Cardiac Magnetic Resonance Assessment of Myocardial Steatosis

2017 ◽  
Author(s):  
Lisa Gillinder
Author(s):  
G.D. Clarke ◽  
J. Li ◽  
A.H. Kuo ◽  
A.J. Moody ◽  
P.W. Nathanielsz

Abstract Cardiovascular diseases (CVD) are important consequences of adverse perinatal conditions such as fetal hypoxia and maternal malnutrition. Cardiac magnetic resonance imaging (CMR) can produce a wealth of physiological information related to the development of the heart. This review outlines the current state of CMR technologies and describes the physiological biomarkers that can be measured. These phenotypes include impaired ventricular and atrial function, maladaptive ventricular remodeling, and the proliferation of myocardial steatosis and fibrosis. The discussion outlines the applications of CMR to understanding the developmental pathways leading to impaired cardiac function. The use of CMR, both in animal models of developmental programming and in human studies, is described. Specific examples are given in a baboon model of intrauterine growth restriction (IUGR). CMR offers great potential as a tool for understanding the sequence of dysfunctional adaptations of developmental origin that can affect the human cardiovascular system.


2018 ◽  
Author(s):  
Matilde Calanchini ◽  
Elizabeth Orchard ◽  
Saul Myerson ◽  
Fiona McMillan ◽  
Jason Bradley-Watson ◽  
...  

2007 ◽  
Vol 3 (2) ◽  
pp. 38
Author(s):  
Covadonga Fernández-Golfín ◽  
José Luis Zamorano ◽  
◽  

2011 ◽  
Vol 7 (3) ◽  
pp. 225
Author(s):  
Gianfranco Sinagra ◽  
Michele Moretti ◽  
Giancarlo Vitrella ◽  
Marco Merlo ◽  
Rossana Bussani ◽  
...  

In recent years, outstanding progress has been made in the diagnosis and treatment of cardiomyopathies. Genetics is emerging as a primary point in the diagnosis and management of these diseases. However, molecular genetic analyses are not yet included in routine clinical practice, mainly because of their elevated costs and execution time. A patient-based and patient-oriented clinical approach, coupled with new imaging techniques such as cardiac magnetic resonance, can be of great help in selecting patients for molecular genetic analysis and is crucial for a better characterisation of these diseases. This article will specifically address clinical, magnetic resonance and genetic aspects of the diagnosis and management of cardiomyopathies.


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