synthetic polymers
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2022 ◽  
Author(s):  
Hyuna Jo ◽  
Seunghyun Sim

With advances in the field of synthetic biology increasingly allowing us to engineer living cells to perform intricate tasks, incorporating these engineered cells into the design of synthetic polymeric materials will enable programming materials with a wide range of biological functionalities. However, employable strategies for the design of synthetic polymers that form a well-defined interface with living cells and seamlessly integrate their functionalities in materials are still largely limited. Herein, we report the first example of living materials constructed with a dynamic covalent interface between synthetic polymers and living B. subtilis cells. We showedthat 3-acetamidophenylboronic acid (APBA) and polymers of APBA (pAPBA) form dynamic covalent bonds with available diols on the B. subtilis cell surface. Importantly, pAPBA binding to B. subtilis shows a multivalent effect with complete reversibility upon addition of competitive diol species, such as fructose and sorbitol. On the basis of these findings, we constructed telechelic block copolymers with pAPBA chain ends that crosslink B. subtilis cells and produced self- standing living materials. We further demonstrated that the encapsulated cells could be retrieved upon immersing these materials in solutions containing competitive diols and further subjected to biological analyses. This work establishes the groundwork for building a myriad of synthetic polymeric materials integrating engineered living cells and provides a platform for understanding the biology of cells confined within materials.


2022 ◽  
Vol 14 (2) ◽  
pp. 737
Author(s):  
Kamyar Shirvanimoghaddam ◽  
Bożena Czech ◽  
Ram Yadav ◽  
Cemile Gokce ◽  
Laura Fusco ◽  
...  

Coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused a rapidly spreading pandemic and is severely threatening public health globally. The human-to-human transmission route of SARS-CoV-2 is now well established. The reported clinical observations and symptoms of this infection in humans appear in the range between being asymptomatic and severe pneumonia. The virus can be transmitted through aerosols and droplets that are released into the air by a carrier, especially when the person coughs, sneezes, or talks forcefully in a closed environment. As the disease progresses, the use and handling of contaminated personal protective equipment and facemasks have become major issues with significant environmental risks. Therefore, providing an effective method for treating used/contaminated facemasks is crucial. In this paper, we review the environmental challenges and risks associated with the surge in facemask production. We also discuss facemasks and their materials as sources of microplastics and how disposal procedures can potentially lead to the contamination of water resources. We herein review the potential of developing nanomaterial-based antiviral and self-cleaning facemasks. This review discusses these challenges and concludes that the use of sustainable and alternative facemask materials is a promising and viable solution. In this context, it has become essential to address the emerging challenges by developing a new class of facemasks that are effective against the virus, while being biodegradable and sustainable. This paper represents the potentials of natural and/or biodegradable polymers for manufacturing facemasks, such as wood-based polymers, chitosan, and other biodegradable synthetic polymers for achieving sustainability goals during and after pandemics.


Gels ◽  
2022 ◽  
Vol 8 (1) ◽  
pp. 46
Author(s):  
Sihang Liu ◽  
Jingyi Tang ◽  
Fangqin Ji ◽  
Weifeng Lin ◽  
Shengfu Chen

Nonspecific protein adsorption impedes the sustainability of materials in biologically related applications. Such adsorption activates the immune system by quick identification of allogeneic materials and triggers a rejection, resulting in the rapid failure of implant materials and drugs. Antifouling materials have been rapidly developed in the past 20 years, from natural polysaccharides (such as dextran) to synthetic polymers (such as polyethylene glycol, PEG). However, recent studies have shown that traditional antifouling materials, including PEG, still fail to overcome the challenges of a complex human environment. Zwitterionic materials are a class of materials that contain both cationic and anionic groups, with their overall charge being neutral. Compared with PEG materials, zwitterionic materials have much stronger hydration, which is considered the most important factor for antifouling. Among zwitterionic materials, zwitterionic hydrogels have excellent structural stability and controllable regulation capabilities for various biomedical scenarios. Here, we first describe the mechanism and structure of zwitterionic materials. Following the preparation and property of zwitterionic hydrogels, recent advances in zwitterionic hydrogels in various biomedical applications are reviewed.


2022 ◽  
pp. 33-58
Author(s):  
Ibrahim M. Alarifi
Keyword(s):  

2022 ◽  
Author(s):  
Raffael Wolff ◽  
Katharina Ehrmann ◽  
Patrick Knaack ◽  
Konstanze Seidler ◽  
Christian Gorsche ◽  
...  

Bakelite© or phenoplasts are considered the first synthetic polymers in the world. These resins, produced by polycondensation, have always been known for their chemical resistance, excellent flame resistance and thermal...


