COMPARISON OF TWO DIFFERENT DOSES OF ORAL MIDAZOLAM PREMEDICATION ON INDUCTION DOSE AND CHARACTERISTICS OF PROPOFOL: A DOUBLE BLIND STUDY

Background: Midazolam is a water-soluble, short acting benzodiazepine. The objective of our study was to study the effect of two different doses of oral midazolam premedication on propofol induction dose and characteristics. Methods: Randomized, prospective, double blind study conducted on 100 ASA I and II patients, falling between the age group of 18-60 yrs were randomly divided in to two groups, group I and group II, who received 7.5mg and 15mg midazolam orally 45 mins before the surgery respectively. Results: Mean time taken for induction in group-A was significantly higher in group-I as compare to group-II. No significant difference was noted with respect to degree of sedation, changes in the heart rate and means arterial pressure, oxygen saturation between the two groups. Conclusion: Our study concluded that 15mg midazolam premedication offers more benefits than 7.5mg midazolam by reducing induction dose of propofol without any undesirable effects like excess sedation, bradycardia and hypotension. Keywords: Midazolam, Induction, Premedication

The Effect Of Halothane On Number Of The Gad65/67 Positive Cells In Rat Hippocampus At The Midazolam Premedication

The experimental results of halothane effect on GAD65/67 positive cells, number in ÑÀ1 and ÑÀ1 fields of white rat hippocampus are presented in the proposed work. It has been shown, that the number of GAD65/67 positive cells are decreased in CA3 field of hippocampus after 24 hours of halothane anesthesia. Simultaneously the number of the same cells are increased in CA1 field of hippocampus. Midazolam premedication promotes normalization of activity of GAD65/67 which is substantiated by increased number of GAD65/67 positive cells in CA3 field of rat hippocampus after 24 hours.