mood, and cognitive functions, such as attention; it may also improve simple reaction time, choice reaction time, memory, or fatigue, however, this may depend on the research protocols.

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Glycemic Index of Gluten-Free Bread and Their Main Ingredients: A Systematic Review and Meta-Analysis

Foods ◽

10.3390/foods10030506 ◽

2021 ◽

Vol 10 (3) ◽

pp. 506

Author(s):

Bernardo Romão ◽

Ana Luísa Falcomer ◽

Gabriela Palos ◽

Sandra Cavalcante ◽

Raquel Braz Assunção Botelho ◽

...

Keyword(s):

Systematic Review ◽

Glycemic Index ◽

Resistant Starch ◽

Web Of Science ◽

Meta Analysis ◽

Gluten Free ◽

Inclusion Criteria ◽

Glycemic Profile

This study aimed to perform a systematic review and meta-analysis of the glycemic index (GI) of gluten-free bread (GFB) and its main ingredients. The systematic review followed PRISMA guidelines, using seven electronic databases (PubMed, EMBASE, Scopus, Science Direct, Web of Science, gray literature research with Google Scholar, and patents with Google Patent tool), from inception to November 2020. Eighteen studies met the inclusion criteria evaluating 132 GFB samples. Five articles tested GI in vivo, eleven in vitro; and two studies tested both methods. The analysis showed that 60.7% (95% CI: 40.2–78.1%) of the samples presented high glycemic indexes, evidencing a high glycemic profile for GFB. Only 18.2% (95% CI: 11.7–27.2%) of the bread samples presented in the studies were classified as a low GI. Meta-analysis presented moderate/low heterogenicity between studies (I2 = 61% and <1% for both high and low GIs) and reinforced the proportion of high GIs. Lower GIs were found in formulations based on Colocasia esculenta flour or enriched with fiber, yogurt and curd cheese, sourdough, psyllium, hydrocolloids, enzymes, fructans, and resistant starch, highlighting the efficacy of these ingredients to lower GFBs’ GI. GFB tends to present high GI, impacting the development of chronic diseases when consumed.

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The global prevalence of familial multiple sclerosis: an updated systematic review and meta-analysis

10.21203/rs.3.rs-250607/v1 ◽

2021 ◽

Author(s):

Naeim Ehtesham ◽

Maryam Zare Rafie ◽

Meysam Mosallaei

Keyword(s):

Multiple Sclerosis ◽

Web Of Science ◽

Meta Analysis ◽

Disease Onset ◽

Inclusion Criteria ◽

Multifactorial Diseases ◽

Pooled Prevalence ◽

Significant Difference ◽

Meta Regression ◽

Genetic And Environmental Factors

Abstract Background: Considering that familial multiple sclerosis (FMS) can reveal the extent to which genetic and environmental factors each involve in the etiopathogenesis of the disease, we performed an updated meta-analysis of the worldwide prevalence of FMS by addition of recent publications. Methods: A search in PubMed, Scopus, the ISI Web of Science, and Google Scholar up to 20 December 2020 was done. The inclusion criteria were based on the CoCoPop approach (condition, context, and population). The qualified studies entered the process of the meta-analysis by using comprehensive meta-analysis ver. 2 software.Results: The pooled prevalence of MS in relatives of 16179 FMS cases was estimated to be 11.8% (95% CI: 10.7-13) based on a random-effects model. The pooled mean age of disease onset in adult probands was calculated to be 28.7 years (95% CI: 27.2± 30.2). In 13 studies that reported the data of FMS in pediatrics (n=6636) and adults (n=877), the FMS prevalence was 10.8% (95% CI: 8.1-14.2) and 15.5% (95% CI: 13.8-17.4), respectively. Considering the data of 9 studies, the prevalence of FMS in males (n=5243) and females (n=11503) patients was calculated to be 13.7% (95% CI: 10.1-18.2) and 15.4% (95% CI: 10.3-22.4), respectively. The odds ratio of male/female in FMS cases was not statistically significant (OR= 0.9; 95% CI: 0.6-1.2, P=0.55). Subgroup analysis demonstrated a significant difference in the prevalence of FMS between the geographical areas (P= 0.007). The meta-regression model for FMS prevalence was significantly lower in terms of higher latitude (P< 0.001) and increased MS prevalence (P< 0.001). In contrast, meta-regression based on prevalence day was not statistically significant (P=0.29).Conclusions: The prevalence of FMS is more in the pediatric group than that of adults, is distinct between geographical areas, and diminishes with the increment of MS prevalence and latitude. Also, the symptoms initiate relatively at lower ages in FMS cases. By contrast with multifactorial diseases, our analysis unveiled that the prevalence of FMS was not more prevalent in men than women and the risk of MS development in relatives was not more when the affected proband was male.