Polymers ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 121
Author(s):  
Till Krieg ◽  
Cristian Mazzon ◽  
Elena Gómez-Sánchez

Identifying the most vulnerable plastics and monitoring their deterioration is one of the main problems within heritage collections with historical synthetic polymers. Gathering and interpreting data about material and degradation phenomena in a collection reveals its conservation needs. A systematic survey of the collection can help towards this purpose. Surveys aiming at inspecting and documenting damages rely on several tools in order to fulfill their purpose. Firstly, objective descriptions of the damages that may appear, and secondly, the means of acquiring and interpreting material information. To address these needs, this article presents (a) a visual damage catalogue of degradation phenomena in plastic and rubber materials, and (b) the implementation of Fourier-transform infrared spectroscopy (FTIR) and pyrolysis–gas chromatography–mass spectrometry (py-GCMS) for the identification of analytically challenging rubber materials and of blooming phenomena. The damage catalogue is based solely on visual and olfactory signs, so that the assessment is independent of possible causes of damages and underlying processes, with the purpose of allowing objectivity to prime over interpretation. The limitations of the use of FTIR in the identification of heavily compounded rubbers in museum surveys is highlighted, and examples are presented. The use of py-GCMS on these cases conveniently allowed the identification of the constituting monomers of several rubber materials where FTIR could not provide a univocal classification of the material present. The study of several cases of blooming allowed the identification of diverse compositions and origins, showing that the description of a degradation phenomenon is only the first step towards its understanding. Unveiling the nature of a particular case of blooming is particularly critical when conservation treatments, such as the removal of a (potentially protecting) layer, are planned. For this purpose, attenuated total reflection-FTIR (ATR-FTIR) as a surface technique was particularly useful.


2021 ◽  
Vol 12 ◽  
Author(s):  
Nuannuan Li ◽  
Yiying Sun ◽  
Yuanlei Fu ◽  
Kaoxiang Sun

RNA-based therapies have been promising method for treating all kinds of diseases, and four siRNA-based drugs and two mRNA-based drugs have been approved and are on the market now. However, none of them is applied for cancer treatment. This is not only because of the complexity of the tumor microenvironment, but also due to the intrinsic obstacles of RNAs. Until now, all kinds of strategies have been developed to improve the performance of RNAs for cancer therapy, especially the nanoparticle-based ones using biogenic materials. They are much more compatible with less toxicity compared to the ones using synthetic polymers, and the most widely studied biogenic materials are oligonucleotides, exosomes, and cell membranes. Particular characteristics make them show different capacities in internalization and endosomal escape as well as specific targeting. In this paper, we systematically summarize the RNA-based nano-delivery systems using biogenic materials for cancer therapy, and we believe this review will provide a valuable reference for researchers involved in the field of biogenic delivery and RNA-based therapies for cancer treatment.


Biomolecules ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 16
Author(s):  
Jolana Kubíčková ◽  
Tomáš Medek ◽  
Jarmila Husby ◽  
Jana Matonohová ◽  
Hana Vágnerová ◽  
...  

Nonwoven textiles are used extensively in the field of medicine, including wound healing, but these textiles are mostly from conventional nondegradable materials, e.g., cotton or synthetic polymers such as polypropylene. Therefore, we aimed to develop nonwoven textiles from hyaluronan (HA), a biocompatible, biodegradable and nontoxic polysaccharide naturally present in the human body. For this purpose, we used a process based on wet spinning HA into a nonstationary coagulation bath combined with the wet-laid textile technology. The obtained HA nonwoven textiles are soft, flexible and paper like. Their mechanical properties, handling and hydration depend on the microscale fibre structure, which is tuneable by selected process parameters. Cell viability testing on two relevant cell lines (3T3, HaCaT) demonstrated that the textiles are not cytotoxic, while the monocyte activation test ruled out pyrogenicity. Biocompatibility, biodegradability and their high capacity for moisture absorption make HA nonwoven textiles a promising material for applications in the field of wound healing, both for topical and internal use. The beneficial effect of HA in the process of wound healing is well known and the form of a nonwoven textile should enable convenient handling and application to various types of wounds.


Author(s):  
Hindustan Abdul Ahad ◽  
Haranath Chinthaginjala ◽  
Abdalrahman Mohammed Salih Karar ◽  
Musab Idris Mohammed Ali Saeed ◽  
Aladin Khalaf Alla Elhaj Eltahir Alawad

The authors aimed to extend the discharge of Sirolimus from the tablets with a blend of herbal and synthetic polymers. In this study, Sirolimus was taken as a model drug, Hydroxy Propyl Methyl Cellulose as a synthetic polymer and mucilage from Hibiscus rosa sinensis leaves as a natural polymer. Sirolimus is an orphan drug used to treat Lymphangioleiomyomatosis damage and to suppress body refuse towards the transplanted organs. Sirolimus matrix tablets made with the blend of Hibiscus rosa sinensis leaves mucilage and Hydroxy Propyl Methyl Cellulose. The blend was assessed for flow possessions and the designed tablets were categorized for official and non-official tests including Sirolimus discharge. The Sirolimus matrix tablets possess good Sirolimus content with passible pre and post-formulation parameters. The study concludes that there were no chemical interactions between Sirolimus with polymers used. The study also revealed that Hibiscus rosa sinensis leaves mucilage can be a good polymer in grouping with other polymers for prolonged drug discharge.


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