scholarly journals Peran Reticulocyte Hemoglobin Content (Ret-He) dalam Mendeteksi Defisiensi Besi pada Anak

Sari Pediatri ◽  
2019 ◽  
Vol 20 (5) ◽  
pp. 316
Author(s):  
Ika Maya Sandy ◽  
Murti Andriastuti
Keyword(s):  
Iron Deficiency ◽  
Binding Capacity ◽  
Total Iron ◽  
Google Scholar ◽  
Iron Binding ◽  
Total Iron Binding Capacity ◽  
Hemoglobin Content ◽  
Level Of Evidence ◽  
Iron Binding Capacity ◽  
Reticulocyte Hemoglobin Content

Latar belakang. Defiseinsi besi (DB) didefinisikan sebagai penurunan total kandungan besi dalam tubuh yang ditandai dengan turunnya kadar feritin atau saturasi transferin. Gangguan perkembangan neurokognitif yang timbul akibat DB bersifat permanen. Identifikasi adanya DB penting untuk memulai terapi besi untuk mencegah komplikasi jangka panjang.Tujuan. Mengetahui peran Ret-He dalam mendeteksi DB pada anak dibandingkan dengan pemeriksaan biomarker penanda status besi lain (feritin, saturasi transferin, kadar besi serum, dan total iron binding capacity (TIBC)).Metode. Penelusuran pustaka database elektronik, yaitu Pubmed, Cochrane, ProQuest dan Google scholar dengan kata kunci “iron deficiency”, “AND” “reticulocyte hemoglobin  content”, “AND” “children”.Hasil. Penelusuran literatur diperoleh 4 artikel yang terpilih kemudian dilakukan telaah kritis. Studi oleh Mateos dkk, dengan level of evidence 1c, diperoleh nilai cut-off: ≤ 25 pg, memiliki sensitivitas tertinggi dibanding studi lainnya, yaitu 94% dan spesifisitas 80%, NDP 54%, NDN 97%. Studi lain menentukan nilai cut-off yang berbeda-beda sehingga mempengaruhi nilai sensitivitas, spesifisitas, nilai duga positif dan negatif.Kesimpulan. Berdasarkan penelitian ilmiah yang telah dipaparkan dapat disimpulkan bahwa Ret-He dapat digunakan sebagai parameter untuk mendeteksi DB pada anak.

Serum iron and total iron-binding capacity compared with serum ferritin in assessment of iron deficiency.

1981 ◽  
Vol 27 (2) ◽  
pp. 276-279 ◽  
Author(s):  
F Peter ◽  
S Wang
Keyword(s):  
Iron Deficiency ◽  
Serum Ferritin ◽  
Serum Iron ◽  
Binding Capacity ◽  
Transferrin Saturation ◽  
Total Iron ◽  
Iron Binding ◽  
Total Iron Binding Capacity ◽  
Iron Deficient ◽  
Iron Binding Capacity

Abstract Ferritin values for 250 selected sera were compared with values for iron, total iron-binding capacity (TIBC), and transferrin saturation, to assess the potential of the ferritin assay for the detection of latent iron deficiency. The specimens were grouped (50 in each group) according to their values for iron and TIBC. In Group 1 (low iron, high TIBC) the saturation and ferritin values both indicated iron deficiency in all but one. In the 100 specimens of Groups 2 (normal iron, high TIBC) and 4 (normal iron, high normal TIBC), the saturation values revealed 16 iron-deficient cases, the ferritin test 55. For Groups 3 (low iron, normal TIBC) and 5 (low iron, low TIBC), the ferritin test revealed fewer cases of iron deficiency than did the saturation values (37 cases vs 51 cases, in the 100 specimens). Evidently the ferritin test detects iron deficiency in many cases for whom the serum iron and TIBC tests are not positively indicative. The correlation of serum ferritin with iron, TIBC, and transferrin saturation in the five groups was good only in the case of specimens for which the TIBC was normal; if it was abnormal the correlation was very poor.

