scholarly journals Structural Equation Modeling to Detect Predictors of CD4 Cell Count Change due to Long Term Antiretroviral Therapy Administered to HIV-Positive Adults at Felege Hiwot Teaching and Specialized Hospital, Bahir Dar, Ethiopia

2020 ◽  
Vol 2 (2) ◽  
pp. 15-27
Author(s):  
Awoke Seyoum Tegegne
Keyword(s):  
Structural Equation Modeling ◽  
Cell Count ◽  
Structural Equation ◽  
Equation Modeling ◽  
Cd4 Cell Count ◽  
Fit Index ◽  
Cd4 Cell ◽  
Count Change ◽  
Cd4 Cell Count Change ◽  
Hiv Aids

Background The relationship between predictors and the variable of interest was estimated using a structural equation model which is used to predict latent variables. The main advantage of the SEM is the ability to estimate the direct and indirect pathways of the effect of the primary independent variable on the outcome, given sufficient sample sizes. Despite not directly modeling the mediated pathways, GLMMs excluding mediating variables performed well with respect to power, bias and coverage probability in modeling the total effect of the primary independent variables on the outcome. In longitudinal studies, data are collected from subjects at several time points. The main purpose of longitudinal analysis is to detecting the trends or trajectories of the variables of interest. Methods A longitudinal study was conducted on 792 adults living with HIV/AIDS who commenced HAART. Structural equation modeling was used to construct a model to detecting predictors of CD4 cell count change. The procedure was illustrated by applying it to longitudinal health-related quality-of-life data on HIV/AIDS patients, collected from September 2008 to August 2012 monthly for the first six months and quarterly for remaining study period. Results The result of current investigation indicates that CD4 cell count change was highly influenced by certain socio-demographic and clinical variables. Out of all the participants, 141 (82%) have been considered 100% adherent to antiretroviral therapy. Structural equation modeling has confirmed the direct effect that personality (decision-making and tolerance of frustration) has on motives to behave, or act accordingly, which was in turn directly related to medication adherence behaviors. In addition, these behaviors have had a direct and significant effect on viral load, as well as an indirect effect on CD4 cell count. The final model demonstrates the congruence between theory and data (x2/df. = 1.480, goodness of fit index = 0.97, adjusted goodness of fit index = 0.94, comparative fit index = 0.98, root mean square error of approximation = 0.05), accounting for 55.7% of the variance. Conclusions The results of this study support our theoretical model as a conceptual framework for the prediction of medication adherence behaviors in persons living with HIV/AIDS. Implications for designing, implementing, and evaluating intervention programs based on the model are to be discussed.

scholarly journals Socio-Demographic and Clinical Predictor Variables on CD4 Cell Count Change among HIV Positive adults; a Structural Equations Modelling

2020 ◽  
Author(s):  
Awoke Seyoum ◽  
Principal Ndlovu Ndlovu ◽  
Temesgen Zewotire Zewotire
Keyword(s):  
Cell Count ◽  
Structural Equation ◽  
Structural Equations ◽  
Equation Modeling ◽  
Hiv Positive ◽  
Cd4 Cell Count ◽  
Hiv Positive Adults ◽  
Cd4 Cell ◽  
Count Change ◽  
Cd4 Cell Count Change

Abstract Background: The prevalence of HIV/AIDS among adult individuals has been increasing in Sub-Sahara African countries over the last decade. In Ethiopia , the prevalence of HIV among adults was 1%. Hence, 23, 000 people were newly infected with HIV and 11,000 people were died because of AIDS related illness in 2018. The purpose of this study was to identify the most significant socio-demographic, economic, individual and clinical determinants of CD4 cell count change in HIV positive adults who initiated HAART at Felege Hiwot Teaching and Specialized Hospital, North-West Ethiopia. Methods: A secondary and retrospective study design was conducted on 792 HIV positive adults. A structural equation modeling was employed to identify the socio-demographic and clinical covariates that have a statistically significant effect on the status of CD4 cell count change. Results: Literate patients, patients living with partner, patients living in urban area, patients disclosed the disease to family members, high income , ownership of cell, age and sex (male) were statistically significant variables. Conclusion: There was direct relation between socio-demographic variables with retention of HIV positive individuals in HAART program. There was also a direct and significant effect of clinical variables on adherence competence and adherence on CD4 cell change. Retention of patients in the HAART program had direct and significant effect on CD4 cell count change. This finding will be important for policy makers, health officials and for patients to easier access to healthcare service. Keywords: Socio-demographic, clinical factors, individual characteristics, Structural equation, CD4count change

