scholarly journals Magnetic resonance imaging of the hand and wrist in a randomized, double-blind, multicenter, placebo-controlled trial of infliximab for rheumatoid arthritis: Comparison of dynamic contrast enhanced assessments with semi-quantitative scoring

PLoS ONE ◽  
2017 ◽  
Vol 12 (12) ◽  
pp. e0187397 ◽  
Author(s):  
Chan Beals ◽  
Richard Baumgartner ◽  
Charles Peterfy ◽  
Andra Balanescu ◽  
Gavrila Mirea ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Controlled Trial ◽  
Resonance Imaging ◽  
Double Blind ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced ◽  
Quantitative Scoring

Assessing Associations of Synovial Perfusion, Cartilage Quality, and Outcome in Rheumatoid Arthritis Using Dynamic Contrast-enhanced Magnetic Resonance Imaging

2019 ◽  
Vol 47 (1) ◽  
pp. 15-19 ◽  
Author(s):  
Philipp Sewerin ◽  
Christoph Schleich ◽  
Ralph Brinks ◽  
Anja Müller-Lutz ◽  
Florian Fichter ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Resonance Imaging ◽  
Dynamic Contrast Enhanced ◽  
European League Against Rheumatism ◽  
Contrast Enhanced ◽  
Treatment Naïve ◽  
And Cartilage ◽  
European League

Objective.To assess associations of synovial perfusion, cartilage quality, and outcome in rheumatoid arthritis (RA).Methods.Synovial perfusion and cartilage quality were assessed by dynamic contrast-enhanced magnetic resonance imaging in metacarpophalangeal joints of 28 treatment-naive patients with RA at baseline and at 3 and 6 months after methotrexate. Analysis was by linear mixed modeling.Results.Synovial perfusion variables were associated with remission (p < 0.05) and cartilage quality (p < 0.004). Maximum synovial enhancement was associated to European League Against Rheumatism response (p < 0.05). Synovial perfusion improved in nonresponders over time (p < 0.05).Conclusion.Synovial perfusion relates to remission, response, and cartilage quality in a cohort of therapy-naive patients with early RA.

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