Correction: Developmental milestones of the autonomic nervous system revealed via longitudinal monitoring of fetal heart rate variability

The objective: to establish the features of fetus functional state definition in pregnant women with perinatal losses in history. Patients and methods. 89 pregnant women with perinatal losses in history were screened. The fetus functional status evaluation was based on cardiotocography and definition of fetal heart rate variability by cardiointervalography. Results. Received data showed the decrease of SDNN, RMSSD and pNN50 in pregnant women with perinatal losses in history, indicating the prevalence of parasympathetic effects on the fetal myocardium (p<0.05). Studies of mathematical time characteristics of fetal heart rate revealed a significant overweight of the metabolic-humoral regulatory circuit in women with normal pregnancy (p<0.05). Dynamic stress index evaluation indicates the centralization of heart rate regulation and significant intensity of the fetal compensatory mechanisms in pregnant women with perinatal losses in history. The cardiotocography revealed no difference between the fetal status in women of comparative groups (p>0.05). Conclusions. In pregnant women with perinatal losses in history owing to autonomic nervous system disregulation a significant intensity of fetal regulatory systems and the centralization of fetal cardiac rhythm control were observed. The cardiotocography and cardiointervalography data with revealed signs of excessive sympathetic activation can serve as preclinical signs of gestational pathology. Key words: perinatal losses, fetal functional state evaluation, cardiotocography, cardiointervalography, autonomic nervous system.

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The fetal autonomic nervous system, the fetal heart rate and the beat-to-beat irregularity

European Journal of Obstetrics & Gynecology and Reproductive Biology ◽

10.1016/0028-2243(77)90066-1 ◽

1977 ◽

Vol 7 (6) ◽

pp. 373-376 ◽

Cited By ~ 5

Author(s):

J. Kleinhout ◽

L.A.M. Stolte ◽

J. Janssens ◽

A.A. Knoop

Keyword(s):

Heart Rate ◽

Nervous System ◽

Autonomic Nervous System ◽

Fetal Heart Rate ◽

Fetal Heart ◽

Autonomic Nervous

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Differences in the Asymmetry of Beat-to-Beat Fetal Heart Rate Accelerations and Decelerations at Preterm and Term Active Labor

Sensors ◽

10.3390/s21248249 ◽

2021 ◽

Vol 21 (24) ◽

pp. 8249

Author(s):

Carolina López-Justo ◽

Adriana Cristina Pliego-Carrillo ◽

Claudia Ivette Ledesma-Ramírez ◽

Hugo Mendieta-Zerón ◽

Miguel Ángel Peña-Castillo ◽

...

Keyword(s):

Heart Rate ◽

Nervous System ◽

Autonomic Nervous System ◽

Fetal Heart Rate ◽

Fetal Heart ◽

System Response ◽

Cardiac Autonomic Nervous System ◽

Autonomic Nervous ◽

Active Labor ◽

The Asymmetry

The fetal autonomic nervous system responds to uterine contractions during active labor as identified by changes in the accelerations and decelerations of fetal heart rate (FHR). Thus, this exploratory study aimed to characterize the asymmetry differences of beat-to-beat FHR accelerations and decelerations in preterm and term fetuses during active labor. In an observational study, we analyzed 10 min of fetal R-R series collected from women during active preterm labor (32–36 weeks of pregnancy, n = 17) and active term labor (38–40 weeks or pregnancy, n = 27). These data were used to calculate the Deceleration Reserve (DR), which is a novel parameter that quantifies the asymmetry of the average acceleration and deceleration capacity of the heart. In addition, relevant multiscale asymmetric indices of FHR were also computed. Lower values of DR, calculated with the input parameters of T = 50 and s = 10, were associated with labor occurring at the preterm condition (p = 0.0131). Multiscale asymmetry indices also confirmed significant (p < 0.05) differences in the asymmetry of FHR. Fetuses during moderate premature labor may experience more decaying R-R trends and a lower magnitude of decelerations compared to term fetuses. These differences of FHR dynamics might be related to the immaturity of the fetal cardiac autonomic nervous system as identified by this system response to the intense uterine activity at active labor.

