ROLE OF THYROID FUNCTION TEST IN CASES WITH PROVISIONAL DIAGNOSIS OF DYSFUNCTIONAL UTERINE BLEEDING

Aims: To evaluate and detect the thyroid dysfunction in patients with abnormal uterine bleeding (AUB) from puberty to menopause.Methods: This is an observational descriptive study of 90 patients of abnormal uterine bleeding at Paropakar Maternity and Women’s Hospital, Kathmandu from 17th January 2016 to 16th January 2017. Besides thyroid function test Pap smear, endometrial biopsy and histo-pathological examination of uterus following hysterectomy was done in selected cases.Results: The incidence of AUB was 6.2 % with mean age of 37 years. The most common presenting complaint was menorrhagia (36.7%) followed by metrorrhagia (23.3%). Thyroid dysfunction accounted for 20% of AUB with major share occupied by subclinical hypothyroidism (11%) and least by hyperthyroidism (1%). The most common association of thyroid dysfunction with AUB was overt hypothyroidism (27.3%) with menorrhagia. Non-structural cases of AUB accounted for 30.4% of thyroid dysfunction.Conclusions: This study shows that thyroid dysfunction plays significant role for AUB so it is wise enough to perform TFT on routine basis in order to avoid unnecessary hormonal treatment with Estrogen, Progesterone or their combination and even the hysterectomies.

Download Full-text

Immunoradiometric assay of thyrotropin as a "first-line" thyroid-function test in the routine laboratory.

Clinical Chemistry ◽

10.1093/clinchem/32.4.691 ◽

1986 ◽

Vol 32 (4) ◽

pp. 691-693 ◽

Cited By ~ 19

Author(s):

M R Hopton ◽

J S Harrop

Keyword(s):

Thyroid Function ◽

Thyroid Function Test ◽

Primary Hypothyroidism ◽

Thyroid Function Tests ◽

Immunoradiometric Assay ◽

Routine Laboratory ◽

First Line ◽

Function Test ◽

Antithyroid Treatment

Abstract We compared the utility of a sensitive immunoradiometric assay for serum thyrotropin as a "first-line" thyroid-function test with a strategy based on first measuring total thyroxin in serum. The immunoradiometric assay appears to distinguish primary hypothyroidism and hyperthyroidism from euthyroidism in "new" patients. The role of this test in monitoring antithyroid treatment or thyroxin-replacement therapy is not yet established, there being particular difficulty in interpreting low thyrotropin concentrations in such patients. Nevertheless, because a normal thyrotropin concentration in most, if not all, situations signifies the euthyroid state, thyrotropin determination by immunoradiometric assay merits consideration as an initial test by laboratories performing thyroid-function tests.

Download Full-text

A study on thyroid dysfunction in acne vulgaris

International Journal of Research in Dermatology ◽

10.18203/issn.2455-4529.intjresdermatol20194660 ◽

2019 ◽

Vol 5 (4) ◽

pp. 736

Author(s):

Shreya Srinivasan ◽

Jayakar Thomas

Keyword(s):

Thyroid Function ◽

Acne Vulgaris ◽

Thyroid Function Test ◽

Thyroid Stimulating Hormone ◽

Thyroid Antibodies ◽

Male Population ◽

Free T4 ◽

Free T3 ◽

Function Test

Background: This study was done to evaluate the role of thyroid function i.e., free T3, free T4 and thyroid stimulating hormone (TSH) in relation to the occurrence of acne vulgaris.Methods: A total of 50 patients clinically diagnosed with acne vulgaris were subjected to a thyroid function test and results were evaluated.Results: While all the 50 patients had normal free T3 and free T4 levels, 9 (18%) of the 50 patients displayed an elevated TSH level. Gender distribution among the patients with elevated TSH learned more towards the male population with 6 patients while there were only 3 female patients with elevated TSH.Conclusions: There have been few studies regarding the role of thyroid function in acne vulgaris in relation to free T3, free T4 and TSH, though the presence of thyroid antibodies have been highlighted in quite a few studies. This study has shown the insignificance of thyroid function in acne vulgaris thus accentuating the negative.

Download Full-text