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The effect of methadone on depression among addicts: a systematic review and meta-analysis

Health and Quality of Life Outcomes ◽

10.1186/s12955-020-01599-3 ◽

2020 ◽

Vol 18 (1) ◽

Author(s):

Masoud Mohammadi ◽

Mohsen Kazeminia ◽

Nasrin Abdoli ◽

Behnam Khaledipaveh ◽

Shamarina Shohaimi ◽

...

Keyword(s):

Systematic Review ◽

Web Of Science ◽

Treatment Plan ◽

Meta Analysis ◽

Intervention Group ◽

Depression Score ◽

Inclusion Criteria ◽

The World ◽

Before And After ◽

The Mean

Abstract Background Opioids addiction and misuse are among the major problems in the world today. There have been several preliminary studies examining the effect of methadone on depression among addicts, however, these studies have reported inconsistent and even contradictory results. Therefore, the aim of the present study was to determine the effect of methadone on depression in addicts in Iran and around the world, using a meta-analysis approach. Methods This study was a systematic review and meta-analysis including articles published in the SID, MagIran, IranMedex, IranDoc, Cochrane, Embase, ScienceDirect, Scopus, PubMed and Web of Science databases were searched systematically to find articles published from 2006 to March 2019. Heterogeneity index was determined using the Cochran's test (Qc) and I2. Considering heterogeneity of studies, the random effects model was used to estimate the standardized difference of mean score for depression. Subsequently, the level of depression reduction in Iran and worldwide in the intervention group before and after the testwas measured. Results A total of 19 articles met the inclusion criteria, and were therefore selected for this systematic review and meta-analysis. The sample size of the intervention group in the selected studies was 1948. According to the meta-analysis results, the mean depression score in the intervention group was 26.4 ± 5.6 and 18.4 ± 2.6 before and after intervention respectively, indicating the reducing effect of methadone on depression, and this difference was statistically significant (P < 0.01). Conclusion The results of the present study show that methadone significantly reduces depression in addicts. Therefore, regular methadone use can be part of a drug treatment plan.

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Impact of Non-Confinement Accommodation on Farrowing Performance: A Systematic Review and Meta-Analysis of Farrowing Crates Versus Pens

Animals ◽

10.3390/ani9110957 ◽

2019 ◽

Vol 9 (11) ◽

pp. 957 ◽

Cited By ~ 1

Author(s):

Dannielle Glencorse ◽

Kate Plush ◽

Susan Hazel ◽

Darryl D’Souza ◽

Michelle Hebart

Keyword(s):

Systematic Review ◽

Relative Risk ◽

Web Of Science ◽

Meta Analysis ◽

Inclusion Criteria ◽

Literature Searches ◽

Piglet Mortality ◽

Partial Confinement ◽

Meta Analyses ◽

Piglet Survival

There are conflicting reports regarding the effect of farrowing house accommodation on piglet performance. The aim of this investigation was to use a systematic review and meta-analyses to summarise the results of publications that focused on direct comparisons between full confinement conventional crates and various designs of loose-housed farrowing pens from loading until weaning. Literature searches in Scopus, BIOSIS Previews, Cab Abstracts, and Web of Science identified 6695 articles. Twenty-two publications were retained for the systematic review and individual meta-analyses after screening for inclusion criteria. The random effects meta-analyses were performed on crate versus pen for number of piglets born alive, number of stillborn piglets, pre-weaning mortality, and number of piglets weaned. Additionally, the modifiers of confinement length (no confinement from loading until weaning or partial confinement for shorter periods of time in the early stages post parturition), enrichment (no enrichment or enrichment provided), and pen size (small, medium, or large) were examined. There was a 14% increase in the relative risk of piglet mortality in farrowing pens when they were compared with crates (p = 0.0015). The number of stillborns per litter was not different between the pen and crate. However, when providing enrichment in the pens, there was an increase in stillborns within farrowing crates versus pens (p = 0.009). There was no overall effect on piglets that were born alive or number weaned. As there is no difference between piglets born alive and mortality is significantly higher in farrowing pens, a reduction in the number of piglets weaned was expected but not observed, which was possibly due to the lack of weaning details provided in the publications. This was the first systematic review and meta-analysis conducted on the performance of farrowing accommodation and identified that farrowing pens do compromise post-natal piglet survival. Future efforts should focus on improving sow comfort in the farrowing crate to maximize both piglet and sow welfare.

