scholarly journals Low transmission of Wuchereria bancrofti in cross-border districts of Côte d’Ivoire: A great step towards lymphatic filariasis elimination in West Africa

PLoS ONE ◽  
2020 ◽  
Vol 15 (4) ◽  
pp. e0231541
Author(s):  
Firmain N. Yokoly ◽  
Julien B. Z. Zahouli ◽  
Aboulaye Méite ◽  
Millicent Opoku ◽  
Bernard L. Kouassi ◽  
...  
Keyword(s):  
West Africa ◽  
Lymphatic Filariasis ◽  
Cote D'ivoire ◽  
Côte D’Ivoire ◽  
Wuchereria Bancrofti ◽  
Cote D’Ivoire ◽  
Low Transmission ◽  
Cross Border ◽  
Côte D'ivoire ◽  
Great Step

scholarly journals Efficacy and Safety of a Single Dose of Ivermectin, Diethylcarbamazine, and Albendazole for Treatment of Lymphatic Filariasis in Côte d’Ivoire: An Open-label Randomized Controlled Trial

2019 ◽  
Vol 71 (7) ◽  
pp. e68-e75 ◽  
Author(s):  
Catherine M Bjerum ◽  
Allassane F Ouattara ◽  
Méité Aboulaye ◽  
Olivier Kouadio ◽  
Vanga K Marius ◽  
...  
Keyword(s):  
Single Dose ◽  
Lymphatic Filariasis ◽  
Cote D'ivoire ◽  
Côte D’Ivoire ◽  
Controlled Trial ◽  
Wuchereria Bancrofti ◽  
Open Label ◽  
Serious Adverse Events ◽  
Cote D’Ivoire ◽  
Côte D'ivoire

Abstract Background Improved drug regimens are needed to accelerate elimination of lymphatic filariasis in Africa. This study determined whether a single co-administered dose of ivermectin plus diethylcarbamazine plus albendazole [IDA] is noninferior to standard 3 annual doses of ivermectin plus albendazole (IA) used in many LF-endemic areas of Africa. Methods Treatment-naive adults with Wuchereria bancrofti microfilaremia in Côte d’Ivoire were randomized to receive a single dose of IDA (n = 43) or 3 annual doses of IA (n = 52) in an open-label, single-blinded trial. The primary endpoint was the proportion of participants who were microfilaria (Mf) negative at 36 months. Secondary endpoints were Mf clearance at 6, 12, and 24 months; inactivation of adult worm nests; and safety. Results At 36 months posttreatment with IDA, 18/33 (55%; 95% CI, 38–72%) cleared Mf versus 33/42 (79%; 67–91%) with IA (P = .045). At 6 and 12 months IDA was superior to IA in clearing Mf (89% [77–99%] and 71% [56–85%]), respectively, versus 34% (20–48%) and 26% (14–42%) (P < .001). IDA was equivalent to IA at 24 months (61% [45–77%] vs 54% [38–72%]; P = .53). IDA was superior to IA for inactivating adult worms at all time points. Both treatments were well tolerated, and there were no serious adverse events. Conclusions A single dose of IDA was superior to 2 doses of IA in reducing the overall Mf burden by 24 months. Reinfection may have contributed to the lack of sustained clearance of Mf with IDA. Clinical Trials Registration NCT02974049.

scholarly journals Exploration targets in the Côte d'Ivoire-Ghana transform margin in Equatorial West Africa

2010 ◽  
Vol 37 (1) ◽  
pp. 43-50 ◽  
Author(s):  
Liu Jianping ◽  
Pan Xiaohua ◽  
Ma Jun ◽  
Tian Zuoji ◽  
Wan Lunkun
Keyword(s):  
West Africa ◽  
Cote D'ivoire ◽  
Côte D’Ivoire ◽  
Cote D’Ivoire ◽  
Côte D'ivoire ◽  
Transform Margin

scholarly journals Tinea Capitis Caused by Microsporum audouninii: A Report of Two Cases from Côte D’Ivoire, West Africa

2021 ◽  
Vol 6 (1) ◽  
pp. 9
Author(s):  
Rie Roselyne Yotsu ◽  
Kouamé Kouadio ◽  
Aubin Yao ◽  
Bamba Vagamon ◽  
Motoi Takenaka ◽  
...  
Keyword(s):  
West Africa ◽  
Dna Sequencing ◽  
Cote D'ivoire ◽  
Tinea Capitis ◽  
Sampling Method ◽  
Côte D’Ivoire ◽  
Adhesive Tape ◽  
Cote D’Ivoire ◽  
Côte D'ivoire ◽  
Epidemiological Surveys

We report here two cases of tinea capitis caused by Microsporum (M.) audouinii in Côte d’Ivoire, West Africa. The patients were a three-year-old boy and a six-year-old girl who presented with scaly patches on the scalp. The causative fungus was isolated using an adhesive tape-sampling method and cultured on Sabouraud dextrose agar plates. It was identified as M. audouinii both by its macroscopic and microscopic features, confirmed by DNA sequencing. These are the first documented cases of M. audouinii infections confirmed with DNA sequencing to be reported from Côte d’Ivoire. The practicality of the tape-sampling method makes it possible to carry out epidemiological surveys evaluating the distribution of these dermatophytic infections in remote, resource-limited settings.

scholarly journals Marching across and beyond West Africa: First record of the stem-galling fly Cecidochares connexa (Diptera: Tephritidae) in Central Africa and the implications for biological control of Chromolaena odorata (Asteraceae)

