The Role of the Complement System in Innate Immunity

2005 ◽  
Vol 33 (2) ◽  
pp. 103-112 ◽  
Author(s):  
Horea Rus ◽  
Cornelia Cudrici ◽  
Florin Niculescu
Keyword(s):  
Innate Immunity ◽  
Complement System ◽  
The Complement System

scholarly journals Role of Complement in Multiorgan Failure

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Daniel Rittirsch ◽  
Heinz Redl ◽  
Markus Huber-Lang
Keyword(s):  
Immune Response ◽  
Innate Immunity ◽  
Inflammatory Response ◽  
Complement System ◽  
Multiorgan Failure ◽  
Severe Trauma ◽  
Organ Systems ◽  
Activation Products ◽  
The Complement System

Multiorgan failure (MOF) represents the leading cause of death in patients with sepsis and systemic inflammatory response syndrome (SIRS) following severe trauma. The underlying immune response is highly complex and involves activation of the complement system as a crucial entity of innate immunity. Uncontrolled activation of the complement system during sepsis and SIRS with in excessive generation of complement activation products contributes to an ensuing dysfunction of various organ systems. In the present review, mechanisms of the inflammatory response in the development of MOF in sepsis and SIRS with particular focus on the complement system are discussed.

scholarly journals Special Issue: The Role of Complement in Cancer Immunotherapy

Antibodies ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 29
Author(s):  
Ronald P. Taylor
Keyword(s):  
Cancer Immunotherapy ◽  
Complement System ◽  
Immune Defense ◽  
Special Issue ◽  
The Complement System ◽  
Critical Aspects

The complement system plays an important role in critical aspects of immune defense and in the maintenance of homeostasis in the bloodstream, as well as in essentially all tissues and organs [...]

The role of the complement system in hereditary angioedema

2017 ◽  
Vol 89 ◽  
pp. 59-68 ◽  
Author(s):  
Dorottya Csuka ◽  
Nóra Veszeli ◽  
Lilian Varga ◽  
Zoltán Prohászka ◽  
Henriette Farkas
Keyword(s):  
Complement System ◽  
Hereditary Angioedema ◽  
The Complement System

scholarly journals ON VASCULAR STENOSIS, RESTENOSIS AND MANNOSE BINDING LECTIN

2016 ◽  
Vol 29 (1) ◽  
pp. 57-59 ◽  
Author(s):  
Barbara Stadler KAHLOW ◽  
Rodrigo Araldi NERY ◽  
Thelma L SKARE ◽  
Carmen Australia Paredes Marcondes RIBAS ◽  
Gabriela Piovezani Ramos ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Mannose Binding Lectin ◽  
Mannose Binding ◽  
Vascular Stenosis ◽  
Micro Organisms ◽  
The Complement System ◽  
Binding Lectin

Mannose binding lectin is a lectin instrumental in the innate immunity. It recognizes carbohydrate patterns found on the surface of a large number of pathogenic micro-organisms, activating the complement system. However, this protein seems to increase the tissue damage after ischemia. In this paper is reviewed some aspects of harmful role of the mannose binding lectin in ischemia/reperfusion injury.

The role of paramyosin from blood fluke Schistosoma mansoni in inhibition of the complement system

2008 ◽  
Vol 45 (16) ◽  
pp. 4172
Author(s):  
Lina Grekin ◽  
Ram Cohen ◽  
James M. Sodetz ◽  
Daniel Gold ◽  
Zvi Fishelson
Keyword(s):  
Schistosoma Mansoni ◽  
Complement System ◽  
Blood Fluke ◽  
The Complement System

An overview of lipodystrophy and the role of the complement system

2019 ◽  
Vol 112 ◽  
pp. 223-232 ◽  
Author(s):  
F. Corvillo ◽  
B. Akinci
Keyword(s):  
Complement System ◽  
The Complement System

scholarly journals Activation of the complement system by pathogenic fungi.

1996 ◽  
Vol 9 (1) ◽  
pp. 34-46 ◽  
Author(s):  
T R Kozel
Keyword(s):  
Complement System ◽  
Host Resistance ◽  
Molecular Mechanisms ◽  
Fungal Infections ◽  
Pathogenic Fungi ◽  
Complement Cascade ◽  
Experimental Animals ◽  
Molecular Bases ◽  
The Complement System

Fungi have been studied as prototype activators of the complement cascade since the early 1900s. More recently, attention has focused on the role of the complement system in the pathogenesis of fungal infections. The interactions of Cryptococcus neoformans and Candida albicans with the complement system are the most widely characterized; however, all pathogenic fungi examined to date have the ability to initiate the complement cascade. The molecular mechanisms for initiation and regulation of the complement cascade differ from one fungus to another, most likely reflecting differences in the structure of the outer layers of the cell wall. The molecular bases for such differences remain to be identified. Studies of mycoses in experimental animals with induced or congenital deficiencies in the complement system demonstrate that complement is an important innate system for control of fungal infection. Contributions to host resistance include opsonization and generation of inflammatory mediators. Inflammation induced by chemotactic products of the complement system may contribute to the pathogenesis of some fungal infections.

scholarly journals The role of the lectin pathway of the complement system in SARS-CoV-2 lung injury

2020 ◽  
Author(s):  
Mineia Alessandra Scaranello Malaquias ◽  
Ana Carolina Gadotti ◽  
Jarbas da Silva Motta-Junior ◽  
Ana Paula Camargo Martins ◽  
Marina Luise Viola Azevedo ◽  
...  
Keyword(s):  
Lung Injury ◽  
Complement System ◽  
Lectin Pathway ◽  
The Complement System
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