EFFICACY AND SAFETY OF DEFERASIROX WHEN COMPARED TO D EFERIPRONE AS ORAL IRON CHELATING AGENT : A RANDOMIZED CONTROL TRIAL

When medical scientists and/or practitioners are asked to comment on an article that may have already created a controversy of both a scientific and ethical nature in the public press, the temptation is irresistible to abandon the language of scientific articles and to call a spade a spade. I bow to that irresistible temptation. A plague on all houses except those who reported and conducted the study in this issue of Pediatrics.1 When the study in question was designed and executed (1985 to 1988), an extremely difficult situation had been created by others. An elaborate, expensive, and potentially both effective and dangerous new technology had been allowed to proliferate without the gathering of reliable information about its relative efficacy and safety.

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Efficacy and Safety of Edifoligide, an E2F Transcription Factor Decoy, For Prevention of Vein Graft Failure Following Coronary Artery Bypass Graft Surgery, Prevent IV: A Randomized Control Trial

Journal of Vascular Surgery ◽

10.1016/j.jvs.2005.12.036 ◽

2006 ◽

Vol 43 (2) ◽

pp. 427

Keyword(s):

Randomized Control Trial ◽

Graft Failure ◽

Artery Bypass ◽

Bypass Graft ◽

Artery Bypass Graft ◽

Efficacy And Safety ◽

Transcription Factor Decoy ◽

E2f Transcription Factor ◽

Randomized Control ◽

Vein Graft Failure

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Efficacy and Safety of Microdebrider Assisted Adenoidectomy over Conventional Adenoidectomy

Bengal Journal of Otolaryngology and Head Neck Surgery ◽

10.47210/bjohns.2020.v28i1.173 ◽

2020 ◽

Vol 28 (1) ◽

pp. 59-66

Author(s):

Anil S Harugop ◽

Samanvaya Soni ◽

Tejaswini J S

Keyword(s):

Blood Loss ◽

Randomized Control Trial ◽

Operative Time ◽

Conventional Group ◽

Efficacy And Safety ◽

Intraoperative Blood Loss ◽

Average Amount ◽

Adenoid Tissue ◽

Randomized Control ◽

One Year

Introduction Adenoidectomy has conventionally been performed by curetting the adenoid tissue blindly with St. Clair Thompson curette leading to inadequate removal of tissue. Here the use of endoscopic guided adenoidectomy with microdebrider has been employed to compare the two methods. Materials and Methods It is a one-year randomized control trial conducted from January 2018 to December 2018. Patients were allocated into 2 groups i.e. conventional adenoidectomy and microdebrider adenoidectomy group. Pre and post-operative endoscopic grading of adenoid was compared and intraoperative blood loss and operative time were studied. Results Total 45 patients included 25 in conventional and 20 in microdebrider group. Following adenoidectomy operation the percentage of reduction of adenoid grading in microdebrider group was 63.79 % whereas 30.29% in conventional group, the average time taken by microdebrider assisted surgery was 16.45 mins as compared to 13.28 mins in conventional curettage. The average amount of blood loss in conventional group was 44.76 ml whereas in microdebrider group was 77.30 ml. Conclusion Microdebrider assisted adenoidectomy has proven to deliver completeness of clearance at the expense of slight increase in bleeding and the operative time.

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