Over-The-Counter Drugs at Convenience Stores - Safety Issues and Legal Alternatives -

2018 ◽  
Vol 14 (8) ◽  
pp. 57-72
Author(s):  
Hae Jin Yoon ◽  
◽  
Soon Koo Myoung
Keyword(s):  
Over The Counter ◽  
Safety Issues ◽  
Convenience Stores

Over-the-Counter Monograph Safety, Innovation, and Reform Act

2021 ◽  
Vol 49 (2) ◽  
pp. 321-327
Author(s):  
Jason Gardiner ◽  
Aaron S. Kesselheim
Keyword(s):  
Over The Counter ◽  
Safety Issues ◽  
Otc Drugs ◽  
The Us

AbstractOver-the-counter (OTC) drugs are ubiquitous in the US. Policymakers have long debated how to modernize the system for making determinations of safety and effectiveness and addressing safety issues with OTC drugs.

A Systematic Review of the Efficacy and Safety of Over-the-Counter Medications Used in Older People for the Treatment of Primary insomnia

2021 ◽  
Vol 36 (2) ◽  
pp. 83-91
Author(s):  
Sandrah-Ann M. Almond ◽  
Madelyne J. Warren ◽  
Kayce M. Shealy ◽  
Tiffaney B. Threatt ◽  
Eileen D. Ward
Keyword(s):  
Systematic Review ◽  
Adverse Effects ◽  
Older People ◽  
Positive Impact ◽  
Data Extraction ◽  
Sleep Time ◽  
Outpatient Setting ◽  
Primary Insomnia ◽  
Over The Counter ◽  
Safety Issues

OBJECTIVE: The purpose of this systematic review is to evaluate the available evidence for safety and efficacy of over-the-counter (OTC) sleep aids used for the treatment of insomnia in older people.<br/> DATA SOURCES: PubMed, EBSCO, and International Pharmaceutical Abstracts.<br/> STUDY SELECTION: Five studies were included that involved humans 65 years of age and older being evaluated on OTC sleep aids in the outpatient setting.<br/> DATA EXTRACTION: Data extraction from each study included primary and secondary efficacy endpoints, such as differences in the mean total sleep time, sleep latency, sleep efficiency, and number of awakenings, along with safety endpoints, such as psychomotor ability, cognitive ability, and adverse effect profiles. Both subjective and objective measures of changes in sleep and adverse effects were included.<br/> DATA SYNTHESIS: Diphenhydramine had a statistically significant increase in sedation and decrease in number of awakenings but was not shown to be any less or more safe than compared products. Despite lacking safety issues, valerian was found to have no effect on subjective or objective sleep outcomes. Overall, melatonin had the most evidence and was found to have a statistically significant positive impact on sleep measures without safety issues.<br/> CONCLUSION: Diphenhydramine and melatonin appear to be efficacious in improving some sleep measures while causing minimal adverse effects. However, there are very few studies that examine the use of over-the-counter sleep aids in those 65 years of age and older with primary insomnia. Additional studies are needed in this population.

scholarly journals A Systematic Review of the Efficacy and Safety of Over-the-Counter Medications Used in Older People for the Treatment of Primary Insomnia

2021 ◽  
Vol 36 (2) ◽  
pp. 83-92
Author(s):  
Sandrah-Ann M. Almond ◽  
Madelyne J. Warren ◽  
Kayce M. Shealy ◽  
Tiffaney B. Threatt ◽  
Eileen D. Ward
Keyword(s):  
Systematic Review ◽  
Adverse Effects ◽  
Older People ◽  
Positive Impact ◽  
Data Extraction ◽  
Sleep Time ◽  
Outpatient Setting ◽  
Primary Insomnia ◽  
Over The Counter ◽  
Safety Issues

