scholarly journals Mycobacterium tuberculosis universal stress protein Rv2623 interacts with the putative ATP binding cassette (ABC) transporter Rv1747 to regulate mycobacterial growth

2017 ◽  
Vol 13 (7) ◽  
pp. e1006515 ◽  
Author(s):  
Lisa N. Glass ◽  
Ganduri Swapna ◽  
Sivagami Sundaram Chavadi ◽  
JoAnn M. Tufariello ◽  
Kaixia Mi ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Abc Transporter ◽  
Stress Protein ◽  
Atp Binding ◽  
Universal Stress Protein ◽  
Mycobacterial Growth ◽  
Atp Binding Cassette

scholarly journals The human ATP-binding cassette (ABC) transporter superfamily

2001 ◽  
Vol 42 (7) ◽  
pp. 1007-1017 ◽  
Author(s):  
Michael Dean ◽  
Yannick Hamon ◽  
Giovanna Chimini
Keyword(s):  
Abc Transporter ◽  
Atp Binding ◽  
Atp Binding Cassette

scholarly journals Nucleotide-dependent Allostery within the ABC Transporter ATP-binding Cassette

2007 ◽  
Vol 282 (31) ◽  
pp. 22793-22803 ◽  
Author(s):  
Peter M. Jones ◽  
Anthony M. George
Keyword(s):  
Abc Transporter ◽  
Atp Binding ◽  
Atp Binding Cassette

scholarly journals ATP Binding Cassette Transporter A1 is Involved in Extracellular Secretion of Acetylated APE1/Ref-1

2019 ◽  
Vol 20 (13) ◽  
pp. 3178 ◽  
Author(s):  
Yu Ran Lee ◽  
Hee Kyoung Joo ◽  
Eun Ok Lee ◽  
Hyun Sil Cho ◽  
Sunga Choi ◽  
...  
Keyword(s):  
Abc Transporter ◽  
Abc Transporters ◽  
Secretory Pathway ◽  
Trichostatin A ◽  
Atp Binding ◽  
Terminal Protein ◽  
Secretion Signal ◽  
Extracellular Secretion ◽  
Atp Binding Cassette Transporter ◽  
Atp Binding Cassette

Acetylation of nuclear apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE1/Ref-1) is associated with its extracellular secretion, despite the lack of an N-terminal protein secretion signal. In this study, we investigated plasma membrane targeting and translocation of APE1/Ref-1 in HEK293T cells with enhanced acetylation. While APE1/Ref-1 targeting was not affected by inhibition of the endoplasmic reticulum/Golgi-dependent secretion, its secretion was reduced by inhibitors of ATP-binding cassette (ABC) transporters, and siRNA-mediated down-regulation of ABC transporter A1. The association between APE1/Ref-1 and ABCA1 transporter was confirmed by proximal ligation assay and immunoprecipitation experiments. An APE1/Ref-1 construct with mutated acetylation sites (K6/K7R) showed reduced co-localization with ABC transporter A1. Exposure of trichostatin A (TSA) induced the acetylation of APE1/Ref-1, which translocated into membrane fraction. Taken together, acetylation of APE1/Ref-1 is considered to be necessary for its extracellular targeting via non-classical secretory pathway using the ABCA1 transporter.

scholarly journals Cystathionine β-Synthase (CBS) Domains 1 and 2 Fulfill Different Roles in Ionic Strength Sensing of the ATP-binding Cassette (ABC) Transporter OpuA

2011 ◽  
Vol 286 (43) ◽  
pp. 37280-37291 ◽  
Author(s):  
Akira Karasawa ◽  
Guus B. Erkens ◽  
Ronnie P.-A. Berntsson ◽  
Renee Otten ◽  
Gea K. Schuurman-Wolters ◽  
...  
Keyword(s):  
Ionic Strength ◽  
Abc Transporter ◽  
Atp Binding ◽  
Cbs Domains ◽  
Atp Binding Cassette
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