Role of Complement in Multiorgan Failure

Multiorgan failure (MOF) represents the leading cause of death in patients with sepsis and systemic inflammatory response syndrome (SIRS) following severe trauma. The underlying immune response is highly complex and involves activation of the complement system as a crucial entity of innate immunity. Uncontrolled activation of the complement system during sepsis and SIRS with in excessive generation of complement activation products contributes to an ensuing dysfunction of various organ systems. In the present review, mechanisms of the inflammatory response in the development of MOF in sepsis and SIRS with particular focus on the complement system are discussed.

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CD209 (DC-SIGN) – role in the work of the innate immunity and pathogen penetration

Veterinariya, Zootekhniya i Biotekhnologiya ◽

10.36871/vet.zoo.bio.202009007 ◽

2020 ◽

Vol 1 (9) ◽

pp. 64-71

Author(s):

E. A. Klimov ◽

◽

E. K. Novitskaya ◽

S. N. Koval’chuk ◽

◽

...

Keyword(s):

Immune Response ◽

Innate Immunity ◽

Dendritic Cells ◽

Inflammatory Response ◽

Signaling Pathway ◽

Adhesion Molecule ◽

Immune Evasion ◽

Intercellular Adhesion Molecule ◽

Lectin Receptor

Intercellular adhesion molecule CD209 (DC-SIGN) is a membrane C-type lectin receptor expressed on the surface of dendritic cells and macrophages. CD209 plays an important role in innate immunity. Many studies have shown the possibility of interaction of the CD209 molecule with a number of dangerous pathogens of humans and animals. This review summarizes information on the structure of the CD209 gene and its product, describes the role of the CD209 protein in the immune response, in the migration of dendritic cells from the blood to the tissue, and their interaction with neutrophils. The currently known signaling pathway of activation through the CD209 inflammatory response is presented. The role of CD209 as an endocytic antigen receptor and the participation of the protein in immune evasion of pathogens are discussed. The mechanisms known to date for the development of infections caused by pathogens of various nature in animals are described.

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The Role of the Complement System in Innate Immunity

Immunologic Research ◽

10.1385/ir:33:2:103 ◽

2005 ◽

Vol 33 (2) ◽

pp. 103-112 ◽

Cited By ~ 116

Author(s):

Horea Rus ◽

Cornelia Cudrici ◽

Florin Niculescu

Keyword(s):

Innate Immunity ◽

Complement System ◽

The Complement System

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“Eat me” and “don't eat me” signals govern the innate immune response and tissue repair in the CNS: emphasis on the critical role of the complement system

Molecular Immunology ◽

10.1016/s0161-5890(03)00109-3 ◽

2003 ◽

Vol 40 (2-4) ◽

pp. 85-94 ◽

Cited By ~ 123

Author(s):

K Elward

Keyword(s):

Immune Response ◽

Innate Immune Response ◽

Complement System ◽

Tissue Repair ◽

Critical Role ◽

Innate Immune ◽

The Complement System

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A look at the C3 and C5 proteins in the Covid-19

Actualidades Biológicas ◽

10.17533/udea.acbi.v43n115a05 ◽

2021 ◽

Vol 43 (115) ◽

pp. 1-9

Author(s):

Henry David Mosquera-Daza

Keyword(s):

Immune Responses ◽

Complement System ◽

Biological Activities ◽

Multiorgan Failure ◽

Kidney Injury ◽

First Line ◽

Global Pandemic ◽

Acute Injuries ◽

The Complement System

The emergency caused by the new SARS-CoV-2 virus, which causes the Covid-19 disease, has triggered a global pandemic. One of the most characteristic factors of SARS-CoV-2 virus infection is the deregulated activation of the complement system, especially by proteins C3 and C5. These proteins trigger initiation reactions such as maintenance of inappropriate biological activities in addition to uncontrolled immune responses by immune cells, especially neutrophils. They generate various pathologies such as acute stroke, heart attack, coagulopathies, multiorgan failure, inflammation, immunothrombinosis, heart failure, acute kidney injury, acute injuries in the lung area, thrombotic microangiopathy, pneumonia, and dysfunctional immune responses. Because of the crucial role played by proteins C3 and C5 in the infection by the SARS-COV-2 virus, new complement system inhibition treatments have emerged as a possible first line of defense against the worst symptoms developed during Covid-19 disease. This article will review in a general way, the role of C3 and C5 proteins and the treatments aimed at the inhibition of these same proteins during SARS-CoV-2 infection.

