Nasopharyngeal colonisation with Streptococcus pneumoniae in malnourished children: a systematic review and meta-analysis of prevalence

Background: Streptococcus pneumoniae is an important pathogen of children, mostly in developing countries. We aimed to investigate the prevalence of invasive S. pneumoniae among Iranian children using a systematic review and meta-analysis. Methods: A systematic search was carried out to identify papers published by Iranian authors in the Web of Science, PubMed, Scopus, and Google Scholar electronic databases from January of 2010 to December of 2017. Then, seven publications that met our inclusion criteria were selected for data extraction and analysis. Results: Totally, one study was multicenter, and six were single-center based studies. Meanwhile, all of the included studied performed among hospitalized patients. Seven studies reported the prevalence of invasive S. pneumoniae isolated from children, of these the pooled prevalence of S. pneumoniae was 2.5% (95% CI: 0.7%-9.1%). Conclusion: The overall prevalence of invasive S. pneumoniae infections among Iranian children is low (2.5%). However, further clinical studies are required to elucidate the burden of infections among Iranian children, especially in eastern regions.

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Serotype distribution of Streptococcus pneumoniae causing invasive disease in children in the post-PCV era: A systematic review and meta-analysis

PLoS ONE ◽

10.1371/journal.pone.0177113 ◽

2017 ◽

Vol 12 (5) ◽

pp. e0177113 ◽

Cited By ~ 123

Author(s):

Evelyn Balsells ◽

Laurence Guillot ◽

Harish Nair ◽

Moe H. Kyaw

Keyword(s):

Systematic Review ◽

Streptococcus Pneumoniae ◽

Meta Analysis ◽

Invasive Disease ◽

Serotype Distribution

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Serotype distribution of Streptococcus pneumoniae and potential impact of pneumococcal conjugate vaccines in China: A systematic review and meta-analysis

Human Vaccines & Immunotherapeutics ◽

10.1080/21645515.2018.1435224 ◽

2018 ◽

Vol 14 (6) ◽

pp. 1453-1463 ◽

Cited By ~ 10

Author(s):

Kaile Chen ◽

Xiyan Zhang ◽

Wei Shan ◽

Genming Zhao ◽

Tao Zhang

Keyword(s):

Systematic Review ◽

Streptococcus Pneumoniae ◽

Meta Analysis ◽

Serotype Distribution ◽

Conjugate Vaccines ◽

Pneumococcal Conjugate Vaccines ◽

Potential Impact

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Streptococcus pneumoniae as a Cause of Community-Acquired Pneumonia in Indian Adolescents and Adults: A Systematic Review and Meta-Analysis

Clinical Medicine Insights Circulatory Respiratory and Pulmonary Medicine ◽

10.1177/1179548419862790 ◽

2019 ◽

Vol 13 ◽

pp. 117954841986279 ◽

Cited By ~ 1

Author(s):

Canna J. Ghia ◽

Raja Dhar ◽

Parvaiz A Koul ◽

Gautam Rambhad ◽

Mark A Fletcher

Keyword(s):

Systematic Review ◽

Streptococcus Pneumoniae ◽

Legionella Pneumophila ◽

Science Communication ◽

Meta Analysis ◽

Community Acquired Pneumonia ◽

Hand Search ◽

Indian Patients ◽

Adolescents And Adults ◽

Etiological Agents

Background: Streptococcus pneumoniae is one of the primary cause of community-acquired pneumonia (CAP) worldwide. However, scant data are available on the prevalence of etiological organisms for CAP in adolescent and adult Indian population. Objective: We performed a systematic review and meta-analysis to determine the contribution of S. pneumoniae in the causation of CAP in Indian patients aged 12 years or above. Methodology: We performed a systematic search of both indexed and non-indexed publications using PubMed, databases of National Institute of Science Communication and Information Resources (NISCAIR), Annotated Bibliography of Indian Medicine (ABIM), Google Scholar, and hand search including cross-references using key terms ‘community acquired pneumonia AND India’. All studies, published between January 1990 and January 2017, that evaluated Indian patients aged above 12 years with a confirmed diagnosis of CAP were eligible for inclusion. Our search retrieved a total of 182 studies, of which only 17 and 12 qualified for inclusion in the systematic review of all etiological organisms, and meta-analysis of S. pneumonia, respectively. Results: A total of 1435 patients met the inclusion criteria. The pooled proportion of patients with S. pneumoniae infection was 19% (95% confidence interval [CI]: 12%-26%; I2 = 94.5% where I2 represents heterogeneity, P < .01). Other major etiological agents are Mycoplasma pneumoniae (15.5% [1.1%-35.5%]), Klebsiella pneumoniae (10.5% [1.6%-24.0%]), and Legionella pneumophila (7.3% [2.5%-23.8%]). Conclusions: Analysis found approximately a one-fifth proportion of adult Indian patients of CAP with S. pneumoniae infection, suggesting it as a leading organism for causing CAP compared with other etiological organisms.

