scholarly journals Detection of Thyroid-Stimulating Immunoglobulins by Use of Enzyme-Fragment Complementation

2008 ◽  
Vol 54 (8) ◽  
pp. 1401-1402 ◽  
Author(s):  
Tanya Sandrock ◽  
Alan Terry ◽  
Jeff C Martin ◽  
Evrim Erdogan ◽  
Wayne A Meikle
Keyword(s):  
Thyroid Stimulating Immunoglobulins ◽  
Fragment Complementation

Thyroid Stimulating Immunoglobulins: Measurement and Clinical use

1985 ◽  
Vol 69 (2) ◽  
pp. 113-121 ◽  
Author(s):  
C. A. Ollis ◽  
S. Tomlinson ◽  
D. S. Munro
Keyword(s):  
Thyroid Hormones ◽  
Elevated Serum ◽  
Serum Levels ◽  
The Other ◽  
Graves Disease ◽  
Clinical Use ◽  
Hormone Production ◽  
Skin Changes ◽  
Thyroid Stimulating Immunoglobulins ◽  
Eye Involvement

Graves’ disease is the commonest form of hyperthyroidism in which excessive production of thyroid hormones by the hyperplastic overactive thyroid gland produces elevated serum levels of the thyroid hormones tri-iodothyronine (T3) and thyroxine (T4). Many of the manifestations of Graves’ disease, increased basal metabolic rate, increased heart rate, heat intolerance, sweating and nervousness, can be attributed to the peripheral actions of the excess thyroid hormones. The pathogenesis of many of the other dramatic features of Graves’ disease, such as the eye involvement or localized skin changes, is not fully understood, but circulating immunoglobulins with thyroid stimulating activity are almost certainly linked to excess thyroid hormone production and thereby cause the hyperthyroidism.

scholarly journals Thyroid-stimulating immunoglobulins in neonatal Graves's disease.

1980 ◽  
Vol 55 (11) ◽  
pp. 894-895 ◽  
Author(s):  
C S Teng ◽  
T C Tong ◽  
J H Hutchison ◽  
R T Yeung
Keyword(s):  
Thyroid Stimulating Immunoglobulins

Universal strategies in research and drug discovery based on protein-fragment complementation assays

2007 ◽  
Vol 6 (7) ◽  
pp. 569-582 ◽  
Author(s):  
Stephen W. Michnick ◽  
Po Hien Ear ◽  
Emily N. Manderson ◽  
Ingrid Remy ◽  
Eduard Stefan
Keyword(s):  
Drug Discovery ◽  
Protein Fragment ◽  
Protein Fragment Complementation ◽  
Fragment Complementation
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