scholarly journals Assessment of Casual Relations, Direct and Indirect Effects of Latent Covariates On CD4 Cell Count Change Among HIV Positive Adults

2021 ◽  
Author(s):  
Awoke Seyoum Tegegne
Keyword(s):  
Cell Count ◽  
Indirect Effect ◽  
Latent Variables ◽  
Hiv Positive ◽  
Health Staff ◽  
Cd4 Cell Count ◽  
Hiv Positive Adults ◽  
Cd4 Cell ◽  
Count Change ◽  
Cd4 Cell Count Change

Abstract Background: The use of structural equation modelling and latent variables remains unusual in epidemiology despite its potential usefulness and assessment of casual relations. Measuring direct and indirect effect of latent variables helps for proper intervention and for the ART program to be effective. The main objective of current investigation was to assess casual relations, direct and indirect effect of latent covariates on CD4 cell count change for HIV positive adults under HAART. Methods: Based on the repeated measures of CD4 cell count change data obtained in ART section at Felege Hiwot Teaching and Specialized hospital, AMOS software was employed parameter estimation. The data was conducted on 792 randomly selected HIV positive adults. The data was collected by the health staff for sake of delivering medication adherence. Results: CD4 cell count change was directly and indirectly affected by the latent variables. The powers of effects of observed variables with and without latent variables were a little bit different from each other. Hence, the power effect of observed variables with latent variables was lower as compared to without latent variables. The direct effect of latent variables on the response variable was a little bit greater than indirect effect. Conclusion: The power of effects of observed variables were stronger than their effects with latent variables. Hence, the latent variables had significant contributions for progress of CD4 cell count change. Health related education about the direct and indirect effect of latent variables should be given for patients under HAART.

scholarly journals MODEL PENGUKURAN TINGKAT KEPERCAYAAN PELANGGAN (ONLINE TRUST) TERHADAP SITUS E-COMMERCE (Studi Kasus pada Pelanggan E-Commerce di Provinsi Bali)

2018 ◽  
Vol 1 (3) ◽  
pp. 100
Author(s):  
I Made Endra Wiartika Putra ◽  
Gede Rasben Dantes ◽  
I Made Candiasa
Keyword(s):  
Structural Equation Modeling ◽  
Structural Equation ◽  
Goodness Of Fit ◽  
Equation Modeling ◽  
Snowball Sampling ◽  
Cronbach’S Alpha ◽  
Purposive Sampling ◽  
Online Trust ◽  
Cronbach's Alpha ◽  
Fit Index