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Prevalence, severity, and nature of preventable patient harm across medical care settings: systematic review and meta-analysis

BMJ ◽

10.1136/bmj.l4185 ◽

2019 ◽

pp. l4185 ◽

Cited By ~ 62

Author(s):

Maria Panagioti ◽

Kanza Khan ◽

Richard N Keers ◽

Aseel Abuzour ◽

Denham Phipps ◽

...

Keyword(s):

Systematic Review ◽

Confidence Interval ◽

Medical Care ◽

Data Extraction ◽

Meta Analysis ◽

Cost Effective ◽

Mitigation Strategies ◽

Patient Harm ◽

Pooled Prevalence ◽

Preventable Harm

Abstract Objective To systematically quantify the prevalence, severity, and nature of preventable patient harm across a range of medical settings globally. Design Systematic review and meta-analysis. Data sources Medline, PubMed, PsycINFO, Cinahl and Embase, WHOLIS, Google Scholar, and SIGLE from January 2000 to January 2019. The reference lists of eligible studies and other relevant systematic reviews were also searched. Review methods Observational studies reporting preventable patient harm in medical care. The core outcomes were the prevalence, severity, and types of preventable patient harm reported as percentages and their 95% confidence intervals. Data extraction and critical appraisal were undertaken by two reviewers working independently. Random effects meta-analysis was employed followed by univariable and multivariable meta regression. Heterogeneity was quantified by using the I 2 statistic, and publication bias was evaluated. Results Of the 7313 records identified, 70 studies involving 337 025 patients were included in the meta-analysis. The pooled prevalence for preventable patient harm was 6% (95% confidence interval 5% to 7%). A pooled proportion of 12% (9% to 15%) of preventable patient harm was severe or led to death. Incidents related to drugs (25%, 95% confidence interval 16% to 34%) and other treatments (24%, 21% to 30%) accounted for the largest proportion of preventable patient harm. Compared with general hospitals (where most evidence originated), preventable patient harm was more prevalent in advanced specialties (intensive care or surgery; regression coefficient b=0.07, 95% confidence interval 0.04 to 0.10). Conclusions Around one in 20 patients are exposed to preventable harm in medical care. Although a focus on preventable patient harm has been encouraged by the international patient safety policy agenda, there are limited quality improvement practices specifically targeting incidents of preventable patient harm rather than overall patient harm (preventable and non-preventable). Developing and implementing evidence-based mitigation strategies specifically targeting preventable patient harm could lead to major service quality improvements in medical care which could also be more cost effective.

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Characteristics of Viral Shedding Time in SARS-CoV-2 Infections: A Systematic Review and Meta-Analysis

Frontiers in Public Health ◽

10.3389/fpubh.2021.652842 ◽

2021 ◽

Vol 9 ◽

Author(s):

Danying Yan ◽

Xiaobao Zhang ◽

Can Chen ◽

Daixi Jiang ◽

Xiaoxiao Liu ◽

...

Keyword(s):

Systematic Review ◽

Chronic Diseases ◽

Clinical Characteristics ◽

Web Of Science ◽

Meta Analysis ◽

Corticosteroid Treatment ◽

Inclusion Criteria ◽

Viral Shedding ◽

Stool Specimens ◽

Asymptomatic Infections

Background: The viral shedding time (VST) of SARS-CoV-2 mainly determines its transmission and duration of infectiousness. However, it was heterogeneous in the existing studies. Here, we performed a meta-analysis to comprehensively summarize the VST of SARS-CoV-2.Methods: We searched PubMed, Web of Science, MedRxiv, BioRxiv, CNKI, CSTJ, and Wanfang up to October 25, 2020, for studies that reported VSTs of SARS-CoV-2. Pooled estimates and 95% CIs for the VSTs were calculated using log-transformed data. The VSTs in SARS-CoV-2 infections based on different demographic and clinical characteristics, treatments and specimens were stratified by subgroup analysis.Results: A total of 35 studies involving 3,385 participants met the inclusion criteria. The pooled mean VST was 16.8 days (95% CI: 14.8–19.4, I2 = 99.56%) in SARS-CoV-2 infections. The VST was significantly longer in symptomatic infections (19.7 days, 95% CI: 17.2–22.7, I2 = 99.34%) than in asymptomatic infections (10.9 days, 95% CI: 8.3–14.3, I2 = 98.89%) (P < 0.05). The VST was 23.2 days (95% CI: 19.0–28.4, I2 = 99.24%) in adults, which was significantly longer than that in children (9.9 days, 95% CI: 8.1–12.2, I2 = 85.74%) (P < 0.05). The VST was significantly longer in persons with chronic diseases (24.2 days, 95% CI: 19.2–30.2, I2 = 84.07%) than in those without chronic diseases (11.5 days, 95% CI: 5.3–25.0, I2 = 82.11%) (P < 0.05). Persons receiving corticosteroid treatment (28.3 days, 95% CI: 25.6–31.2, I2 = 0.00%) had a longer VST than those without corticosteroid treatment (16.2 days, 95% CI: 11.5–22.5, I2 = 92.27%) (P = 0.06). The VST was significantly longer in stool specimens (30.3 days, 95% CI: 23.1–39.2, I2 = 92.09%) than in respiratory tract specimens (17.5 days, 95% CI: 14.9–20.6, I2 = 99.67%) (P < 0.05).Conclusions: A longer VST was found in symptomatic infections, infected adults, persons with chronic diseases, and stool specimens.

