scholarly journals Assessments of Heart Rate and Sympathetic and Parasympathetic Nervous Activities of Normal Mouse Fetuses at Different Stages of Fetal Development Using Fetal Electrocardiography

2021 ◽  
Vol 12 ◽  
Author(s):  
Yoshiyuki Kasahara ◽  
Chihiro Yoshida ◽  
Masatoshi Saito ◽  
Yoshitaka Kimura
Keyword(s):  
Heart Rate ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Fetal Heart Rate ◽  
Fetal Heart ◽  
Nervous Activity ◽  
Parasympathetic Activity ◽  
Autonomic Nerves ◽  
Autonomic Nervous ◽  
Mouse Fetuses

Heart rate is controlled by the activity of the autonomic nervous system: the sympathetic and parasympathetic nervous systems increase and suppress heart rate, respectively. To evaluate the activity of the autonomic nervous system, it is possible to determine heart rate variability using electrocardiography (ECG). During the fetal period, the heart and autonomic nerves develop in coordination; however, physiological changes, including autonomic nervous activities that occur during the fetal stage, remain largely unknown. Therefore, in this study, we measured ECG signals of mouse fetuses using our established method to evaluate the development of heart rate and autonomic nervous activity at different fetal developmental stages. We found that heart rate was significantly increased in fetal mice at embryonic day (E) 18.5 compared with that at E13.5, E15.5, and E17.5, indicating that fetal heart rate increases only at the stage immediately prior to birth. Interestingly, fetal parasympathetic nervous activity was reduced at E17.5 and E18.5 compared with that at E13.5, whereas fetal sympathetic nervous activity remained unchanged, at least from E13.5 to E18.5. These results indicate that parasympathetic activity rather than sympathetic activity affects fetal heart rate and that the decrease in parasympathetic activity toward the end of pregnancy could result in the observed increase in fetal heart rate.

Fetal monitoring in pregnant women with complicated obstetric history

2017 ◽  
pp. 111-114
Author(s):  
L.I. Vorobey ◽  
Keyword(s):  
Heart Rate ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Pregnant Women ◽  
Functional State ◽  
Fetal Heart Rate ◽  
Fetal Heart ◽  
Autonomic Nervous ◽  
Heart Rate Regulation ◽  
Significant Intensity

The objective: to establish the features of fetus functional state definition in pregnant women with perinatal losses in history. Patients and methods. 89 pregnant women with perinatal losses in history were screened. The fetus functional status evaluation was based on cardiotocography and definition of fetal heart rate variability by cardiointervalography. Results. Received data showed the decrease of SDNN, RMSSD and pNN50 in pregnant women with perinatal losses in history, indicating the prevalence of parasympathetic effects on the fetal myocardium (p<0.05). Studies of mathematical time characteristics of fetal heart rate revealed a significant overweight of the metabolic-humoral regulatory circuit in women with normal pregnancy (p<0.05). Dynamic stress index evaluation indicates the centralization of heart rate regulation and significant intensity of the fetal compensatory mechanisms in pregnant women with perinatal losses in history. The cardiotocography revealed no difference between the fetal status in women of comparative groups (p>0.05). Conclusions. In pregnant women with perinatal losses in history owing to autonomic nervous system disregulation a significant intensity of fetal regulatory systems and the centralization of fetal cardiac rhythm control were observed. The cardiotocography and cardiointervalography data with revealed signs of excessive sympathetic activation can serve as preclinical signs of gestational pathology. Key words: perinatal losses, fetal functional state evaluation, cardiotocography, cardiointervalography, autonomic nervous system.

scholarly journals Differences in the Asymmetry of Beat-to-Beat Fetal Heart Rate Accelerations and Decelerations at Preterm and Term Active Labor

Sensors ◽  
2021 ◽  
Vol 21 (24) ◽  
pp. 8249
Author(s):  
Carolina López-Justo ◽  
Adriana Cristina Pliego-Carrillo ◽  
Claudia Ivette Ledesma-Ramírez ◽  
Hugo Mendieta-Zerón ◽  
Miguel Ángel Peña-Castillo ◽  
...  
Keyword(s):  
Heart Rate ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Fetal Heart Rate ◽  
Fetal Heart ◽  
System Response ◽  
Cardiac Autonomic Nervous System ◽  
Autonomic Nervous ◽  
Active Labor ◽  
The Asymmetry