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Targeting the complement system in bacterial meningitis

Brain ◽

10.1093/brain/awz222 ◽

2019 ◽

Vol 142 (11) ◽

pp. 3325-3337 ◽

Cited By ~ 7

Author(s):

Diederik L H Koelman ◽

Matthijs C Brouwer ◽

Diederik van de Beek

Keyword(s):

Bacterial Meningitis ◽

Inflammatory Response ◽

Complement System ◽

Morbidity And Mortality ◽

Treatment Target ◽

Anaphylatoxin C5a ◽

Promising Treatment ◽

The Complement System ◽

Host Inflammatory Response

Morbidity and mortality in bacterial meningitis are driven by an uncontrolled host inflammatory response. Koelman et al. evaluate the detrimental role of the complement system in spurring this inflammation, and conclude that anaphylatoxin C5a is a promising treatment target in bacterial meningitis.

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Special Issue: The Role of Complement in Cancer Immunotherapy

Antibodies ◽

10.3390/antib10030029 ◽

2021 ◽

Vol 10 (3) ◽

pp. 29

Author(s):

Ronald P. Taylor

Keyword(s):

Cancer Immunotherapy ◽

Complement System ◽

Immune Defense ◽

Special Issue ◽

The Complement System ◽

Critical Aspects

The complement system plays an important role in critical aspects of immune defense and in the maintenance of homeostasis in the bloodstream, as well as in essentially all tissues and organs [...]

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The role of the complement system in hereditary angioedema

Molecular Immunology ◽

10.1016/j.molimm.2017.05.020 ◽

2017 ◽

Vol 89 ◽

pp. 59-68 ◽

Cited By ~ 19

Author(s):

Dorottya Csuka ◽

Nóra Veszeli ◽

Lilian Varga ◽

Zoltán Prohászka ◽

Henriette Farkas

Keyword(s):

Complement System ◽

Hereditary Angioedema ◽

The Complement System

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Role of the Complement System in the Acute Respiratory Effects of Inhaled Endotoxin and Cotton Dust

Inhalation Toxicology ◽

10.3109/08958379408995235 ◽

1994 ◽

Vol 6 (3) ◽

pp. 253-266 ◽

Cited By ~ 1

Author(s):

Terry Gordon

Keyword(s):

Complement System ◽

Cotton Dust ◽

Respiratory Effects ◽

The Complement System

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ON VASCULAR STENOSIS, RESTENOSIS AND MANNOSE BINDING LECTIN

ABCD Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) ◽

10.1590/0102-6720201600010015 ◽

2016 ◽

Vol 29 (1) ◽

pp. 57-59 ◽

Cited By ~ 1

Author(s):

Barbara Stadler KAHLOW ◽

Rodrigo Araldi NERY ◽

Thelma L SKARE ◽

Carmen Australia Paredes Marcondes RIBAS ◽

Gabriela Piovezani Ramos ◽

...

Keyword(s):

Innate Immunity ◽

Ischemia Reperfusion Injury ◽

Ischemia Reperfusion ◽

Mannose Binding Lectin ◽

Mannose Binding ◽

Vascular Stenosis ◽

Micro Organisms ◽

The Complement System ◽

Binding Lectin

Mannose binding lectin is a lectin instrumental in the innate immunity. It recognizes carbohydrate patterns found on the surface of a large number of pathogenic micro-organisms, activating the complement system. However, this protein seems to increase the tissue damage after ischemia. In this paper is reviewed some aspects of harmful role of the mannose binding lectin in ischemia/reperfusion injury.

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