Immunological Measurement of Transferrin Compared with Chemical Measurement of Total Iron-Binding Capacity

1975 ◽  
Vol 21 (8) ◽  
pp. 1063-1066 ◽  
Author(s):  
Swei H Tsung ◽  
Waldemar A Rosenthal ◽  
Karen A Milewski
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Binding Capacity ◽  
Total Iron ◽  
Deficiency Anemia ◽  
Iron Binding ◽  
Total Iron Binding Capacity ◽  
Chronic Disorders ◽  
Birth Control Pills ◽  
Iron Binding Capacity

Abstract Because of uncertainty as to the molecular weight of transferrin, a previous comparison [Von der Heul et al., Clin. Chim. Acta 38, 347 (1972)] between transferrin content of serum and total iron-binding capacity cannot be definitive. We found a conversion factor for expressing transferrin as iron-binding capacity by measuring the maximum amount of iron bound by 1 mg of transferrin. We compared the resulting calculated value with values obtained by three other methods for measuring total iron-binding capacity. We agree with the previous observation that the latter, as measured radioisotopically, give higher results than would be judged from the transferrin content but the same as those for two chemical methods. The diffusion rate of transferrin in agar was the same irrespective of the degree of iron saturation. Serum transferrin concentrations were low in patients with anemia resulting from malignancy, chronic disorders, and cirrhosis of the liver, and high or normal in patients with iron deficiency anemia and in pregnant women or women who were taking birth-control pills. Measurement of transferrin concentration can be used to distinguish iron deficiency anemia from anemia resulting from chronic disorders, but offers no advantages over existing methods for estimating total ironbinding capacity.

scholarly journals Saliva and Serum Ghrelin and Obestatin in Iron Deficiency Anemia Patients

2018 ◽  
Author(s):  
Kader Ugur ◽  
Suleyman Aydin ◽  
Emir Donder ◽  
İbrahim Sahin ◽  
Meltem Yardim ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Binding Capacity ◽  
Total Iron ◽  
Deficiency Anemia ◽  
Iron Binding ◽  
Total Iron Binding Capacity ◽  
Iron Treatment ◽  
Iron Binding Capacity ◽  
Serum Ghrelin

Ghrelin and obestatin, two antagonist peptide hormones, are purportedly involved in stimulating appetite and controlling energy balance in humans. Serum ghrelin level is also associated with iron deficiency anemia (IDA), but no study has yet been made of the obestatin level in patients with IDA, even though both hormones are a single gene product. Therefore, the purpose of this investigation is to see whether there is a link between IDA and these two hormones among other hematological parameters in patients with IDA. To measure ghrelin and obestatin, human saliva and serum were collected from 30 women with IDA, aged 31.7 ± 10.7 years, and 30 control women, aged 30.2 ± 8.0 years, with repeated collection of samples over a period of 1 week and 1 month. Saliva and serum ghrelin levels were measured by ELISA. Serum hemoglobin, ferritin, hematocrit and total iron-binding capacity (TIBC) values were determined with an Olympus AU2700.  Saliva and serum ghrelin and obestatin levels were significantly lower in the IDA group compared with controls; these levels increased slightly above baseline with iron treatment, but remained below the control values. Furthermore, and as expected, serum hemoglobin, ferritin, and hematocrit levels were significantly increased with iron treatment, while total iron-binding capacity decreased compared to baseline concentrations. The findings suggest that IDA might be linked to imbalance of circulating (serum) and non-circulating (saliva) ghrelin and obestatin levels. Decreased ghrelin and obestatin might destroy iron homeostasis through its effect on intestinal absorption. Measuring these hormone levels might be useful for monitoring the response to iron treatment. Also, serum and saliva levels for both hormones were well correlated. Thus, using saliva in place of serum for monitoring the two hormones should minimize inconvenience and patient discomfort.

