Correlations between local peripapillary choroidal thickness and axial length, optic disc tilt, and papillo-macular position in young healthy eyes

BackgroundEnlargement of optic disc cupping is seen both in glaucoma and in neurological disorders. We used enhanced depth imaging with spectral-domain optical coherence tomography to differentiate glaucoma from non-glaucomatous optic neuropathy.MethodsThe optic discs were scanned in this prospective comparative study, and the lamina cribrosa (LC) thickness and anterior laminar depth (ALD) in the central, superior and inferior optic nerve head, and peripapillary choroidal thicknesses, were measured.ResultsThere were 31 eyes of 31 patients with severe glaucoma and 33 eyes of 19 patients with non-glaucomatous cupping. Eyes of 29 healthy controls were also enrolled. There was no significant difference in the cup-to-disc ratio and in the average peripapillary nerve fibre layer thickness between the glaucoma and non-glaucomatous cupping groups (p>0.99). The average peripapillary choroidal thickness was thinner in glaucoma eyes than in the control eyes after adjusting for age and axial length. Glaucomatous and non-glaucomatous eyes had greater ALD and thinner LC than the control eyes (p<0.001 for both). ALDs of glaucoma eyes were deeper than non-glaucomatous eyes (p=0.01 for central ALD) when age, axial length and peripapillary choroidal thickness were included in the linear mixed model. Prelaminar thickness and LC thickness of glaucoma eyes were not different from non-glaucomatous eyes after adjusting.ConclusionDeeper ALD was observed in glaucoma than non-glaucomatous cupping after adjusting for choroidal thickness.

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Retinal and Choroidal Changes in Children with Moderate-to-High Hyperopia

Journal of Ophthalmology ◽

10.1155/2021/9971564 ◽

2021 ◽

Vol 2021 ◽

pp. 1-7

Author(s):

Yu Qian ◽

Yingyan Ma ◽

Qiurong Lin ◽

Zhaoyu Xiang ◽

Jun Qiang ◽

...

Keyword(s):

Optic Disc ◽

Axial Length ◽

Choroidal Thickness ◽

Cross Sectional Study ◽

Fiber Layer ◽

Cross Sectional ◽

Swept Source ◽

Uncorrected Visual Acuity ◽

Spherical Equivalent Refraction ◽

High Hyperopia

Purpose. This study aimed to investigate the characteristics of retinal nerve fiber layer (RNFL) thickness, ganglion cell layer (GCL) thickness, and choroidal thickness in children with moderate-to-high hyperopia (MHH). Methods. This was a cross-sectional study that enrolled 53 children with MHH and 53 emmetropic children. Subjects with a spherical equivalent refraction (SER) of +4.0 D or higher were included in the MHH group, and subjects with SER between −1.0 D and +1.0 D were included in the emmetropic group. Ophthalmic examinations, including uncorrected visual acuity, cycloplegic refraction, slit-lamp examination, axial length, and swept-source optical coherence tomography (SS-OCT; DRI OCT Triton-1, Topcon, Tokyo, Japan), were performed. Results. The RNFL and GCL in the temporal and inferior quadrants in 1–3 mm of the macular fovea were thinner in the MHH group than in the emmetropic group (all P < 0.05 ). The MHH group also had a thicker choroidal thickness in all regions (all P < 0.05 ). The SER was independently correlated with the average choroidal thickness in the optic disc and fovea (coefficient = 4.853, P < 0.001 for the optic disc; coefficient = 5.523, P = 0.004 for the fovea), while axial length was negatively correlated with choroidal thickness (coefficient = −12.649, P < 0.001 ). Axial length was positively associated with RNFL and GCL thickness in the temporal quadrant in 1–3 mm of the macular fovea (coefficient = 0.966, P = 0.007 for RNFL and coefficient = 1.476, P = 0.011 for the macular fovea). Conclusion. Compared with emmetropic children, MMH children had greater choroidal thickness. The characteristics of the RNFL and GCL thickness in MMH children were different from those in emmetropic children.

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Association of retinal thickness and optic disc-to-fovea angle to axial length of young healthy eyes

Clinical Ophthalmology ◽

10.2147/opth.s93197 ◽

2015 ◽

pp. 2235 ◽

Cited By ~ 6

Author(s):

Takehiro Yamashita ◽

Taiji Sakamoto ◽

Hiroto Terasaki ◽

Minoru Tanaka ◽

Yuya Kii ◽

...

Keyword(s):

Optic Disc ◽

Axial Length ◽

Retinal Thickness ◽

Healthy Eyes

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Peripapillary choroidal thickness in eyes with high myopia

Journal of International Medical Research ◽

10.1177/0300060520917273 ◽

2020 ◽

Vol 48 (4) ◽

pp. 030006052091727

Author(s):

Aiping Song ◽

Xincen Hou ◽

Jian Zhuo ◽

Tao Yu

Keyword(s):

Axial Length ◽

Choroidal Thickness ◽

Pearson Correlation ◽

Chinese Patients ◽

Enhanced Depth Imaging ◽

Continuous Variables ◽

Peripapillary Choroidal Thickness ◽

Temporal Quadrant ◽

Inferior Quadrant ◽

Myopic Maculopathy

Objective To investigate characteristics of peripapillary choroidal thickness (PCT) in Chinese patients with myopia without myopic maculopathy. Methods We retrospectively assessed 95 Chinese patients (95 eyes) with myopia without myopic maculopathy, who had visited the myopia clinic of Shandong Provincial Qianfoshan Hospital. Thirteen patients were excluded; the remaining 82 patients were divided into Groups 1 (spherical equivalent [SE], −0.5 to −6.0 D; axial length, 24–26 mm; n = 26), 2 (SE, −6.0 to −10.0 D; axial length, 26 to 28 mm; n = 34), and 3 (SE, ≥−10.0 D; axial length, ≥28 mm; n = 22). Enhanced depth imaging optical coherence tomography was used to measure PCT in inferior, superior, nasal, and temporal quadrants. Continuous variables were compared using one-way analysis of variance. Associations of PCT with SE and axial length were analyzed by Pearson correlation. Results PCT decreased with increasing SE and axial length in all quadrants. For each group, PCT was thickest in the temporal quadrant and thinnest in the inferior quadrant. PCT significantly differed between Groups 1 and 3 in superior, nasal, and temporal quadrants. Conclusions PCT decreased with increasing SE and axial length. PCT was thickest in the temporal quadrant and thinnest in the inferior quadrant in Chinese patients with myopia.

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