Penelitian ini bertujuan untuk mengetahui model pengukuran tingkat kepercayaan pelanggan terhadap situs e-commerce. Langkah awal yang dilakukan yaitu identifikasi faktor-faktor yang mempengaruhi kepercayaan pelanggan melalui studi literatur dan studi empirik untuk menentukan model analisis terhadap kepuasan pelanggan. Faktor yang mempengaruhi kepercayaan pelanggan untuk bertransaksi secara online yaitu pengetahuan konsumen terhadap e-commerce, reputasi penjual, resiko dalam transaksi, kemudahan penggunaan e-commerce, jaminan sistem, sikap/perilaku terhadap sistem dan sistem keamanan. Populasi dalam penelitian ini adalah masyarakat Provinsi Bali menggunakan metode purposive sampling dan snowball sampling dengan kriteria responden pernah berkunjung dan melakukan transaksi di e-commerce yang ada di Indonesia lebih dari 3 kali. Instrumen penelitian berupa kuesioner dengan data interval berskala 5 Likert. Instrumen terlebih dahulu diuji validitas isi dengan metode Robert Gregory, validitas empiris menggunakan rumus product moment, reliabilitas instrument menggunakan Cronbach’s Alpha, dan menghasilkan 59 pernyataan yang dapat digunakan untuk pengambilan data. Jumlah responden yang digunakan dalam penelitian ini adalah sebanyak 126 responden. Teknik analisis data, pengujian hipotesis dan pengujian model menggunakan metode Structural Equation Modeling dengan bantuan aplikasi SPSS AMOS 21. Hasil penelitian ini melalui pengujian hipotesis menunjukkan bahwa pengetahuan tentang situs e-commerce dan perlindungan keamanan berpengaruh negatif dan tidak signifikan terhadap kepercayaan pelanggan. Resiko, kemudahan e-commerce, jaminan sistem dan sistem keamanan bukan menjadi sesuatu yang penting untuk dipertimbangkan dalam meningkatkan kepercayaan pelanggan karena pengaruhnya tidak signifikan. Reputasi yang dirasakan dan sikap merupakan hal yang perlu diperhatikan dan paling berpengaruh terhadap kepercayaan pelanggan pelanggan. Hasil penelitian ini kemudian diuji menggunakan goodness of fit index dan menghasilkan bahwa model penelitian tersebut dapat diterima dan dapat digunakan untuk meningkatkan keinginan pelanggan untuk bertransaksi online

Effects of CD4 cell count and antiretroviral therapy on mucocutaneous manifestations among HIV/AIDS patients in Yunnan, China

2019 ◽  
Vol 59 (3) ◽  
pp. 308-313 ◽  
Author(s):  
Yu‐Ye Li ◽  
Shi‐Han Yang ◽  
Rui‐Rui Wang ◽  
Jun‐Ting Tang ◽  
Hong‐Mei Wang ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Cell Count ◽  
Aids Patients ◽  
Cd4 Cell Count ◽  
Cd4 Cell ◽  
Hiv Aids

The Adult-Oriented Sport Coaching Survey: An Instrument Designed to Assess Coaching Behaviors Tailored to Adult Athletes

2020 ◽  
Vol 42 (5) ◽  
pp. 368-385
Author(s):  
Scott Rathwell ◽  
Bradley W. Young ◽  
Bettina Callary ◽  
Derrik Motz ◽  
Matt D. Hoffmann ◽  
...  
Keyword(s):  
Factor Analysis ◽  
Structural Equation Modeling ◽  
Root Mean Square ◽  
Structural Equation ◽  
Equation Modeling ◽  
Mean Square ◽  
Root Mean Square Residual ◽  
Confirmatory Factor ◽  
Masters Athletes ◽  
Fit Index

Adult sportspersons (Masters athletes, aged 35 years and older) have unique coaching preferences. No existing resources provide coaches with feedback on their craft with Masters athletes. Three studies evaluated an Adult-Oriented Coaching Survey. Study 1 vetted the face validity of 50 survey items with 12 Masters coaches. Results supported the validity of 48 items. In Study 2, 383 Masters coaches completed the survey of 50 items. Confirmatory factor analysis and exploratory structural equation modeling indicated issues with model fit. Post hoc modifications improved fit, resulting in a 22-item, five-factor model. In Study 3, 467 Masters athletes responded to these 22 items reflecting perceptions of their coaches. Confirmatory factor analysis (comparative fit index = .951, standardized root mean square residual = .036, and root mean square error of approximation = .049) and exploratory structural equation modeling (comparative fit index = .977, standardized root mean square residual = .019, and root mean square error of approximation = .041) confirmed the model. The resultant Adult-Oriented Sport Coaching Survey provides a reliable and factorially valid instrument for measuring adult-oriented coaching practices.

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