The Assessment of Iron Deficiency in Pregnancy

1969 ◽  
Vol 14 (6) ◽  
pp. 209-214 ◽  
Author(s):  
J. Bonnar ◽  
A. Goldberg
Keyword(s):  
Iron Deficiency ◽  
Haemoglobin Level ◽  
Early Pregnancy ◽  
Binding Capacity ◽  
Total Iron ◽  
Iron Binding ◽  
Total Iron Binding Capacity ◽  
Not Given ◽  
Iron Binding Capacity ◽  
In Pregnancy

Serial observations were made on two groups of women from early pregnancy to term to assess the effect of pregnancy on the iron status. The first group had no evidence of iron deficiency in early pregnancy and were not given supplementary iron. The second group of patients were a random selection and each patient was given a regular supply of iron tablets. The cooperation of the patient in taking the iron was verified by stool tests. The measurements of the serum iron, total iron binding capacity (transferrin), and erythrocyte porphyrins in addition to the other haematological investigations indicated that in the patients not given iron and those who did not take the supplementary iron the haemoglobin level gradually decreased, and iron deficiency was present. In the patients regularly taking supplementary iron the haemoglobin level was over 12 g. per 100 ml. at term, and the biochemical findings showed no evidence of iron deficiency. The total iron-binding capacity gradually increased during pregnancy with and without iron deficiency. Red cell morphology and the mean haemoglobin concentration were not sensitive indices of iron deficiency. The results of the study suggest that ‘physiological’ anaemia does not exist in pregnancy and reduced haemoglobin values in late pregnancy are most likely the result of an inadequate iron intake.

scholarly journals Studying anemia of chronic disease and iron deficiency in patients with rheumatoid arthritis by iron status and circulating hepcidin

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Warqaa Khalaf ◽  
Haithem Ahmed Al-Rubaie ◽  
Sami Shihab
Keyword(s):  
Rheumatoid Arthritis ◽  
Iron Deficiency ◽  
Serum Iron ◽  
Binding Capacity ◽  
Total Iron ◽  
Iron Binding ◽  
Total Iron Binding Capacity ◽  
Anemia Of Chronic Disease ◽  
Serum Hepcidin ◽  
Iron Binding Capacity

Anemia of chronic disease (ACD) and iron deficiency anemia (IDA) are the two most important types of anemia in rheumatoid arthritis (RA). Functional iron deficiency in ACD can be attributed to overexpression of the main iron regulatory hormone hepcidin leading to diversion of iron from the circulation into storage sites resulting in iron-restricted erythropoiesis. The aim is to investigate the role of circulating hepcidin and to uncover the frequency of IDA in RA. The study included 51 patients with RA. Complete blood counts, serum iron, total iron binding capacity, ferritin, and hepcidin- 25 were assessed. ACD was found in 37.3% of patients, IDA in 11.8%, and combined (ACD/IDA) in 17.6%. Serum hepcidin was higher in ACD than in control and the other groups (P≤0.001). It was strongly and positively correlated with ferritin (P<0.001), while hemoglobin, serum iron, and total iron binding capacity were negatively correlated with hepcidin (P=0.016, 0.022 and <0.001, respectively). High serum hepcidin was significantly associated with ACD in RA. IDA alone or combined with ACD was encountered in about a third of patients.

scholarly journals Iron Deficiency, Ferritin and Total Iron Binding Capacity Among Bangladeshi Children: Urban and Rural Settings

2020 ◽  
Vol 4 (2) ◽  
pp. 01-05
Author(s):  
Swapan Kumar Chowdhury ◽  
Shafi Ahmed ◽  
Palash Chandra Banik ◽  
Poly Immaculata Costa ◽  
Rabeya Yasmin ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Binding Capacity ◽  
Total Iron ◽  
Iron Binding ◽  
Total Iron Binding Capacity ◽  
Rural Settings ◽  
Iron Binding Capacity
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