The effectiveness of chloroquine compared to Fansidar in treating falciparum malaria

Background The most difficult problem in eradicating malaria isthe resistance of P. falciparum to drugs. Mandailing Natal has thehighest malaria incidence in North Sumatera.Objective This study aimed to investigate the efficacy of chloro-quine and Fansidar in treating falciparum malaria.Methods A randomized double-blind study was done from April toMay 2001. Eighty-three patients with acute uncomplicated P.falciparum malaria infection were randomized into two groups.Group I (35 patients) received chloroquine and group II (48 pa-tients) received Fansidar. Blood examinations were performed onthe 1 st , 2 nd , 7 th , and 28 th days.Results The resistance of P. falciparum to drugs in the chloro-quine group were found in 10 patients with R II and 1 patients withR III, while in the Fansidar group, there were 14 patients with R II.Conclusion The efficacy of chloroquine and Fansidar in treatingfalciparum malaria was not significantly different

Download Full-text

A randomized, double-blind study on the efficacy and safety of a practical three-day regimen with artesunate and mefloquine for the treatment of uncomplicated Plasmodium falciparum malaria in Africa

Transactions of the Royal Society of Tropical Medicine and Hygiene ◽

10.1016/s0035-9203(02)90344-5 ◽

2002 ◽

Vol 96 (6) ◽

pp. 655-659 ◽

Cited By ~ 17

Author(s):

A. Massougbodji ◽

M. Kone ◽

D. Kinde-Gazard ◽

A. Same-Ekobo ◽

N. Cambon ◽

...

Keyword(s):

Plasmodium Falciparum ◽

Falciparum Malaria ◽

Plasmodium Falciparum Malaria ◽

Blind Study ◽

Double Blind Study ◽

Efficacy And Safety ◽

Double Blind ◽

Uncomplicated Plasmodium Falciparum Malaria

Download Full-text

Artesunate and mefloquine given simultaneously for three days via a prepacked blister is equally effective and tolerated as a standard sequential treatment of uncomplicated acute Plasmodium falciparum malaria: randomized, double-blind study in Thailand.

American Journal of Tropical Medicine and Hygiene ◽

10.4269/ajtmh.2002.67.465 ◽

2002 ◽

Vol 67 (5) ◽

pp. 465-472 ◽

Cited By ~ 18

Author(s):

S Krudsood ◽

E A Mueller ◽

S Looareesuwan ◽

U Silachamroon ◽

K Chalermrut ◽

...

Keyword(s):

Plasmodium Falciparum ◽

Falciparum Malaria ◽

Plasmodium Falciparum Malaria ◽

Sequential Treatment ◽

Blind Study ◽

Double Blind Study ◽

Double Blind

Download Full-text

COMPARISON OF TWO DIFFERENT DOSES OF ORAL MIDAZOLAM PREMEDICATION ON INDUCTION DOSE AND CHARACTERISTICS OF PROPOFOL: A DOUBLE BLIND STUDY

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v5i8.2079 ◽

2021 ◽

Vol 5 (8) ◽

Author(s):

Mukesh Choudhary ◽

Neeti Mahla

Keyword(s):

Water Soluble ◽

Blind Study ◽

Double Blind Study ◽

Double Blind ◽

Induction Dose ◽

Group I ◽

Oral Midazolam ◽

Group Ii ◽

Different Doses ◽

Midazolam Premedication

Background: Midazolam is a water-soluble, short acting benzodiazepine. The objective of our study was to study the effect of two different doses of oral midazolam premedication on propofol induction dose and characteristics. Methods: Randomized, prospective, double blind study conducted on 100 ASA I and II patients, falling between the age group of 18-60 yrs were randomly divided in to two groups, group I and group II, who received 7.5mg and 15mg midazolam orally 45 mins before the surgery respectively. Results: Mean time taken for induction in group-A was significantly higher in group-I as compare to group-II. No significant difference was noted with respect to degree of sedation, changes in the heart rate and means arterial pressure, oxygen saturation between the two groups. Conclusion: Our study concluded that 15mg midazolam premedication offers more benefits than 7.5mg midazolam by reducing induction dose of propofol without any undesirable effects like excess sedation, bradycardia and hypotension. Keywords: Midazolam, Induction, Premedication

Download Full-text