scholarly journals Matrix assisted laser desorption/ionization mass spectrometry imaging method for visualizing spatial distribution of synthetic polymers combining with Kendrick mass defect analysis

2019 ◽  
Vol 26 (2) ◽  
pp. 218-219
Author(s):  
Takaya Satoh ◽  
Yoshihisa Ueda
Keyword(s):  
Mass Spectrometry Imaging ◽  
Laser Desorption ◽  
Synthetic Polymers ◽  
Imaging Method ◽  
Ionization Mass ◽  
Laser Desorption Ionization ◽  
Defect Analysis ◽  
Mass Defect ◽  
Kendrick Mass Defect ◽  
Kendrick Mass Defect Analysis

Convenient Graphical Visualization of Messages Encoded in Sequence-Defined Synthetic Polymers Using Kendrick Mass Defect Analysis of their MS/MS Data

2018 ◽  
Vol 219 (16) ◽  
pp. 1800173 ◽  
Author(s):  
Salomé Poyer ◽  
Thierry Fouquet ◽  
Hiroaki Sato ◽  
Jean-François Lutz ◽  
Laurence Charles
Keyword(s):  
Synthetic Polymers ◽  
Defect Analysis ◽  
Mass Defect ◽  
Graphical Visualization ◽  
Kendrick Mass Defect ◽  
Kendrick Mass Defect Analysis

scholarly journals Diagnosis of Agglomeration and Crystallinity of Active Pharmaceutical Ingredients in Over the Counter Headache Medication by Electrospray Laser Desorption Ionization Mass Spectrometry Imaging

Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 610
Author(s):  
Mariann Inga Van Meter ◽  
Salah M. Khan ◽  
Brynne V. Taulbee-Cotton ◽  
Nathan H. Dimmitt ◽  
Nathan D. Hubbard ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Mass Spectrometry Imaging ◽  
Laser Desorption ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Active Pharmaceutical Ingredients ◽  
Laser Desorption Ionization ◽  
Over The Counter ◽  
Pharmaceutical Ingredients ◽  
Desorption Ionization

Agglomeration of active pharmaceutical ingredients (API) in tablets can lead to decreased bioavailability in some enabling formulations. In a previous study, we determined that crystalline APIs can be detected as agglomeration in tablets formulated with amorphous acetaminophen tablets. Multiple method advancements are presented to better resolve agglomeration caused by crystallinity in standard tablets. In this study, we also evaluate three “budget” over-the-counter headache medications (subsequently labeled as brands A, B, and C) for agglomeration of the three APIs in the formulation: Acetaminophen, aspirin, and caffeine. Electrospray laser desorption ionization mass spectrometry imaging (ELDI-MSI) was used to diagnose agglomeration in the tablets by creating molecular images and observing the spatial distributions of the APIs. Brand A had virtually no agglomeration or clustering of the active ingredients. Brand B had extensive clustering of aspirin and caffeine, but acetaminophen was observed in near equal abundance across the tablet. Brand C also had extensive clustering of aspirin and caffeine, and minor clustering of acetaminophen. These results show that agglomeration with active ingredients in over-the-counter tablets can be simultaneously detected using ELDI-MS imaging.

Ambient Mass Spectrometry Imaging: Plasma Assisted Laser Desorption Ionization Mass Spectrometry Imaging and Its Applications

2014 ◽  
Vol 86 (9) ◽  
pp. 4164-4169 ◽  
Author(s):  
Baosheng Feng ◽  
Jialing Zhang ◽  
Cuilan Chang ◽  
Liping Li ◽  
Min Li ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Mass Spectrometry Imaging ◽  
Laser Desorption ◽  
Ambient Mass Spectrometry ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Laser Desorption Ionization ◽  
Desorption Ionization
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