The fetal autonomic nervous system responds to uterine contractions during active labor as identified by changes in the accelerations and decelerations of fetal heart rate (FHR). Thus, this exploratory study aimed to characterize the asymmetry differences of beat-to-beat FHR accelerations and decelerations in preterm and term fetuses during active labor. In an observational study, we analyzed 10 min of fetal R-R series collected from women during active preterm labor (32–36 weeks of pregnancy, n = 17) and active term labor (38–40 weeks or pregnancy, n = 27). These data were used to calculate the Deceleration Reserve (DR), which is a novel parameter that quantifies the asymmetry of the average acceleration and deceleration capacity of the heart. In addition, relevant multiscale asymmetric indices of FHR were also computed. Lower values of DR, calculated with the input parameters of T = 50 and s = 10, were associated with labor occurring at the preterm condition (p = 0.0131). Multiscale asymmetry indices also confirmed significant (p < 0.05) differences in the asymmetry of FHR. Fetuses during moderate premature labor may experience more decaying R-R trends and a lower magnitude of decelerations compared to term fetuses. These differences of FHR dynamics might be related to the immaturity of the fetal cardiac autonomic nervous system as identified by this system response to the intense uterine activity at active labor.

scholarly journals Developmental milestones of the autonomic nervous system revealed via longitudinal monitoring of fetal heart rate variability

PLoS ONE ◽  
2018 ◽  
Vol 13 (7) ◽  
pp. e0200799 ◽  
Author(s):  
Uwe Schneider ◽  
Franziska Bode ◽  
Alexander Schmidt ◽  
Samuel Nowack ◽  
Anja Rudolph ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Fetal Heart Rate ◽  
Fetal Heart ◽  
Developmental Milestones ◽  
Autonomic Nervous ◽  
Fetal Heart Rate Variability

Effect of Slow and Fast Music on the Autonomic Nervous System and Cardiac Health

2016 ◽  
pp. 198-218 ◽  
Author(s):  
Suraj Kumar Nayak ◽  
Rudra Dutt Shukla ◽  
Ipsita Panda ◽  
Biswajeet Champaty ◽  
Goutam Thakur ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Parasympathetic Activity ◽  
Ecg Signal ◽  
Autonomic Nervous ◽  
Cardiac Health ◽  
Conduction Pathway

In this study, the effect of slow and fast music on the heart rate variability and conduction pathway of the heart was studied. The results indicated an increase in the parasympathetic dominance as the volunteers were made to listen to music. The magnitude of the parasympathetic activity was higher when the volunteers were made to listen to fast music. This indicates that slow and fast music affected the sympatho-vagal balance in different proportions. The analysis of the ECG signal and wavelet transformed ECG signal suggested an alteration in the conduction pathway of the heart.

Abstract 5647: Autonomic Nervous System Dysregulation in Implantable Cardioverter Defibrillator Patients with Depression and Anxiety

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Willem J Kop ◽  
Jennifer L Francis ◽  
Mark C Haigney ◽  
Ali A Weinstein ◽  
Phyllis K Stein ◽  
...  
Keyword(s):  
Heart Rate ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Parasympathetic Activity ◽  
Depression Symptoms ◽  
Implantable Cardioverter Defibrillators ◽  
Depression And Anxiety ◽  
Autonomic Nervous ◽  
Parasympathetic Control ◽  
Artery Disease

Background : Autonomic nervous system (ANS) dysregulation increases risk of ventricular arrhythmias in patients with implantable cardioverter defibrillators (ICD). ANS dysregulation is common in depression and anxiety, but the relationship between these psychological factors and ANS dysregulation has not been investigated in ICD patients. Methods : ANS indices reflecting parasympathetic control of heart rate were obtained using heart rate variability (HRV) analyses in 44 ICD patients with documented coronary artery disease (age 62±9 yrs; ejection fraction 35.9±12.7%). Ambulatory 24-hr ECG recordings were used to calculate HRV (rMSSD and pNN50). Depression was assessed using the Beck Depression Inventory (BDI) and anxiety using the Taylor Manifest Anxiety Scale (TMA). Validated cut-off scores were used (depression: BDI≥10; anxiety: TMa≥9), and data were analyzed using Analysis of Variance. Results : ICD patients with depression symptoms (n=12) had significantly lower HRV markers of ANS parasympathetic activity (rMSSD:15.2±5.7 ms vs. 25.0±13.4 ms, p=0.002; pNN50:1.8±2.7% vs. 5.6±5.7%, p=0.006) than patients with low depression symptoms (n=32). High anxiety (n=10) was related to lower rMSSD (p =0.014). Comorbid depression and anxiety was associated with substantial HRV reduction (p<0.001) (Figure ). Conclusion : Depression and anxiety in ICD patients are associated with autonomic nervous system dysregulation (reduced HRV markers of parasympathetic control). Reduced parasympathetic activity may therefore contribute to the elevated risk of life-threatening cardiac arrhythmias in ICD patients with depression and anxiety. Figure 1. RMSSD among depression/anexity groups

Sign in / Sign up

Export Citation Format

Share Document