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Carriage of Streptococcus pneumoniae and Other Respiratory Bacterial Pathogens in Low and Lower-Middle Income Countries: A Systematic Review and Meta-Analysis

PLoS ONE ◽

10.1371/journal.pone.0103293 ◽

2014 ◽

Vol 9 (8) ◽

pp. e103293 ◽

Cited By ~ 89

Author(s):

Richard A. Adegbola ◽

Rodrigo DeAntonio ◽

Philip C. Hill ◽

Anna Roca ◽

Effua Usuf ◽

...

Keyword(s):

Systematic Review ◽

Streptococcus Pneumoniae ◽

Bacterial Pathogens ◽

Meta Analysis ◽

Middle Income ◽

Middle Income Countries

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Streptococcus pneumoniae serotype 19A in Latin America and the Caribbean: a systematic review and meta-analysis, 1990–2010

BMC Infectious Diseases ◽

10.1186/1471-2334-12-124 ◽

2012 ◽

Vol 12 (1) ◽

Cited By ~ 15

Author(s):

Elizabeth Castañeda ◽

Clara Inés Agudelo ◽

Rodrigo De Antonio ◽

Diego Rosselli ◽

Claudia Calderón ◽

...

Keyword(s):

Systematic Review ◽

Latin America ◽

Streptococcus Pneumoniae ◽

Meta Analysis ◽

The Caribbean

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Antimicrobial Susceptibility Pattern and Serotype Distribution of Streptococcus Pneumoniae in the Middle East Region: A Systematic Review and MetaAnalysis

ACTA MEDICA IRANICA ◽

10.18502/acta.v59i2.5572 ◽

2021 ◽

Author(s):

Samira Karimaei ◽

Hamid Reza Tohidinik ◽

Davoud Afshar ◽

Mohammad Reza Pourmand ◽

Soheila Habibi Ghahfarokhi ◽

...

Keyword(s):

Systematic Review ◽

Streptococcus Pneumoniae ◽

Middle East ◽

Meta Analysis ◽

Resistance Pattern ◽

Serotype Distribution ◽

Antimicrobial Susceptibility Pattern ◽

East Region ◽

Pooled Prevalence ◽

Middle East Region

This study aimed to explore the prevalence, antimicrobial resistance levels, and serotype distribution of S. pneumoniae in the Middle East region. We conducted a systematic literature review by searching several databases including PubMed, ISI Web of Science, Scopus, Google scholar through 2000 to 2017 by using the following keywords: “Streptococcus pneumoniae”, “pneumococcus”, “serotype”, “Antibiotic resistance,” and “Middle East “in combination with “OR” and “AND” Boolean Operators within Title/Abstract/Keywords fields. We used a random-effects model to calculate the pooled prevalence and 95% confidence intervals (CIs) for binomial variables. All statistical analyses were done using STATA 12.0 (STATA Corp, College Station, TX). We found 73 articles appropriate, on the word of inclusion and exclusion criteria, for inclusion in this systematic review and meta-analysis. The result revealed that the pooled prevalence of S. pneumoniae carriage was 35% (95% CI: 26-44%). The most frequent pneumococcal serotypes were19, 19F, 6, 23 and 6A/B which were found in 19%,12%, 11%, 10% and 10% of isolates respectively. Pneumococcal resistance reported for azithromycin, cefaclor, clarithromycin, chloramphenicol, erythromycin, and tetracycline were 24%, 37%, 23%, 11%, 26%, and 29% respectively, while vancomycin resistance was not reported. The highest resistant prevalence was reported against co-trimoxazole (Trimethoprim/sulfamethoxazole). For this antibiotic, a pooled resistance prevalence of 43% was identified. The present review demonstrates that the prevalence of S. pneumoniae carriage was high in the Middle East region. Surveillance must be continued in this region to evaluate. The resistance pattern and serotype distribution.

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