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Circulating adipokines in non-obese PCOS patients: a systematic review and meta-analysis

10.1101/2020.10.11.20210716 ◽

2020 ◽

Author(s):

Kainan Lin ◽

Xiaoting Sun ◽

Xiao Wang ◽

Hanchu Wang ◽

Xia Chen

Keyword(s):

Systematic Review ◽

Polycystic Ovary Syndrome ◽

Web Of Science ◽

Polycystic Ovary ◽

Meta Analysis ◽

Scientific Evidence ◽

Inclusion Criteria ◽

Ovary Syndrome ◽

Literature Research ◽

Circulating Levels

AbstractConcentrations of circulating adipokines in non-obese polycystic ovary syndrome (PCOS) patients had been reported in many researches, however, these results were conflicting. The aim of this meta-analysis was to assess whether the levels of circulating adipokines were changed in non-obese PCOS. To identify eligible studies, literature research was performed in the database of PubMed, Embase, Web of Science without the restriction of region, publication or language. Of the total studies found, only 81 met the inclusion criteria. The meta-analysis showed that circulating levels of adiponectin [-0.95 (95% CI, −1.36 to −0.53)] decreased statistically in non-obese PCOS women. On the contrary, circulating levels of chemerin [1.13 (95% CI, 0.08 to 2.18)], leptin [0.47 (95% CI, 0.13 to 0.81)], resistin [0.45 (95% CI, 0.03 to 0.88)] and visfatin [1.38 (95% CI, 0.68 to 2.09)] increased significantly in non-obese PCOS females. Besides, there was no statistically significant change in the circulating levels of apelin [0.32 (95% CI, −1.34 to 1.99), irisin [1.01(95% CI, −0.68 to 2.70), omentin [-0.37(95% CI, −1.05 to 0.31)] and vaspin [0.09(95% CI, −0.14 to 0.32)] in non-obese PCOS patients. Scientific evidence suggested that the levels of circulating adipokines altered in non-obese PCOS patients compared with controls. Independent of the degree of obesity, the abnormal change of circulating adipokines levels might play an important role in the occurrence and development of PCOS.

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Prevalence and incidence of type 1 diabetes in the world: a systematic review and meta-analysis

Health Promotion Perspectives ◽

10.34172/hpp.2020.18 ◽

2020 ◽

Vol 10 (2) ◽

pp. 98-115 ◽

Cited By ~ 11

Author(s):

Majid Mobasseri ◽

Masoud Shirmohammadi ◽

Tarlan Amiri ◽

Nafiseh Vahed ◽

Hossein Hosseini Fard ◽

...

Keyword(s):

Systematic Review ◽

Type 1 Diabetes ◽

Web Of Science ◽

Meta Analysis ◽

Inclusion Criteria ◽

Glucose Levels ◽

The World ◽

Multiple Levels ◽

English Articles

Background: Diabetes is referred to a group of diseases characterized by high glucose levels in blood. It is caused by a deficiency in the production or function of insulin or both, which can occur because of different reasons, resulting in protein and lipid metabolic disorders. The aim of this study was to systematically review the prevalence and incidence of type 1 diabetes in the world. Methods: A systematic search of resources was conducted to investigate the prevalence and incidence of type 1 diabetes in the world. The databases of Medline (via PubMed and Ovid),ProQuest, Scopus, and Web of Science from January 1980 to September 2019 were searched to locate English articles. The located articles were screened in multiple levels of title, abstract,and full-text and final studies that met the inclusion criteria were retrieved and included in the study. Results: From 1202 located articles, 193 studies were included in this systematic review. The results of meta-analysis showed that the incidence of type 1 diabetes was 15 per 100,000 people and the prevalence was 9.5% (95% CI: 0.07 to 0.12) in the world, which was statistically significant. Conclusion: According to the results, the incidence and prevalence of type 1 diabetes are increasing in the world. As a result, insulin will be difficult to access and afford, especially in underdeveloped and developing countries.

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