scholarly journals Profil Klinis dan Laboratoris Infeksi Sitomegalovirus Kongenital di Rumah Sakit Umum Pusat Dr. Sardjito

Sari Pediatri ◽  
2021 ◽  
Vol 22 (5) ◽  
pp. 297
Author(s):  
Ruth Kania Permatasari ◽  
Agung Triono ◽  
Eggi Arguni

Latar belakang. Sitomegalovirus (Cytomegalovirus/CMV) kongenital merupakan infeksi yang menimbulkan beban kesehatan yang berat bagi anak dan keluarga. Manifestasi infeksi CMV kongenital, antara lain, jaundice, trombositopenia, mikrosefali dan kalsifikasi intrakranial. Di Indonesia, data mengenai profil klinis dan laboratoris infeksi CMV kongenital belum banyak dilaporkan, terutama di RSUP Dr. Sardjito, Yogyakarta. Tujuan. Mengetahui profil klinis dan laboratoris infeksi CMV kongenital pada pasien anak di RSUP Dr. Sardjito.Metode. Penelitian observasional ini dilakukan dengan melihat rekam medis pasien usia kurang dari 2 tahun dengan infeksi CMV kongenital, yang dirawat inap di RSUP Dr. Sardjito dari Januari 2012 sampai Juli 2017. Hasil. Selama periode penelitian terdapat 36 pasien dengan infeksi CMV kongenital. Manifestasi klinis yang paling mendominasi adalah tetraparesis spastik (12,5%), mikrosefali (25,81%), hepatomegali (22,86%), sensory neural hearing loss (SNHL) (23,81%), atrofi cerebri (40,00%), dan kalsifikasi intrakranial (72,73%). Manifestasi laboratoris ditemukan IgG positif 100%, IgM positif 30,30%, antigenemia positif 100%, anemia 50,00%, neutropenia 40,00%, peningkatan SGPT 61,11%, dan bilirubinemia 75,00%. Kesimpulan. Manifestasi klinis berdasarkan pemeriksaan klinis yang paling banyak ditemui adalah mikrosefali dan manifestasi laboratoris yang paling banyak ditemui adalah IgG positif dan antigenemia positif.

1967 ◽  
Vol 70 (4) ◽  
pp. 621-623 ◽  
Author(s):  
Geoffrey C. Robinson ◽  
Margaret M. Johnston

2020 ◽  
Vol 42 (3) ◽  
pp. 38-41
Author(s):  
Yogesh Neupane ◽  
Bijaya Kharel ◽  
Heempali Dutta

Introduction Incidence of sensory neural hearing loss following mastoid surgery varies from 1.2 – 4.5%.There are various causes for postoperative sensorineural hearing loss during mastoid surgery. This study aims to identify whether there is any correlation between drilling and postoperative sensory neural hearing loss. MethodsA retrospective study was conducted in the Department of ENT from January 2018 to June 2019. A total number of 68 patients above five years of age who underwent modified radical mastoidectomy for chronic otitis media squamous were included. Revision surgery, preoperative sensorineural hearing loss, injury to the ossicular chain during surgery, patients with lack of follow up or doubtful reports in mentally challenged were excluded from the study. The average bone conduction threshold was calculated from 500, 1000, 2000, 4000 Hz and compared using the Wilcoxon signed-rank test. ResultsThere were 43 males and 25 females in the study with a median age of 23.5 years (16-55). The mean preoperative bone conduction threshold in the four frequencies of 500 Hz, 1kHz, 2kHz, 4kHz were -2.06dB, -2.06dB, 3.31dB, 4.63 dB respectively and the mean postoperative bone conduction thresholds were 1.03, 1.32, 5.29, 4.04 respectively. There was a decline of mean of 3.09 dB and 3.38dB only at the low-frequencies (500Hz and 1kHz) BC threshold respectively which were statistically significant, whereas at higher frequency there was no decline in average postoperative BC threshold. ConclusionThere is no definite role of drill in inducing hearing loss and if present other causes of hearing loss should be sought in postoperative sensorineural hearing loss.


1986 ◽  
Vol 95 (3_part_1) ◽  
pp. 344-346 ◽  
Author(s):  
G. Joseph Parell ◽  
Gary D. Becker

In patients who are thought to have a perilymph (PL) fistula, careful inspection of the round and oval windows during exploratory tympanotomy may be normal. The decision must then be made either to terminate the procedure—knowing that the patient's symptoms will probably continue or deteriorate—or to repair both windows as if PL fistulas were present, risking further damage to the inner ear. From a series of 14 patients explored for possible PL fistulas, we report on 6 patients with preoperative diagnoses of PL fistula, based on history, physical examination, and audiometry. Symptoms resulting from trauma were present from 10 days to 23 years before surgery. During exploratory tympanotomy, no fistulas were evident; however, both the oval and round windows were repaired with tissue grafts. Follow up—for 1 to 5 years—revealed that vertigo was relieved in all patients. Postoperatively, one patient had a mild conductive hearing loss; yet no patient sustained a sensory neural hearing loss. We conclude that patch grafting of both the oval and round windows is a safe and effective method of treating suspected, but inapparent fistulas. Patient selection, surgical technique, and results shall be detailed.


2017 ◽  
Vol 5 (1) ◽  
pp. 8-11
Author(s):  
Dipendra Gautam ◽  
D. Paudel ◽  
S. Thapa ◽  
S.K. Sharma

Objectives: To correlate the hearing loss with duration of the disease, stage of the disease, ototoxic drugs use, co-morbidity and biochemical parameters in patients with chronic kidney disease (CKD).Material and Methods: This prospective study of 50 CKD patients was conducted in the department of ototolaryngology head and neck surgery and department of internal medicine, B. P. Koirala Institute of Health Sciences, Dharan, between December 2008 to November 2009. The blood investigation report of the patients were noted. Otological examination was carried out including tunning fork test and pure tone audiometry. Middle ear pathology and conductive hearing loss were excluded. Data was collected and analyzed.Results : Sensory neural hearing loss was higher in patients with; end stage renal disease (stage-5), co-morbidity, haemoglobin level less than 8.5, duration of CKD greater than 2 years, and ototoxic drug administration, but not statistically significant (P-value >0.05). Hearing loss in patients with CKD was not influenced by fasting blood sugar, serum urea, creatinine, sodium, potassium, calcium and serum phosphorus. (P-value >0.05)Conclusion: The hearing loss in patients with chronic kidney disease was not significantly related with stage of CKD, co-morbidity, ototoxic drug use, fasting blood sugar, serum urea, creatinine, sodium, potassium, calcium and serum phosphorus (P-value >0.05). The sensory neural hearing loss in these patients may be due to the advanced age and possible accelerated presbyacusis by the disease.  


1979 ◽  
Vol 51 (6) ◽  
pp. 860-861 ◽  
Author(s):  
George B. Jacobs ◽  
Joel F. Lehrer ◽  
Robert C. Rubin ◽  
John H. Hubbard ◽  
Donald J. Nalebuff ◽  
...  

✓ Posttraumatic vertigo may be an accompanying symptom associated with concussion and with the post-concussion state. It is possible, however, that these symptoms are related to perilymphatic fistulas and are not the direct result of cerebral concussion. Although many fistulae heal spontaneously, patients with persistent vertigo and fluctuating hearing loss following head trauma may have associated defects in the perilymphatic channels with fistulas in the region of the oval or round windows. This paper presents results of surgical repair in three patients with fistulas. Surgical intervention becomes much more urgent when sensory neural hearing loss has occurred acutely or has developed during the course of illness.


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