Objective The purpose of this systematic review is to evaluate the available evidence for safety and efficacy of over-the-counter (OTC) sleep aids used for the treatment of insomnia in older people. Data Sources PubMed, EBSCO, and International Pharmaceutical Abstracts. Study Selection: Five studies were included that involved humans 65 years of age and older being evaluated on OTC sleep aids in the outpatient setting. Data Extraction Data extraction from each study included primary and secondary efficacy endpoints, such as differences in the mean total sleep time, sleep latency, sleep efficiency, and number of awakenings, along with safety endpoints, such as psychomotor ability, cognitive ability, and adverse effect profiles. Both subjective and objective measures of changes in sleep and adverse effects were included. Data Synthesis Diphenhydramine had a statistically significant increase in sedation and decrease in number of awakenings but was not shown to be any less or more safe than compared products. Despite lacking safety issues, valerian was found to have no effect on subjective or objective sleep outcomes. Overall, melatonin had the most evidence and was found to have a statistically significant positive impact on sleep measures without safety issues. Conclusion Diphenhydramine and melatonin appear to be efficacious in improving some sleep measures while causing minimal adverse effects. However, there are very few studies that examine the use of over-the-counter sleep aids in those 65 years of age and older with primary insomnia. Additional studies are needed in this population.

scholarly journals PRODUTOS CLAREADORES OVER THE COUNTER: UMA REVISÃO DE LITERATURA

2015 ◽  
Vol 6 (2) ◽  
Author(s):  
Adriele Caldas ◽  
Diane Vasconcelos ◽  
Geovana Sampaio ◽  
Juliana Campos ◽  
Lilibeth Aragão ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Tooth Whitening ◽  
Over The Counter ◽  
Tooth Sensitivity ◽  
Aesthetic Appeal ◽  
Advantages And Disadvantages ◽  
Convenience Stores ◽  
White Teeth

In order to the great aesthetic appeal for white teeth today, whitening has become very popular and affordable on the market. In the current days, there are many whitening products available in pharmacies, groceries and convenience stores. These products are called “over the counter” or OTC products. They are sold as cosmetics with non-prescription. The objective of this study is to review the literature articles surveyed in BVS, Scielo , Medline databases following the Descritores em Ciências da Saúde ( DeCS ) with emphasis on recent bleaching techniques introduced to the market as well as its indications, contraindications, advantages and disadvantages. OTC products do not have commercial regulation which hinders the supervision of tooth whitening by a dentist. These contain different concentrations of hydrogen peroxide or carbamide which can bring consequences such as tooth sensitivity and gum when used without indication and supervision.

Acetaminophen: Neonatal hepatotoxicity due to late pregnancy exposure

1987 ◽  
Vol 45 ◽  
pp. 718-719
Author(s):  
G.A. Miranda ◽  
M.A. Arroyo ◽  
C.A. Lucio ◽  
M. Mongeotti ◽  
S.S. Poolsawat
Keyword(s):  
Low Dose ◽  
Fetal Liver ◽  
Late Pregnancy ◽  
Toxic Chemicals ◽  
Control Group ◽  
High Dose ◽  
Over The Counter ◽  
Liver And Kidney ◽  
Neonatal Liver ◽  
Childbearing Women

Exposure to drugs and toxic chemicals, during late pregnancy, is a common occurrence in childbearing women. Some studies have reported that more than 90% of pregnant women use at least 1 prescription; of this, 60% used more than one. Another study indicated that 80% of the consumed drugs were not prescribed, and of this figure, 95% were “over-the-counter” drugs. Acetaminophen, the safest of all over-the-counter drugs, has been reported to induce fetal liver necrosis in man and animals and to have abortifacient and embryocidal action in mice. This study examines the degree to which acetaminophen affects the neonatal liver and kidney, when a fatty diet is simultaneously fed to the mother during late pregnancy.Timed Swiss Webster female mice were gavaged during late pregnancy (days 16-19) with fat suspended acetaminophen at a high dose, HD = 84.50 mg/kg, and a low dose, LD = 42.25 mg/kg; a control group received fat alone.

NSAIDs' Safety Issues May Spur Clinical Change

2005 ◽  
Vol 36 (9) ◽  
pp. 50-51
Author(s):  
BRUCE JANCIN
Keyword(s):  
Clinical Change ◽  
Safety Issues
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