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Assessments of Heart Rate and Sympathetic and Parasympathetic Nervous Activities of Normal Mouse Fetuses at Different Stages of Fetal Development Using Fetal Electrocardiography

Frontiers in Physiology ◽

10.3389/fphys.2021.652828 ◽

2021 ◽

Vol 12 ◽

Author(s):

Yoshiyuki Kasahara ◽

Chihiro Yoshida ◽

Masatoshi Saito ◽

Yoshitaka Kimura

Keyword(s):

Heart Rate ◽

Nervous System ◽

Autonomic Nervous System ◽

Fetal Heart Rate ◽

Fetal Heart ◽

Nervous Activity ◽

Parasympathetic Activity ◽

Autonomic Nerves ◽

Autonomic Nervous ◽

Mouse Fetuses

Heart rate is controlled by the activity of the autonomic nervous system: the sympathetic and parasympathetic nervous systems increase and suppress heart rate, respectively. To evaluate the activity of the autonomic nervous system, it is possible to determine heart rate variability using electrocardiography (ECG). During the fetal period, the heart and autonomic nerves develop in coordination; however, physiological changes, including autonomic nervous activities that occur during the fetal stage, remain largely unknown. Therefore, in this study, we measured ECG signals of mouse fetuses using our established method to evaluate the development of heart rate and autonomic nervous activity at different fetal developmental stages. We found that heart rate was significantly increased in fetal mice at embryonic day (E) 18.5 compared with that at E13.5, E15.5, and E17.5, indicating that fetal heart rate increases only at the stage immediately prior to birth. Interestingly, fetal parasympathetic nervous activity was reduced at E17.5 and E18.5 compared with that at E13.5, whereas fetal sympathetic nervous activity remained unchanged, at least from E13.5 to E18.5. These results indicate that parasympathetic activity rather than sympathetic activity affects fetal heart rate and that the decrease in parasympathetic activity toward the end of pregnancy could result in the observed increase in fetal heart rate.

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Spectral analysis of heart rate variability signal for the assessment of autonomic nervous system behavior

Electroencephalography and Clinical Neurophysiology ◽

10.1016/s0013-4694(97)88086-1 ◽

1997 ◽

Vol 103 (1) ◽

pp. 41

Author(s):

S Cerutti

Keyword(s):

Heart Rate ◽

Heart Rate Variability ◽

Nervous System ◽

Spectral Analysis ◽

Autonomic Nervous System ◽

System Behavior ◽

Autonomic Nervous

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Efeito da manipulação vertebral sobre a modulação autonômica cardíaca

Fisioterapia Brasil ◽

10.33233/fb.v17i5.685 ◽

2016 ◽

Vol 17 (5) ◽

pp. 498

Author(s):

Alyssa Conte Da Silva ◽

Juliana Falcão Padilha ◽

Jefferson Luiz Brum Marques ◽

Cláudia Mirian De Godoy Marques

Keyword(s):

Heart Rate ◽

Heart Rate Variability ◽

Nervous System ◽

Autonomic Nervous System ◽

Spinal Manipulation ◽

Autonomic Modulation ◽

Autonomic Nervous ◽

Cardiac Autonomic Modulation

Introdução: Existem poucos estudos que evidenciam a manipulação vertebral relacionada à modulação autonômica cardíaca. Objetivo: Revisar a literatura sobre os efeitos da manipulação vertebral sobre a modulação autonômica cardíaca. Métodos: Foi realizada uma busca bibliográfica nas bases de dados da saúde Medline, Pubmed e Cinahl, no período correspondido entre setembro e novembro de 2014. Foram utilizados os descritores em inglês Spinal Manipulation, Cardiac Autonomic Modulation, Autonomic Nervous System, Heart Rate Variability, além de associações entre eles. Resultados: Foram encontrados 190 artigos, sendo excluídos 39 por serem repetidos, restando 151. Destes, 124 não se encaixaram nos critérios de inclusão e após leitura crítica e análise dos materiais foram selecionados 7 artigos. Grande parte dos estudos revelou que a manipulação da coluna, independente do segmento, demonstra alterações autonômicas, tanto em nível simpático quanto parassimpático. Conclusão: Existem diferentes metodologias para avaliação da modulação autonômica cardíaca, sendo a Variabilidade da Frequência cardíaca através do eletrocardiograma a mais utilizada. A manipulação vertebral exerceu influência, na maioria dos artigos, sobre a modulação autonômica cardíaca.Palavras-chave: manipulação da coluna, sistema nervoso autônomo, variabilidade da frequência cardíaca.

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