PLoS ONE ◽  
2021 ◽  
Vol 16 (6) ◽  
pp. e0252770
Author(s):  
Pascal O. Aigbedion-Atalor ◽  
Itohan Idemudia ◽  
Medetissi Adom ◽  
Ethelyn E. Forchibe ◽  
Hospice Tossou ◽  
...  
Keyword(s):  
Biological Control ◽  
West Africa ◽  
Cote D'ivoire ◽  
Côte D’Ivoire ◽  
Biological Control Agent ◽  
Central Africa ◽  
Chromolaena Odorata ◽  
Cote D’Ivoire ◽  
Côte D'ivoire ◽  
Benin Republic

The Neotropical invasive plant Chromolaena odorata R.M. King and H. Robinson (Asteraceae) is a serious weed in West and Central Africa and two biological control agents that have been introduced into West Africa to help reduce its impacts on agriculture and biodiversity, have established. The stem-galling fly, Cecidochares connexa (Macquart) (Diptera: Tephritidae), has spread widely across West Africa since its release in only Côte d’Ivoire, occurring in six countries. This study aimed to investigate whether the gall fly had spread further across West Africa and into Central Africa. Here, we surveyed C. odorata for C. connexa galls in Cameroon between October 2018 and October 2020, along roadsides, on farms, residential areas, and abandoned plots, encompassing various vegetation types. Additional surveys were conducted across four countries (Ghana, Togo, Benin Republic and Nigeria) in West Africa that we considered the probable pathway for the spread of the gall fly into Central Africa. Cecidochares connexa was present at five of the six locations surveyed in Cameroon, albeit in varying abundance. In Africa, these findings represent the first-ever report of C. connexa outside of West Africa. In West Africa, we recorded significant expansion in the geographic range of C. connexa, as reflected in the absent-present record of C. connexa in two locations in Nigeria and one in Ghana, as well as its occurrence in all locations surveyed in Benin Republic and Togo. Clearly, Ghana, Togo, Benin Republic and Nigeria served as the dispersal pathway of C. connexa from the release sites in Côte d’Ivoire into Cameroon, covering over 2,300 km. Following the spread and establishment of C. connexa into Cameroon, we anticipate that it will continue to spread further into other parts of Central Africa which are climatically suitable. Cecidochares connexa is currently the only biological control agent for C. odorata in Central Africa. Given that it has significantly reduced populations of C. odorata in other countries where it has established, it is expected to have a similar impact in Central Africa.

Assessing Anopheles Vector Species Diversity and Transmission of Malaria in Cross-Border Areas of Côte d'Ivoire

2020 ◽  
Author(s):  
Firmain N. Yokoly ◽  
Julien B. Z. Zahouli ◽  
Graham Small ◽  
Allassane F. Ouattara ◽  
Millicent Opoku ◽  
...  
Keyword(s):  
Cote D'ivoire ◽  
Côte D’Ivoire ◽  
Malaria Prevalence ◽  
Vector Species ◽  
Cote D’Ivoire ◽  
Cross Border ◽  
Côte D'ivoire ◽  
Border Areas ◽  
Health Districts ◽  
Sporozoite Infection

Abstract Background Although malaria and Anopheles mosquito vectors are highly prevalent in Côte d'Ivoire, data are still lacking on disease transmission dynamics in cross-border areas. To address this lack of information, we assessed the Anopheles mosquito vector species diversity, the An. gambiae complex members and the transmission of malaria in four cross-border areas of Côte d'Ivoire.Method From July 2016 to December 2017, we collected adult Anopheles mosquitoes in four cross-border health districts of Côte d’Ivoire (Aboisso, Bloléquin, Odienné and Ouangolodougou) using standardized window exit trap (WET) and pyrethrum knockdown spray collection (PSC) methods. We identified collected mosquitoes morphologically at species level and An. gambiae complex members using short interspersed nuclear element-based polymerase chain reaction (SINE-PCR). We analyzed An. gambiae, An. funestus and An. nili specimens for malaria Plasmodium parasite infection using the cytochrome oxidase I gene (COX-I), and malaria prevalence among human population through local Ministry of Health (MoH) statistical yearbooks.Results In total, 281, 754, 1,319 and 2,443 specimens of Anopheles adult females were collected in Aboisso, Bloléquin, Odienné and Ouangolodougou, respectively. We found seven Anopheles species dominated by An. gambiae s.l. (94.8%-99.1%), followed by An. funestus (0.4%-4.3%) and An. nili (0%-0.7%). Among An. gambiae s.l., An. coluzzii predominated in Aboisso (89.2%) and Bloléquin (92.2%), while An. gambiae s.s. was present at the highest frequency in Odienné (96.0%) and Ouangolodougou (94.2%). The Plasmodium sporozoite infection rate in An. gambiae s.l. was highest in Odienné (11.0 %; n = 100) followed by Bloléquin (7.8%, n = 115), Aboisso (3.1%; n = 65) and Ouangologoudou (2.5%; n = 120). In An. funestus, P. falciparum sporozoite infection rate was estimated at 6.2% (n = 32) in Bloléquin, 8.7% (n = 23) in Odienné. No An. funestus specimens were found infected with P. falciparum sporozoite infection in Ouangolodougou and Aboisso. No P. falciparum sporozoite was detected in An. nili specimens in the four health districts. Among the local human populations, malaria prevalence rate was higher in Odienné (39.7%; n = 45,376) and Bloléquin (37.6%; n = 150,205) compared with that in Ouangolodougou (18.3%; n = 131,629) and Aboisso (19.7%; n = 364,585).Conclusion In cross-border health districts of Côte d’Ivoire, Anopheles vector species diversity and abundance and Plasmodium sporozoite infection were high, thus resulting in high transmission of malaria to local populations. An. gambiae and An. funestus were found to be highly Plasmodium-infected in the health districts of Bloléquin and Odienné where malaria prevalence among humans was particularly high. This study provides important information that can be used to guide national malaria control programme strategies in Côte d’Ivoire, mainly in cross-border settings.

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