scholarly journals Retraction: Lactobacillus gasseri SF1183 Affects Intestinal Epithelial Cell Survival and Growth

PLoS ONE ◽  
2020 ◽  
Vol 15 (3) ◽  
pp. e0230791
Author(s):  
Keyword(s):  
Epithelial Cell ◽  
Cell Survival ◽  
Intestinal Epithelial Cell ◽  
Intestinal Epithelial ◽  
Lactobacillus Gasseri ◽  
Survival And Growth

scholarly journals Lactobacillus gasseri SF1183 Affects Intestinal Epithelial Cell Survival and Growth

PLoS ONE ◽  
2013 ◽  
Vol 8 (7) ◽  
pp. e69102 ◽  
Author(s):  
Blanda Di Luccia ◽  
Nicola Manzo ◽  
Loredana Baccigalupi ◽  
Viola Calabrò ◽  
Elvira Crescenzi ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Cell Survival ◽  
Intestinal Epithelial Cell ◽  
Intestinal Epithelial ◽  
Lactobacillus Gasseri ◽  
Survival And Growth

scholarly journals Soluble Proteins Produced by Probiotic Bacteria Regulate Intestinal Epithelial Cell Survival and Growth

2007 ◽  
Vol 132 (2) ◽  
pp. 562-575 ◽  
Author(s):  
Fang Yan ◽  
Hanwei Cao ◽  
Timothy L. Cover ◽  
Robert Whitehead ◽  
M. Kay Washington ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Cell Survival ◽  
Intestinal Epithelial Cell ◽  
Soluble Proteins ◽  
Probiotic Bacteria ◽  
Intestinal Epithelial ◽  
Survival And Growth

Human intestinal epithelial cell survival: differentiation state-specific control mechanisms

2001 ◽  
Vol 280 (6) ◽  
pp. C1540-C1554 ◽  
Author(s):  
Rémy Gauthier ◽  
Charlène Harnois ◽  
Jean-François Drolet ◽  
John C. Reed ◽  
Anne Vézina ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Cell Survival ◽  
Intestinal Epithelial Cell ◽  
The State ◽  
Control Mechanisms ◽  
Intestinal Epithelial ◽  
Human Intestinal Epithelial Cell ◽  
Expression Levels ◽  
Specific Control

To investigate whether human intestinal epithelial cell survival involves distinct control mechanisms depending on the state of differentiation, we analyzed the in vitro effects of insulin, pharmacological inhibitors of Fak, MEK/Erk, and PI3-K/Akt, and integrin (β1, β4)-blocking antibodies on the survival of the well-established human Caco-2 enterocyte-like and HIEC-6 cryptlike cell models. In addition, relative expression levels of six Bcl-2 homologs (Bcl-2, Bcl-XL, Mcl-1, Bax, Bak, and Bad) and activation levels of Fak, Erk-2, and Akt were analyzed. Herein, we report that 1) the enterocytic differentiation process results in the establishment of distinct profiles of Bcl-2 homolog expression levels, as well as p125Fak, p42Erk-2, and p57Aktactivated levels; 2) the inhibition of Fak, of the MEK/Erk pathway, or of PI3-K, have distinct impacts on enterocytic cell survival in undifferentiated (subconfluent Caco-2, confluent HIEC-6) and differentiated (30 days postconfluent Caco-2) cells; 3) exposure to insulin and the inhibition of Fak, MEK, and PI3-K resulted in differentiation state-distinct modulations in the expression of each Bcl-2 homolog analyzed; and 4) Fak, β1 and β4 integrins, as well as the MEK/Erk and PI3-K/Akt pathways, are distinctively involved in cell survival depending on the state of cell differentiation. Taken together, these data indicate that human intestinal epithelial cell survival is regulated according to differentiation state-specific control mechanisms.

Tu1831 MYPT1 Is a Critical Regulator of Intestinal Epithelial Cell Survival

2016 ◽  
Vol 150 (4) ◽  
pp. S955
Author(s):  
Juanmin Zha ◽  
Weiqi He ◽  
Matthew Odenwald ◽  
Jerrold Turner
Keyword(s):  
Epithelial Cell ◽  
Cell Survival ◽  
Intestinal Epithelial Cell ◽  
Intestinal Epithelial

406 cFLIP Allows Intestinal Epithelial Cell Survival and Immune Homeostasis by Controlling the Activation Level of Caspase8

2013 ◽  
Vol 144 (5) ◽  
pp. S-79
Author(s):  
Nadine Wittkopf ◽  
Claudia Günther ◽  
Eva Martini ◽  
You-Wen He ◽  
Marcus Schuchmann ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Cell Survival ◽  
Intestinal Epithelial Cell ◽  
Immune Homeostasis ◽  
Intestinal Epithelial ◽  
Activation Level

scholarly journals PTBP1/HNRNP I controls intestinal epithelial cell regeneration by maintaining stem cell survival and stemness

2021 ◽  
Author(s):  
Wesley Tung ◽  
Ullas Valiya Chembazhi ◽  
Jing Yang ◽  
Ka Lam Nguyen ◽  
Aryan Lalwani ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Epithelial Cell ◽  
Cell Survival ◽  
Intestinal Epithelial Cell ◽  
Intestinal Stem Cells ◽  
Intestinal Stem Cell ◽  
Cell Regeneration ◽  
Intestinal Epithelial ◽  
Stem Cell Survival

Properly controlled intestinal epithelial cell regeneration is not only vital for protection against insults from environmental hazards but also crucial for preventing intestinal cancer. Intestinal stem cells located in the crypt region provide the driving force for epithelial regeneration, and thus their survival and death must be precisely regulated. We show here that polypyrimidine tract binding protein 1 (PTBP1, also called heterogeneous nuclear ribonucleoprotein I, or HNRNP I), an RNA-binding protein that post-transcriptionally regulates gene expression, is critical for intestinal stem cell survival and stemness. Mechanistically, we show that PTBP1 inhibits the expression of PHLDA3, an AKT repressor, and thereby maintains AKT activity in the intestinal stem cell compartment to promote stem cell survival and proliferation. Furthermore, we show that PTBP1 inhibits the expression of PTBP2, a paralog of PTBP1 that is known to induce neuron differentiation, through repressing inclusion of alternative exon 10 to Ptbp2 transcript. Loss of PTBP1 results in a significant upregulation of PTBP2, which is accompanied by splicing changes in genes that are important for neuron cell development. This finding suggests that PTBP1 prevents aberrant differentiation of intestinal stem cells into neuronal cells through inhibiting PTBP2. Our results thus reveal a novel mechanism whereby PTBP1 maintains intestinal stem cell survival and stemness through the control of gene function post-transcriptionally.

Cellular FLICE-Like Inhibitory Protein Secures Intestinal Epithelial Cell Survival and Immune Homeostasis by Regulating Caspase-8

2013 ◽  
Vol 145 (6) ◽  
pp. 1369-1379 ◽  
Author(s):  
Nadine Wittkopf ◽  
Claudia Günther ◽  
Eva Martini ◽  
Guiwei He ◽  
Kerstin Amann ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Cell Survival ◽  
Intestinal Epithelial Cell ◽  
Immune Homeostasis ◽  
Caspase 8 ◽  
Intestinal Epithelial ◽  
Inhibitory Protein
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