Protein Misfolding and Endoplasmic Reticulum Stress in Chronic Lung Disease

CHEST Journal ◽  
2013 ◽  
Vol 143 (4) ◽  
pp. 1098-1105 ◽  
Author(s):  
James Wei ◽  
Sadaf Rahman ◽  
Ehab A. Ayaub ◽  
Jeffrey G. Dickhout ◽  
Kjetil Ask
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Lung Disease ◽  
Chronic Lung Disease ◽  
Protein Misfolding

Protein Misfolding and Endoplasmic Reticulum Stress in Chronic Lung Disease

CHEST Journal ◽  
2020 ◽  
Vol 157 (5) ◽  
pp. 1207-1220 ◽  
Author(s):  
Safaa Naiel ◽  
Victor Tat ◽  
Manreet Padwal ◽  
Megan Vierhout ◽  
Olivia Mekhael ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Lung Disease ◽  
Chronic Lung Disease ◽  
Protein Misfolding

scholarly journals Endoplasmic reticulum stress in lung disease

2017 ◽  
Vol 26 (144) ◽  
pp. 170018 ◽  
Author(s):  
Stefan J. Marciniak
Keyword(s):  
Endoplasmic Reticulum ◽  
Protein Folding ◽  
Pulmonary Fibrosis ◽  
Endoplasmic Reticulum Stress ◽  
Lung Disease ◽  
Cigarette Smoke ◽  
Protein Misfolding ◽  
Fine Particulates ◽  
Disease Protein

Exposure to inhaled pollutants, including fine particulates and cigarette smoke is a major cause of lung disease in Europe. While it is established that inhaled pollutants have devastating effects on the genome, it is now recognised that additional effects on protein folding also drive the development of lung disease. Protein misfolding in the endoplasmic reticulum affects the pathogenesis of many diseases, ranging from pulmonary fibrosis to cancer. It is therefore important to understand how cells respond to endoplasmic reticulum stress and how this affects pulmonary tissues in disease. These insights may offer opportunities to manipulate such endoplasmic reticulum stress pathways and thereby cure lung disease.

IL-10 Promotes Production of Intestinal Mucus by Suppressing Protein Misfolding and Endoplasmic Reticulum Stress in Goblet Cells

2013 ◽  
Vol 144 (2) ◽  
pp. 357-368.e9 ◽  
Author(s):  
Sumaira Z. Hasnain ◽  
Sharyn Tauro ◽  
Indrajit Das ◽  
Hui Tong ◽  
Alice C.–H. Chen ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Protein Misfolding ◽  
Goblet Cells ◽  
Intestinal Mucus

scholarly journals S76 Endoplasmic reticulum stress correlates with fibrosis in interstitial lung disease

Thorax ◽  
2016 ◽  
Vol 71 (Suppl 3) ◽  
pp. A44.3-A45
Author(s):  
H Parfrey ◽  
E Moseley ◽  
B Beardsley ◽  
J Knight ◽  
SJ Marciniak ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Interstitial Lung Disease ◽  
Endoplasmic Reticulum Stress ◽  
Lung Disease

scholarly journals Correction: Prion Protein Misfolding Affects Calcium Homeostasis and Sensitizes Cells to Endoplasmic Reticulum Stress

PLoS ONE ◽  
2022 ◽  
Vol 17 (1) ◽  
pp. e0262628
Author(s):  
Mauricio Torres ◽  
Karen Castillo ◽  
Ricardo Armisén ◽  
Andrés Stutzin ◽  
Claudio Soto ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Prion Protein ◽  
Calcium Homeostasis ◽  
Protein Misfolding

Role of endoplasmic reticulum stress and protein misfolding in disorders of the liver and pancreas

2019 ◽  
Vol 64 (2) ◽  
pp. 315-323 ◽  
Author(s):  
Jan Lukas ◽  
Jola Pospech ◽  
Christina Oppermann ◽  
Christina Hund ◽  
Katharina Iwanov ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Protein Misfolding ◽  
Liver And Pancreas
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